Anne Sofie Andreasen
A5041325858- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Family and Patient Care in Intensive Care Units
- Gut microbiota and health
- Clinical Reasoning and Diagnostic Skills
- SARS-CoV-2 and COVID-19 Research
- Clinical Nutrition and Gastroenterology
- Immune Response and Inflammation
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Diabetes and associated disorders
- Palliative Care and End-of-Life Issues
- Enhanced Recovery After Surgery
- Neutropenia and Cancer Infections
- TGF-β signaling in diseases
- COVID-19 and healthcare impacts
- Kruppel-like factors research
- Delphi Technique in Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Surgical site infection prevention
Herlev Hospital
2019-2025
Copenhagen University Hospital
2009-2025
University of Copenhagen
2008-2024
Gentofte Hospital
2001-2024
Slagelse Hospital
2021
Zealand University Hospital
2021
Frederiksberg Hospital
2021
Aalborg University Hospital
2021
Aarhus University Hospital
2021
Hvidovre Hospital
2021
Background Recent evidence suggests that there is a link between metabolic diseases and bacterial populations in the gut. The aim of this study was to assess differences composition intestinal microbiota humans with type 2 diabetes non-diabetic persons as control. Methods Findings included 36 male adults broad range age body-mass indices (BMIs), among which 18 subjects were diagnosed 2. fecal investigated by real-time quantitative PCR (qPCR) subgroup (N = 20) tag-encoded amplicon...
According to animal studies, intake of probiotic bacteria may improve glucose homeostasis. We hypothesised that insulin sensitivity by attenuating systemic inflammation. Therefore, the effects oral supplementation with bacterium Lactobacillus acidophilus NCFM on and inflammatory response were investigated in subjects normal or impaired sensitivity. In a double-blinded, randomised fashion, forty-five males type 2 diabetes, tolerance enrolled allocated 4-week treatment course either L....
Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated supplemental oxygen, but benefits and harms of different oxygenation targets unclear. We hypothesized that using a lower target for partial pressure arterial oxygen (Pao2) would result mortality than higher target.
We compared dexamethasone 12 versus 6 mg daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia the international, randomised, blinded COVID STEROID 2 trial. In primary, conventional analyses, predefined statistical significance thresholds were not reached. conducted a pre-planned Bayesian analysis facilitate probabilistic interpretation. analysed outcome data within 90 intention-to-treat population (data available 967 982 patients) using models...
Haloperidol is frequently used to treat delirium in patients the intensive care unit (ICU), but evidence of its effect limited.
Importance Supplemental oxygen is ubiquitously used in patients with COVID-19 and severe hypoxemia, but a lower dose may be beneficial. Objective To assess the effects of targeting Pa o 2 60 mm Hg vs 90 hypoxemia intensive care unit (ICU). Design, Setting, Participants Multicenter randomized clinical trial including 726 adults receiving at least 10 L/min or mechanical ventilation 11 ICUs Europe from August 2020 to March 2023. The was prematurely stopped prior outcome assessment due slow...
We assessed long-term outcomes in acutely admitted adult patients with delirium treated intensive care unit (ICU) haloperidol versus placebo.
Systemic inflammation is often associated with impaired glucose metabolism. We therefore studied the activation of inflammatory pathway intermediates that interfere uptake during systemic by applying a standardised stimulus in vivo. After ethical approval, informed consent and thorough physical examination, 10 patients type 2 diabetes participants normal tolerance (NGT) were given an intravenous bolus E. coli lipopolysaccharide (LPS) 0.3 ng/kg. Skeletal muscle biopsies plasma obtained at...
Background In the early phase of pandemic, some guidelines recommended use corticosteroids for critically ill patients with COVID‐19, whereas others against despite lack firm evidence either benefit or harm. COVID STEROID trial, we aimed to assess effects low‐dose hydrocortisone on patient‐centred outcomes in adults COVID‐19 and severe hypoxia. Methods this multicentre, parallel‐group, placebo‐controlled, blinded, centrally randomised, stratified clinical randomly assigned confirmed hypoxia...
