Νικόλαος Μάρκου

ORCID: 0000-0003-3969-839X
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About
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Research Areas
  • COVID-19 Clinical Research Studies
  • Oral microbiology and periodontitis research
  • Respiratory Support and Mechanisms
  • Long-Term Effects of COVID-19
  • Periodontal Regeneration and Treatments
  • Antibiotics Pharmacokinetics and Efficacy
  • Laser Applications in Dentistry and Medicine
  • Intensive Care Unit Cognitive Disorders
  • Obstructive Sleep Apnea Research
  • Sepsis Diagnosis and Treatment
  • Antibiotic Resistance in Bacteria
  • Pneumonia and Respiratory Infections
  • Endodontics and Root Canal Treatments
  • Neuroscience of respiration and sleep
  • Nosocomial Infections in ICU
  • Cardiac Arrest and Resuscitation
  • Cardiac, Anesthesia and Surgical Outcomes
  • Oral and gingival health research
  • Dietary Effects on Health
  • Inhalation and Respiratory Drug Delivery
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Frailty in Older Adults
  • Thermoregulation and physiological responses
  • Dental Radiography and Imaging
  • Oral and Maxillofacial Pathology

Thriasio General Hospital of Elefsina
2012-2025

University of Macedonia
2024-2025

Smile Train
2024

Statistical Service
2024

National and Kapodistrian University of Athens
2009-2023

British Society of Periodontology
2019

Université Libre de Bruxelles
2018

General Hospital of Attica
2002-2017

401 General Military Hospital of Athens
2010

Simanogleio-Amalia Fleming General Hospital
2006-2009

Abstract Introduction The increasing prevalence of multiresistant Gram-negative strains in intensive care units (ICUs) has recently rekindled interest colistin, a bactericidal antibiotic that was used the 1960s for treatment infections caused by bacilli. We conducted present observational study to evaluate efficacy intravenous colistin critically ill patients with sepsis bacilli resistant all other antibiotics. Patients and method Critically antibiotics exception were treated six-bed ICU...

10.1186/cc2358 article EN cc-by Critical Care 2003-07-28

Colistin penetration into the cerebrospinal fluid (CSF) was studied in five critically ill adult patients receiving colistin methanesulfonate for infections by multiresistant gram-negative bacilli. concentrations were determined paired serum and CSF samples, with latter taken lumbar puncture, exception of one patient an external ventriculostomy. CSF-to-serum ratios (0.051 to 0.057) all study coincided at sampling times. The low level (5%) suggests inadequate bactericidal CSF.

10.1128/aac.00345-09 article EN Antimicrobial Agents and Chemotherapy 2009-08-25
Andrew Conway Morris Katharina Köhler Thomas De Corte Ari Ercole Harm‐Jan de Grooth and 95 more Paul Elbers Pedro Póvoa Rui Morais Despoina Koulenti Sameer Jog Nathan D. Nielsen Alasdair Jubb Maurizio Cecconi Jan J. De Waele Marco Bezzi Alicia Gira Philipp Eller Tarikul Hamid Injamam Ull Haque Wim De Buyser Antonella Cudia Daniel De Backer Pierre Foulon Vincent Collin Jan J. De Waele Jolien Van Hecke Elisabeth De Waele Claire Van Malderen Jean-Baptiste Mesland Michaël Piagnerelli Lionel Haentjens Nicolas De Schryver Jan Van Leemput Philippe Vanhove Pierre Bulpa Viktoria Ilieva David Katz Anna Geagea Alexandra Binnie Fernando Tirapegui Gustavo Lago Jerónimo Graf Rodrigo Perez-Araos Patricio Vargas Felipe Martínez Eduardo Labarca Daniel Franco Daniela Parra-Tanoux Luis Felipe Reyes David Yepes Filip Periš Sanda Stojanović Stipić Cynthia Vanessa Campozano Burgos Paulo Roberto Navas Boada Jose Luis Barberan Brun Juan Pablo Paredes Ballesteros Ahmed Hammouda Omar Elmandouh Ahmed Y. Azzam Aliae Mohamed Hussein Islam Galal Ahmed K. Awad Mohammed A. Azab Maged Abdalla Hebatallah Hany Assal Mostafa Alfishawy Sherief Ghozy Samar Tharwat Abdullah Eldaly Veronika Reinhard Anne Chrisment Chrystelle Poyat Julio Badié Fernando Berdaguer Ferrari Björn Weiß Karl Friedrich Kuhn Julius J. Grunow Marco Lorenz Stefan J. Schaller Peter M. Spieth Marc Bota Falk Fichtner Kristina Fuest Tobias Lahmer Johannes Herrmann Patrick Meybohm Νικόλαος Μάρκου Georgia Vasileiadou Evangelia Chrysanthopoulou Panagiotis Papamichalis Ioanna Soultati Sameer Jog Kushal Kalvit Sheila Nainan Myatra Ivan Krupa Aisa Tharwat Alistair Nichol Aine McCarthy Ata Mahmoodpoor Tommaso Tonetti

