A5065127838- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Immune Response and Inflammation
- Immune responses and vaccinations
- Antibiotic Use and Resistance
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Vaccine Coverage and Hesitancy
- COVID-19 and healthcare impacts
- Hepatitis C virus research
- Emergency and Acute Care Studies
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Inflammation biomarkers and pathways
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- RNA Interference and Gene Delivery
- COVID-19 Impact on Reproduction
- Machine Learning in Healthcare
- Immune Cell Function and Interaction
- Patient Satisfaction in Healthcare
- Urinary Tract Infections Management
Radboud University Medical Center
2018-2024
Radboud University Nijmegen
2018-2024
Radboud Institute for Molecular Life Sciences
2021-2023
University Hospital Bonn
2023
SIB Swiss Institute of Bioinformatics
2022
University of Lausanne
2022
École Polytechnique Fédérale de Lausanne
2022
University Medical Center
2022
Canisius-Wilhelmina Ziekenhuis
2022
Sabin Vaccine Institute
2022
Although inadequate sleep has a proven negative association with health care outcomes, to date, no large-scale studies have examined in general hospital wards.To assess the subjective quantity and quality of identify hospital-related factors associated disturbances hospitalized patients.For this nationwide, single-day, multicenter, cross-sectional, observational study, which took place on February 22, 2017, all hospitals Netherlands were encouraged by word mouth conventional social media...
Background Knowledge on bacterial co-infections in COVID-19 is crucial to use antibiotics appropriately. Therefore, we aimed determine the incidence of co-infections, antibiotic and application antimicrobial stewardship principles hospitalized patients with COVID-19.Methods We performed a retrospective observational study four hospitals (1 university, 2 non-university teaching, 1 non-teaching hospital) Netherlands from March May 2020 including consecutive PCR-confirmed COVID-19. Data first...
Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related severity, complications, and mortality rate. The complement system an important component innate immunity can stimulate inflammation, but its role COVID-19 unknown.A prospective, longitudinal, single center study was performed hospitalized patients with COVID-19. Plasma concentrations factors C3a, C3c, terminal complex (TCC) were assessed at baseline during hospital admission. In...
Abstract The clinical spectrum of COVID-19 varies and the differences in host response characterizing this variation have not been fully elucidated. disease severity correlates with an excessive proinflammatory immune profound lymphopenia. Inflammatory responses according to were explored by plasma cytokine measurements proteomics analysis 147 patients. Furthermore, peripheral blood mononuclear cell production assays whole flow cytometry performed. Results confirm a hyperinflammatory innate...
ObjectivesTo test whether Bacillus Calmette-Guérin (BCG) vaccination would reduce the incidence of COVID-19 and other respiratory tract infections (RTIs) in older adults with one or more comorbidities.MethodsCommunity-dwelling aged 60 years underlying comorbidities no contraindications to BCG were randomized 1:1 placebo followed for 6 months. The primary endpoint was a self-reported, test-confirmed incidence. Secondary endpoints included hospital admissions clinically relevant RTIs (i.e....
Patients with sepsis-after surviving the initial hyperinflammatory phase-display features consistent immunosuppression, including hyporesponsiveness of immunocompetent cells to bacterial agents. Immunosuppression is thought be facilitated by negative regulators toll-like receptors, membrane-bound ST2. We investigated release soluble ST2 (sST2), a decoy receptor that inhibits signaling, during sepsis.The study population comprised 95 patients severe sepsis admitted one two intensive care...
Previous studies have reported on myocardial injury in patients with coronavirus infectious disease 19 (COVID-19) defined as elevated cardiac biomarkers. Whether biomarkers truly represent dysfunction is not known. The aim of this study was to explore the incidence ventricular and assess its relationship biomarker analyses.
Objective To describe clinical characteristics, disease course and outcomes in a large well-documented cohort of hospitalized COVID-19 patients the Netherlands. Methods We conducted multicentre retrospective study The Netherlands including 952 1183 consecutively that were admitted to participating hospitals between March 2nd, 2020, May 22nd, 2020. Clinical characteristics laboratory parameters upon admission during hospitalization collected until July 1 st . Results median age was 69 years...
The mRNA-based BNT162b2 protects against severe disease and mortality caused by SARS-CoV-2 via induction of specific antibody T-cell responses. Much less is known about its broad effects on immune responses other pathogens. Here, we investigated the adaptive induced vaccination various variants responsiveness cells upon stimulation with heterologous stimuli. effective humoral cellular immunity that started to wane after six months. We also observed long-term transcriptional changes in...
