Luigi Zattera

ORCID: 0000-0001-8967-8472
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About
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Research Areas
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Respiratory Support and Mechanisms
  • Intensive Care Unit Cognitive Disorders
  • Intracranial Aneurysms: Treatment and Complications
  • Neurosurgical Procedures and Complications
  • Airway Management and Intubation Techniques
  • COVID-19 Clinical Research Studies
  • Long-Term Effects of COVID-19
  • Cerebrospinal fluid and hydrocephalus
  • Thermal Regulation in Medicine
  • Dialysis and Renal Disease Management
  • Cardiac Arrest and Resuscitation
  • Adrenal Hormones and Disorders
  • Forensic Toxicology and Drug Analysis
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Sepsis Diagnosis and Treatment
  • Blood transfusion and management
  • Gut microbiota and health
  • Tracheal and airway disorders
  • Cannabis and Cannabinoid Research
  • Poisoning and overdose treatments
  • Neuroblastoma Research and Treatments
  • Alcohol Consumption and Health Effects
  • Cerebrovascular and Carotid Artery Diseases

Hospital Clínic de Barcelona
2020-2025

Universitat de Barcelona
2023-2025

Smile Train
2024

Universitat Pompeu Fabra
2022

Erasmus Hospital
2022

Hospital Clínico Universitario de Valencia
2020

Hospital Universitari i Politècnic La Fe
2020

Hospital Universitario de La Princesa
2020

Complejo Hospitalario de Pontevedra
2020

Hospital Del Mar
2018-2020

Fabio Silvio Taccone Carla Rynkowski Bittencourt Kirsten Møller Piet Lormans Manuel Quintana‐Díaz and 95 more Anselmo Caricato Marco Antonio Cardoso Ferreira Rafael Badenes Pedro Kurtz Christian Baastrup Søndergaard Kirsten Colpaert Letícia Petterson Hervé Quintard Raphaël Cinotti Elisa Gouvêa Bogossian Cássia Righy Serena Silva Erik Roman‐Pognuz Catherine Vandewaeter Daniel Lemke Olivier Huet Ata Mahmoodpoor Aaron Blandino Ortíz Mathieu van der Jagt Russell Chabanne Walter Videtta Pierre Bouzat Jean‐Louis Vincent Claudia I. Diaz Andrés Saravia Ahmas Bayrlee Laura Nedolast Hussam Elkambergy Haamid Siddique Jihad Mallat Nahla AlJaberi Samer Shoshan A Mándi Bruno De Oliveira Malligere Prasanna Rehan Haque Dnyaneshwar Munde Sara Chaffee Fatma Alawadhi Jamil Dibu Eija Junttila Teemu M. Luoto Simona Šteblaj Jacques Créteur D. Durand Caroline Abbenhuijs Nancy Itesa Matumikina Filippo Annoni Leda Nobile Miguel Ulloa Bersatti Igor Yovenko Alexander Tsarev Jasperina Dubois Evy Voets Luc Janssen Luigi Zattera Leire Pedrosa Berta López Ainhoa Serrano Nekane Romero-García Xavier Wittebole Antonio Maria Dell’Anna Camilla Gelormini Eleonora Stival Pilar Marcos-Neira Regina Roig Pineda Lara Bielsa Berrocal Maite Misis Stepani Bendel Jorge Mejía-Mantilla Ángela Marulanda Wojciech Dąbrowski Rune Damgaard Nielsen Markus Harboe Olsen Helene Ravnholt Jensen Ida Møller Larsen Roberta T. Tallarico Umberto Lucangelo Maria Isabel Gonzales Perez Carole Ichai Karim Asenhoune Karim Lakhal Charlotte Fernandez-Canal Samuel Gay Marie Lebouc David Bougon Étienne Escudier Michel Sirodot Albrice Levrat Alix Courouau Jacques Duranteau Aurore Rodrigues Naima Makouche Gilles Francony Olivier Vincent

Importance Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective To assess the impact on neurological outcome of 2 different thresholds guide red blood cell Design, Setting, and Participants Multicenter, phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial conducted 72 intensive care units across 22 countries. Eligible had...