The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and conditions; however, data have suggested that patterns of these differ between other pneumonitides. This secondary analysis aimed explore co-infection intensive unit-acquired infections (ICU-AI) the relationship use corticosteroids in large, international cohort critically ill patients.

10.1186/s13054-022-04108-8 article EN cc-by Critical Care 2022-08-03

Available data on colistin pharmacokinetics in patients undergoing continuous renal replacement therapy (CRRT) are limited. Our aim was to study critically ill treated with methane sulphonate for Gram-negative sepsis and venovenous haemodiafiltration acute failure. Three were studied. The dose administered at the discretion of attending physician all cases lower than that recommended individuals intact function. Colistin intravenously over 30 min, blood samples collected from each patient...

10.1093/jac/dks257 article EN Journal of Antimicrobial Chemotherapy 2012-07-12
Chahnez Taleb Elisa Gouvêa Bogossian Carla Bittencourt Rynkowski Kirsten Møller Piet Lormans and 95 more Manuel Quintana‐Díaz Anselmo Caricato Luigi Zattera Pedro Kurtz Geert Meyfroidt Hervé Quintard Celeste Dias Angelo Giacomucci Charlotte Castelain Russell Chabanne Pilar Marcos-Neira Stepani Bendel Ahmed Subhy Alsheikhly Mohamed Elbahnasawy Samuel Gay Maximilian D’Onofrio К. А. Попугаев Νικόλαος Μάρκου Pierre Bouzat Jean‐Louis Vincent Fabio Silvio Taccone Marco Antonio Cardoso Ferreira Rafael Badenes Christian Baastrup Søndergaard Kirsten Colpaert Letícia Petterson Claudia I. Diaz Andrés Saravia Ahmad Bayrlee Laura Nedolast Hussam Elkambergy Haamid Siddique Jihad Mallat Nahla AlJaberi Samer Shoshan A Mándi Bruno De Oliveira Malligere Prasanna Rehan Haque Dnyaneshwar Munde Sara Chaffee Fatma Alawadhi Jamil Dibu Eija Junttila Teemu M. Luoto Simona Šteblaj Jacques Créteur D. Durand Caroline Abbenhuijs Nancy Itesa Matumikina Filippo Annoni Leda Nobile Miguel Ulloa Bersatti Igor Yovenko Alexander Tsarev Jasperina Dubois Evy Voets Luc Janssen Luigi Zattera Leire Pedrosa Berta López Ainhoa Serrano Nekane Romero-García Xavier Wittebole Antonio Maria Dell’Anna Camilla Gelormini Eleonora Stival Pilar Marcos-Neira Regina Roig Pineda Lara Bielsa Berrocal Maite Misis Jorge Mejía-Mantilla Ángela Marulanda Wojciech Dąbrowski Rune Damgaard Nielsen Markus Harboe Olsen Helene Ravnholt Jensen Ida Møller Larsen Roberta T. Tallarico Umberto Lucangelo Maria Isabel Gonzalez Perez Carole Ichai Karim Asenhoune Karim Lakhal Charlotte Fernandez-Canal Samuel Gay Marie Lebouc David Bougon Étienne Escudier Michel Sirodot Albrice Levrat Alix Courouau Jacques Duranteau Aurore Rodrigues Naima Makouche

The optimal hemoglobin (Hb) threshold to trigger red blood cell transfusions (RBCT) in subarachnoid hemorrhage (SAH) patients is unclear. This study evaluated the impact of liberal versus restrictive transfusion strategies on neurological outcome with SAH. a pre-planned secondary analysis "TRansfusion Strategies Acute brain INjured Patients" (TRAIN) study. We included all SAH from original that were randomized receive RBCT when Hb levels dropped below 9 g/dL (liberal group) or 7 (restrictive...

