A5028647748- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Renal function and acid-base balance
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Long-Term Effects of COVID-19
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Non-Invasive Vital Sign Monitoring
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Climate Change and Health Impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- Antibiotic Use and Resistance
- Electrolyte and hormonal disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ultrasound in Clinical Applications
- Blood Pressure and Hypertension Studies
- Thermal Regulation in Medicine
- SARS-CoV-2 and COVID-19 Research
- Venous Thromboembolism Diagnosis and Management
Case Western Reserve University
2020-2025
University of Banja Luka
2025
Cleveland Clinic Lerner College of Medicine
2020-2025
Cleveland Clinic
2018-2025
Abu Dhabi Health Services
2025
Physiopathologie et Stratégies d'Imagerie du Remodelage cardiovasculaire
2024
Smile Train
2024
Technology Innovation Institute
2020-2023
Université de Caen Normandie
2020-2023
Centre Hospitalier d'Arras
2016-2023
To test whether the polymyxin B hemoperfusion (PMX HP) fiber column reduces mortality and organ failure in peritonitis-induced septic shock (SS) from abdominal infections. Prospective, multicenter, randomized controlled trial 18 French intensive care units October 2010 to March 2013, enrolling 243 patients with SS within 12 h after emergency surgery for peritonitis related perforation. The PMX HP group received conventional therapy plus two sessions of HP. Primary outcome was on day 28;...
Importance Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective To assess the impact on neurological outcome of 2 different thresholds guide red blood cell Design, Setting, and Participants Multicenter, phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial conducted 72 intensive care units across 22 countries. Eligible had...
Negative pressure pulmonary edema (NPPE) is a form of noncardiogenic (PE) that results from the generation high negative intrathoracic (NIP) needed to overcome upper airway obstruction (UAO). NPPE potentially life-threatening complication develops rapidly after UAO in otherwise healthy young persons who are capable producing large markedly NIPs. The incidence NPPE, patients developing acute UAO, has been estimated be up 12 % [1]. true incidence, however, not known and may higher than...
BACKGROUND Central venous-to-arterial carbon dioxide partial pressure difference (ΔPCO2) can be used as a marker for the efficacy of venous blood in removing total CO2 produced by tissues. To date, this role ΔPCO2 has been assessed only patients after resuscitation from septic shock with already normalised central oxygen saturation (ScvO2 ≥70%). There are no reports on behaviour and its relationship to cardiac index (CI) clinical outcome before normal ScvO2 achieved. OBJECTIVES investigate...
To evaluate the ability of central venous-to-arterial CO2 content and tension differences to arteriovenous oxygen difference ratios (∆ContCO2/∆ContO2 ∆PCO2/∆ContO2, respectively), blood lactate concentration, venous saturation (ScvO2) detect presence global anaerobic metabolism through increase in consumption (VO2) after an acute supply (DO2) induced by volume expansion (VO2/DO2 dependence).We prospectively studied 98 critically ill mechanically ventilated patients whom a fluid challenge was...
To investigate patients' characteristics, management, and outcomes in the critically ill population admitted to ICU for severe acute respiratory syndrome coronavirus disease 2019 pneumonia causing an distress syndrome.Retrospective case-control study.A 34-bed of a tertiary hospital.The first 44 patients were compared with historical control group 39 consecutive just before crisis.None.Obesity was most frequent comorbidity exhibited by (n = 32, 73% vs n 11, 28% controls; p < 0.001). Despite...
Objective: To evaluate the extent to which sitting position and applied positive end-expiratory pressure improve respiratory mechanics of severely obese patients under mechanical ventilation. Design: Prospective cohort study. Settings: A 15-bed ICU a tertiary hospital. Participants: Fifteen consecutive critically ill with body mass index (the weight in kilograms divided by square height meters) above 35 were compared 15 controls less than 30. Interventions: Respiratory was first assessed...