10.1001/jama.2024.20424 article EN JAMA 2024-10-09
Chahnez Taleb Elisa Gouvêa Bogossian Carla Bittencourt Rynkowski Kirsten Møller Piet Lormans and 95 more Manuel Quintana‐Díaz Anselmo Caricato Luigi Zattera Pedro Kurtz Geert Meyfroidt Hervé Quintard Celeste Dias Angelo Giacomucci Charlotte Castelain Russell Chabanne Pilar Marcos-Neira Stepani Bendel Ahmed Subhy Alsheikhly Mohamed Elbahnasawy Samuel Gay Maximilian D’Onofrio К. А. Попугаев Νικόλαος Μάρκου Pierre Bouzat Jean‐Louis Vincent Fabio Silvio Taccone Marco Antonio Cardoso Ferreira Rafael Badenes Christian Baastrup Søndergaard Kirsten Colpaert Letícia Petterson Claudia I. Diaz Andrés Saravia Ahmad Bayrlee Laura Nedolast Hussam Elkambergy Haamid Siddique Jihad Mallat Nahla AlJaberi Samer Shoshan A Mándi Bruno De Oliveira Malligere Prasanna Rehan Haque Dnyaneshwar Munde Sara Chaffee Fatma Alawadhi Jamil Dibu Eija Junttila Teemu M. Luoto Simona Šteblaj Jacques Créteur D. Durand Caroline Abbenhuijs Nancy Itesa Matumikina Filippo Annoni Leda Nobile Miguel Ulloa Bersatti Igor Yovenko Alexander Tsarev Jasperina Dubois Evy Voets Luc Janssen Luigi Zattera Leire Pedrosa Berta López Ainhoa Serrano Nekane Romero-García Xavier Wittebole Antonio Maria Dell’Anna Camilla Gelormini Eleonora Stival Pilar Marcos-Neira Regina Roig Pineda Lara Bielsa Berrocal Maite Misis Jorge Mejía-Mantilla Ángela Marulanda Wojciech Dąbrowski Rune Damgaard Nielsen Markus Harboe Olsen Helene Ravnholt Jensen Ida Møller Larsen Roberta T. Tallarico Umberto Lucangelo Maria Isabel Gonzalez Perez Carole Ichai Karim Asenhoune Karim Lakhal Charlotte Fernandez-Canal Samuel Gay Marie Lebouc David Bougon Étienne Escudier Michel Sirodot Albrice Levrat Alix Courouau Jacques Duranteau Aurore Rodrigues Naima Makouche

The optimal hemoglobin (Hb) threshold to trigger red blood cell transfusions (RBCT) in subarachnoid hemorrhage (SAH) patients is unclear. This study evaluated the impact of liberal versus restrictive transfusion strategies on neurological outcome with SAH. a pre-planned secondary analysis "TRansfusion Strategies Acute brain INjured Patients" (TRAIN) study. We included all SAH from original that were randomized receive RBCT when Hb levels dropped below 9 g/dL (liberal group) or 7 (restrictive...

10.1186/s13054-025-05270-5 article EN cc-by-nc-nd Critical Care 2025-02-07

Aneurysmal subarachnoid hemorrhage (aSAH) is a rare cause of stroke that poses significant morbidity and mortality, as it affects patients around the age 50 years. While advances in early aneurysm intervention have reduced mortality rates, many still experience poor outcomes due to brain injury (EBI) delayed cerebral ischemia (DCI). This study aims explore characteristics with neurological among status at admission, using comprehensive clinical neuroimaging data. We analyzed 377 aSAH (WFNS...

10.3389/fneur.2025.1536643 article EN cc-by Frontiers in Neurology 2025-04-02

There is an overlap between the respiratory, blood and gut microbiomes in patients with acute respiratory distress syndrome. Specific taxa lungs are associated inflammatory response. https://bit.ly/3TdkHd7.

10.1183/23120541.00667-2024 article EN cc-by-nc ERJ Open Research 2024-09-12

Abstract Intrahospital transfer (IHT), a routine in the management of neurocritical patients requiring imaging or interventions, might affect brain metabolism. Studies about IHT effects using microdialysis (MD) have produced conflicting results. In these studies, only most damaged hemisphere was monitored, and those may not reflect impact on overall metabolism, nor do they address differences between hemispheres. Herein we aimed to quantify effect metabolism by monitoring both hemispheres...

10.1038/s41598-024-57217-5 article EN cc-by Scientific Reports 2024-03-28

Abstract Hyperglycemia during early brain injury (EBI) period after spontaneous subarachnoid hemorrhage (SAH) is associated with poor outcome, but the underlying physiopathology unknown. This study assessed if hyperglycemia EBI markers of neuroaxonal and whether these biomarkers partially account for association between clinical outcome. Ninety-two SAH patients admitted within 24 h bleeding onset were prospectively included. Glucose levels measured at arrival every 6 72 h. Serum...

10.1007/s12035-024-04347-6 article EN cc-by Molecular Neurobiology 2024-07-12

Stroke Units (SU) have been suggested as an alternative to Intensive Care units (ICU) for initial admission of low-grade non-aneurysmal spontaneous subarachnoid haemorrhage (naSAH). We hypothesised that the incidence in-hospital complications and long-term clinical outcomes in naSAH patients would be comparable both settings, a cost-minimisation analysis favour use SU.

10.1177/23969873231202361 article EN European Stroke Journal 2023-09-25

High levels of procalcitonin (PCT) have been associated with a higher risk mortality in COVID-19 patients. We explored the prognostic role early PCT assessment critically ill patients and whether predictive performance would be influenced by immunosuppression.Retrospective multicentric analysis prospective collected data consecutively admitted to 36 intensive care units (ICUs) Spain Andorra from March June 2020. Adult (>18 years) confirmed available values (<72 hours ICU admission) were...

10.23736/s0375-9393.22.15942-0 article EN Minerva Anestesiologica 2022-01-24

Abstract Intrahospital transfer (IHT), a routine in the management of neurocritical patients requiring imaging or interventions, might affect brain metabolism. Studies about IHT effects using microdialysis (MD) have produced conflicting results. In these studies, only most damaged hemisphere was monitored, and those may not reflect impact on overall metabolism, nor do they address differences between hemispheres. Herein we aimed to quantify effect metabolism by monitoring both hemispheres...

10.21203/rs.3.rs-3180261/v1 preprint EN cc-by Research Square (Research Square) 2023-08-02
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