10.1186/s13054-025-05270-5 article EN cc-by-nc-nd Critical Care 2025-02-07

Background/Objectives: Individuals with Crohn’s disease often experience challenges at work and are confronted the decision of whether to disclose their health status in workplace. This study explores disclosure workplace factors influencing choices among individuals Greece. Methods: The examined how demographic characteristics affected a non-visible disability, reasons behind disclosure, associated experiences. Results: sample consisted 152 disease. Although 52.6% participants had disclosed...

10.3390/gidisord7010018 article EN cc-by Gastrointestinal Disorders 2025-02-21

Background: Platelet‐rich plasma (PRP) alone or combined with other regenerative materials was previously studied in human periodontal endosseous defects. There are no sufficient data evaluating to what extent the addition of demineralized freeze‐dried bone allograft (DFDBA) PRP may enhance effectiveness PRP. The aim this randomized, double‐masked, controlled clinical trial compare autologous + DFDBA Methods: Twenty‐four proximal defects 24 patients severe chronic periodontitis were randomly...

10.1902/jop.2009.090216 article EN Journal of Periodontology 2009-12-01

<b><i>Background:</i></b> Macrophage activation-like syndrome (MALS) and complex immune dysregulation (CID) often underlie acute respiratory distress (ARDS) in COVID-19. We aimed to investigate the effect of personalized immunotherapy on clinical improvement critical <b><i>Methods:</i></b> In this open-label prospective trial, 102 patients with ARDS by SARS-CoV-2 were screened for MALS (ferritin >4,420 ng/mL) CID ≤4,420 ng/mL low human...

10.1159/000519090 article EN cc-by-nc Journal of Innate Immunity 2021-12-01

<i>Background:</i> Varicella pneumonia is a serious complication of primary varicella infection in adults that often results respiratory failure and death. <i>Objective:</i> To analyze the clinical laboratory manifestations patients admitted to our intensive care unit (ICU). <i>Methods: </i> Retrospective study on treated ICU with diagnosis during period 15 years. We recorded age, gender, smoking habits, findings, arterial blood gases, chest radiograph,...

10.1159/000063274 article EN Respiration 2002-01-01

Shock states are characterized by impaired tissue perfusion and microcirculatory alterations, which directly related to outcome. Skin can be noninvasively evaluated using skin laser Doppler (SLD), which, when coupled with a local thermal challenge, may provide measure of reactivity. We hypothesized that this microvascular reactivity would in patients circulatory shock marker severity. first blood flow (SBF) SLD on the forearm palm 18 healthy volunteers select site maximal response....

10.1186/s13613-018-0393-7 article EN cc-by Annals of Intensive Care 2018-05-03

Abstract Background: Excess mortality associated with the COVID-19 pandemic has been reported in many countries. Our study aim was to examine excess deaths Cyprus during as compared average documented pre-pandemic period. Methods and Findings: We performed exploratory statistical analysis trends of using data tabulations graphical representations. Publicly available by Ministry Health European Statistical Office (Eurostat) were used analyze over a 7-year period (2016-2022). Information...

10.29011/2577-2228.100407 article EN Journal of Community Medicine & Public Health 2024-02-12

Background/Objectives: Individuals with diabetes often experience discrimination and barriers at work are confronted the challenge of deciding whether to disclose their health status in workplace. This study explores disclosure The research was based on a previously developed questionnaire. Methods: Two hundred five persons who were employed Greece participated research. Results: majority participants chose disclose. Demographic characteristics influenced decision, type employment sector...

10.3390/diabetology5060044 article EN cc-by Diabetology 2024-11-08
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