A5037597807- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Atrial Fibrillation Management and Outcomes
- Respiratory Support and Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- Neurological and metabolic disorders
- Climate Change and Health Impacts
- Nosocomial Infections in ICU
- Blood transfusion and management
- S100 Proteins and Annexins
- Ophthalmology and Eye Disorders
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- Retinal and Optic Conditions
Smile Train
2024
Cleveland Clinic
2015-2022
The Neurological Institute
2015-2021
Johns Hopkins Medicine
2021
Johns Hopkins University
2021
University of Arkansas for Medical Sciences
2013-2015
Importance Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective To assess the impact on neurological outcome of 2 different thresholds guide red blood cell Design, Setting, and Participants Multicenter, phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial conducted 72 intensive care units across 22 countries. Eligible had...
Abstract Background Alternative noninvasive methods capable of excluding intracranial hypertension through use transcranial Doppler (ICP tcd ) in situations where invasive cannot be used or are not available would useful during the management acutely brain-injured patients. The objective this study was to determine whether ICP can considered a reliable screening test compared reference standard method, monitoring i ), presence hypertension. Methods This prospective, international,...
IMPORTANCETreatments for symptomatic intracerebral hemorrhage (sICH) are based on expert opinion, with limited data available efficacy.OBJECTIVE To better understand the natural history of thrombolysis-related sICH, a focus efficacy various treatments used.
<h3>SUMMARY:</h3> The mechanisms and phenotype of ischemic stroke associated with coronavirus disease 2019 (COVID-19) remain uncertain. A retrospective study was conducted in patients COVID-19 presenting from March 1 to May 25, 2020, cases large-vessel occlusion were identified. To provide baseline institutional data within outside the pandemic, all consecutive TIA admissions (COVID non-COVID) hospital during a 10-week period 10, collected compared same time 2019. Among 20 acute stroke, 15...
Background: Critically ill patients with COVID-19 are prone to develop severe acute kidney injury (AKI), defined as KDIGO (Kidney Disease Improving Global Outcomes) stages 2 or 3. However, data limited in these patients. We aimed report the incidence, risk factors, and prognostic impact of AKI critically admitted intensive care unit (ICU) for respiratory failure. Methods: A retrospective monocenter study including adult laboratory-confirmed syndrome coronavirus-2 (SARS-CoV-2) infection ICU...
The optimal hemoglobin (Hb) threshold to trigger red blood cell transfusions (RBCT) in subarachnoid hemorrhage (SAH) patients is unclear. This study evaluated the impact of liberal versus restrictive transfusion strategies on neurological outcome with SAH. a pre-planned secondary analysis "TRansfusion Strategies Acute brain INjured Patients" (TRAIN) study. We included all SAH from original that were randomized receive RBCT when Hb levels dropped below 9 g/dL (liberal group) or 7 (restrictive...
Hematoma growth is an independent determinant of outcome in patients with intracerebral hemorrhage (ICH). Predictors hematoma expansion are poorly defined. Our aim to determine predictors ICH.We reviewed our prospective database ICH between January 2009 and June 2012. Patients were divided into two groups based on the presence or absence expansion. volume was calculated by thin volumetric cuts using special software. Expansion defined as 33% increase over 24 hours. We compared risk factors,...
Nosocomial infections are frequent complications in patients with intracerebral hemorrhage.To determine the prevalence, risk factors, and outcomes of nosocomial hemorrhage.Prospectively collected data on spontaneous hemorrhage between January 2009 June 2012 were retrospectively reviewed. Patients who had infection during hospital stay compared did not. Poor outcome was defined as death or discharge to a long-term nursing facility.At least 1 developed 26% 202 hemorrhage. The most common...
There are limited data regarding the efficacy of methylprednisolone in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) requiring invasive mechanical ventilation. We aimed determine whether is associated increases number ventilator-free days (VFDs) among these patients.
(1) Background: There are limited data regarding the efficacy of convalescent plasma (CP) in critically ill patients admitted to intensive care unit (ICU) due coronavirus disease 2019 (COVID-19). We aimed determine whether CP is associated with better clinical outcome among these patients. (2) Methods: A retrospective single-center study including adult laboratory-confirmed SARS-CoV-2 infection ICU for acute respiratory failure. The primary was time improvement, within 28 days, defined as...
Objectives: There are limited data regarding the efficacy of methylprednisolone in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) requiring invasive mechanical ventilation. We aimed determine whether increases number ventilator-free days (VFDs) among these patients. Design: Retrospective single-center study Setting: Intensive care unit Patients: All ARDS confirmed SARS-CoV-2 infection and ventilation between 1 March 29 May 2020 were...
Objective: To determine the impact of seasonal variation on incidence Intracerebral hemorrhage (ICH) and its mortality. Background: Exposure to cold during winter has been associated with elevated blood pressure these values correlate external temperature. There was increased ICH winter. Hypertension is well known established risk factor for development ICH. Seasonal extensively studied in patients ischemic stroke aneurysmal subarachnoid but there limited data outcome spontaneous...
Background: The most feared complication from thrombolysis is symptomatic intracerebral hemorrhage (sICH). Current treatments for sICH are based on limited data. We aim to the efficacy of utilized. Methods: conducted a collaborative study 5 academic stroke centers (Columbia University, Massachusetts General Hospital, University Arkansas, Washington and UCLA) acute post-thrombolysis treatment. definition was Safe Implementation Thrombolysis in Stroke criteria. primary outcome in-hospital...
Background: Symptomatic intracerebral hemorrhage (sICH) is the most feared complication of thrombolytic therapy in acute ischemic stroke. There limited data on efficacy treatments to prevent hematoma expansion (HE). We hypothesized that treatment for sICH would reduce HE. Methods: This study was a collaboration from 5 stroke centers (Columbia University, Massachusetts General Hospital, University Arkansas, Washington and UCLA). Outcome HE, defined as 33% increase volume first 24 hours....
OBJECTIVE: To compare risk factors, comorbidities, complications, laboratory findings, medications and outcomes in patients with cocaine-related non-cocaine-related Intracerebral hemorrhage (ICH). BACKGROUND: Cocaine use is well known to cause ICH, most commonly secondary acute hypertension. There limited data on the clinical radiological characteristics outcome of cocaine related ICH. DESIGN/METHODS: Data was retrieved from our prospective database spontaneous ICH between January 2009 June...
OBJECTIVE: To study the impact of admission hyperglycemia on mortality, clinical and radiological parameters, medical complications in ICH.
OBJECTIVE: Our aim is to investigate a causal relationship between rise in serum cardiac-specific troponin and poor outcome patients with intracranial hemorrhage.