Abstract Background Plasma follistatin is elevated in patients with low‐grade inflammation and insulin resistance as observed polycystic ovary syndrome. In the present study, we evaluated plasma type 2 diabetes characterised by assessed acute effects of hyperglycemia, hyperinsulinemia LPS on follistatin. Methods Baseline inflammatory biomarkers were measured a cross‐sectional study that involved 95 103 matched controls. To determine effect hyperglycemia follistatin, hyperglycemic...
Abstract Background Venous thromboembolism (VTE) is a frequent complication in critically ill patients, who often have multiple risk factors. Pharmacological thromboprophylaxis widely applied to lower this risk, but guidelines lack dosing recommendations. Objective This survey aims assess current preferences and willingness participate future randomized clinical trials (RCTs) on topic. Method We conducted an international online between February May 2023 among intensive care unit (ICU)...
Abstract Introduction Severe acute respiratory syndrome coronavirus‐2 has caused a pandemic of coronavirus disease (COVID‐19) with many patients developing hypoxic failure. Corticosteroids reduce the time on mechanical ventilation, length stay in intensive care unit and potentially also mortality similar patient populations. However, corticosteroids have undesirable effects, including longer to viral clearance. Clinical equipoise use for COVID‐19 exists. Methods The COVID STEROID trial is an...
Coronavirus disease 2019 (COVID-19) may be associated with cardiac arrhythmias in hospitalized patients, but data from the ICU setting are limited. We aimed to describe epidemiology of patients COVID-19.We conducted a multicenter, retrospective cohort study including all an airway sample positive for severe acute respiratory syndrome corona-virus 2 March 1st June Capital Region Denmark (1.8 million inhabitants). registered ICU, potential risk factors, interventions used and outcomes.From...
To explore perspectives and wishes for patient family centred care among adult patients family-members with recent experience of admission to an intensive unit.An explorative descriptive study using inductive thematic analysis. Semi-structured interviews adults (≥18 years) who had experienced ≥48 hours unit as a or family-member within the previous three months. Interview data were analysed used six phases analysis, described by Braun Clarke. Clarke.Participants recruited from general (mixed...
Glutamine supplementation has beneficial effects on morbidity and mortality in critically ill patients, possibly part through an attenuation of the proinflammatory cytokine response a stimulation heat shock protein (HSP)70. We infused either alanine-glutamine or saline during endotoxin challenge measured plasma cytokines HSP70 expression.This crossover study, conducted eight healthy young men, was double-blind, randomized placebo-controlled. It performed 2 trial days, separated by 4-week...
1. Drope J, Schluger N, Cahn Z, Hamill S, Islami F, Liber A, Nargis Stoklosa M. The Tobacco Atlas. Atlanta, GA: American Cancer Society, Vital Strategies; 2018. https://tobaccoatlas.org/wp-co.... Accessed January 22, 2021. Google Scholar
To establish consensus between intensive care unit (ICU) experts on concrete patient- and family-centered statements for adult patients relatives in the ICU.
Coronavirus disease 2019 (COVID-19) can lead to severe hypoxic respiratory failure and death. Corticosteroids decrease mortality in severely or critically ill patients with COVID-19. However, the optimal dose remains unresolved. The ongoing randomised COVID STEROID 2 trial investigates effects of higher vs lower doses dexamethasone (12 6 mg intravenously daily for up 10 days) 1,000 adult COVID-19 hypoxia.
Background . Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity. In humans, plasma fstl3 reduced gestational diabetes. vitro , TNF- α induces secretion, which suggests a link to inflammation. Objective To elucidate the association between obesity, insulin resistance, low-grade inflammation in humans. Study Design Plasma levels were determined cross-sectional study including three groups: patients type 2 diabetes, impaired glucose tolerance, healthy...