Purpose Acute respiratory failure (ARF) is a common life-threatening complication in morbidly obese patients with obesity hypoventilation syndrome (OHS). We aimed to identify the determinants of noninvasive ventilation (NIV) success or for this indication. Methods prospectively included 76 consecutive BMI>40 kg/m2 diagnosed OHS and treated by NIV ARF 15-bed ICU tertiary hospital. Results failed reverse only 13 patients. Factors associated pneumonia (n = 12/13, 92% vs n 9/63, 14%; p<0.0001),...
Abstract Background There is conflicting data regarding the use of hydroxychloroquine (HCQ) in COVID-19 hospitalized patients Objective To assess efficacy HCQ increasing SARS-CoV-2 viral clearance Design Retrospective observational study Setting Cleveland Clinic Abu Dhabi Participants Hospitalized adult with confirmed infection Intervention None Measurements The primary outcome was time from a positive nasopharyngeal swab to turn negative. A negative conversion defined as case followed by...
To evaluate the impact of switching to total face mask in cases where mask-delivered noninvasive mechanical ventilation has already failed do-not-intubate patients acute respiratory failure.Prospective observational study an ICU and a stepdown unit over 12-month period.Switching mask, which covers entire face, when using facial (oronasal mask) reverse failure.Seventy-four with order treated by for failure.Failure was associated three-fold increase in-hospital mortality (36% vs. 10.5%; p =...
Thiamine was the first B vitamin to be identified and is also referred as 1 . It a water-soluble that an indispensable constituent of cellular metabolism (1). A lack this can, therefore, potentially life-threatening (2).
Background: Critically ill patients with COVID-19 are prone to develop severe acute kidney injury (AKI), defined as KDIGO (Kidney Disease Improving Global Outcomes) stages 2 or 3. However, data limited in these patients. We aimed report the incidence, risk factors, and prognostic impact of AKI critically admitted intensive care unit (ICU) for respiratory failure. Methods: A retrospective monocenter study including adult laboratory-confirmed syndrome coronavirus-2 (SARS-CoV-2) infection ICU...
The objective of this study was to examine the repeatability blood gas (BG) parameters and their derived variables such as central venous-to-arterial carbon dioxide tension difference (▵PCO2) ratio ▵PCO2 over arteriovenous oxygen content (▵PCO2/C(a-cv)O2) determine smallest detectable changes in individual patients. A total 192 patients with arterial venous catheters were included prospectively. Two subsequent samples collected immediately one after other analyzed using same point-of-care BG...
Abstract There are conflicting data regarding the use of hydroxychloroquine (HCQ) in COVID-19 hospitalized patients. The objective this study was to assess efficacy HCQ increasing SARS-CoV-2 viral clearance. Hospitalized adult patients with confirmed infection were retrospectively included study. primary outcome time from a positive nasopharyngeal swab turn negative. A negative conversion defined as case followed by 2 results using RT-PCR assay samples obtained 24 hours apart. Multiple...
Severe coronavirus disease 2019 pneumonia can lead to acute respiratory distress syndrome. Recently, several publications reported on 2019-associated pulmonary aspergillosis. However, risk factors remain unclear. We retrospectively collected all the cases of syndrome patients ( n = 46) admitted our 34-bed ICU between March 24, 2020, and May 25, identified six that met diagnosis invasive aspergillosis according previously established definitions. This population exhibited higher severity...
The reported incidence rate of venous and arterial thrombotic events in critically ill patients with COVID-19 infections is high, ranging from 20% to 60%. We adopted a patient-tailored thromboprophylaxis protocol based on clinical laboratory presentations for these our institution. hypothesised that who received high-intensity treatment would experience fewer events. aims study were explore the this population; assess independent factors associated evaluate haemorrhagic A retrospective...
Background: Patients undergoing prolonged mechanical ventilation commonly require tracheotomy. The main aim of this study was to evaluate the outcomes tracheotomy for patients with acute respiratory distress syndrome (ARDS) associated COVID-19 in low-resource settings. Methods: A retrospective, single-center, observational cohort performed on ARDS COVID-19. who underwent intubation alone were compared those received both and subsequent analysis included patient demographics, comorbidities,...