While several BCG trials in adults were conducted during the 2019 coronavirus disease epidemic, our data set is most comprehensive to date, because we included serologically confirmed infections addition self-reported positive SARS-CoV-2 test results. We also collected on symptoms for every day 1-year follow-up period, which enabled us characterize detail.
Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is considered to be important for an appropriate immune response against pathogens that enter the lower airways.We studied effects two different TLR agonists relevant respiratory infections in human lung: lipoteichoic acid (LTA; TLR2 agonist, component gram-positive bacteria) and lipopolysaccharide (LPS; TLR4-agonist, gram-negative bacteria).Fifteen healthy subjects were given LPS or LTA: bronchoscope,...
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Lipopolysaccharide (LPS) is ubiquitous in the environment. Inhalation of LPS has been implicated pathogenesis and/or severity several lung diseases, including pneumonia, chronic obstructive pulmonary disease and asthma. Alveolar macrophages are main resident leukocytes exposed to inhaled antigens. To obtain insight into which innate immune pathways become activated within human alveolar upon exposure vivo, we conducted a study eight healthy humans, instilled sterile saline segment by...
<h3>Background</h3> <i>Streptococcus pneumoniae</i> is the most commonly identified pathogen in community-acquired pneumonia (CAP). Myeloid-related protein (MRP) 8/14 a major component of neutrophils that released upon infection or injury. MRP8/14 essential for protective immunity during by variety micro-organisms through its capacity to chelate manganese and zinc. Here, we aimed determine role pneumococcal pneumonia. <h3>Methods</h3> was determined bronchoalveolar lavage fluid (BALF) serum...
The hypercoagulable state observed in COVID-19 could be responsible for morbidity and mortality. In this retrospective study we investigated whether therapeutic anticoagulation prior to infection has a beneficial effect hospitalized patients. This included 1154 patients admitted 6 hospitals the Netherlands between March May 2020. We applied 1:3 propensity score matching evaluate association use clinical outcome, with hospital mortality as primary endpoint. total, 190 (16%) used admission....
Truly patient-centred care needs to be aligned with what patients consider important, and is highly desirable in the first 24 h of an acute admission, as many decisions are made during this period. However, there limited knowledge on matters most phase their hospital stay. The objective study was identify mattered assess patient perspective whether treating doctors were aware this.This a large-scale, qualitative, flash mob study, conducted simultaneously sixty-six hospitals seven countries,...
Background To date, survival data on risk factors for COVID-19 mortality in western Europe is limited, and none of the published studies have used a competing approach. This study aims to identify in-hospital patients Netherlands, considering recovery as risk. Methods In this observational multicenter cohort we included adults with PCR-confirmed SARS-CoV-2 infection that were admitted one five hospitals Netherlands (March May 2020). We performed analysis, presenting cause-specific hazard...
After surviving the initial hyperinflammatory phase, patients with sepsis display features consistent immunosuppression, which renders host susceptible to nosocomial infections, in particular bacterial pneumonia. Suppression of tumorigenicity 2 (ST2) is a negative regulator Toll-like receptor signaling implicated endotoxin tolerance.The present study sought determine role ST2 modulating defense lung during sepsis, using murine model cecal ligation and puncture (CLP)-induced followed by...
Abstract Background Infection with SARS-CoV-2 manifests itself as a mild respiratory tract infection in the majority of individuals, which progresses to severe pneumonia and acute distress syndrome (ARDS) 10-15% patients. Inflammation plays crucial role pathogenesis ARDS, immune dysregulation COVID-19 leading hyperinflammatory response. A comprehensive understanding inflammatory process is lacking. Methods In this prospective, multicenter observational study, patients PCR-proven or...
The Dutch Working Party on Antibiotic Policy (SWAB) in collaboration with relevant professional societies, has updated their evidence-based guidelines empiric antibacterial therapy of sepsis adults.Our multidisciplinary guideline committee generated ten population, intervention, comparison, and outcome (PICO) questions for adult patients sepsis. For each question, a literature search was performed to obtain the best available evidence assessed using Grading Recommendations Assessment,...
Pneumonia is characterized by an acute inflammatory response in the lung, which frequently associated with changes coagulation and fibrinolysis bronchoalveolar space. Here, we compared effects of lipoteichoic acid (LTA), a major cell wall component Gram-positive bacteria, lipopolysaccharide (LPS), human space.Controlled vivo volunteer study.Clinical research unit.Twenty-three healthy nonsmoking male volunteers.Sterile saline was instilled into lung subsegment followed bronchoscopic...