A5012811341- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Imaging and Diagnostics
- Air Quality and Health Impacts
- Cancer-related cognitive impairment studies
- Nutritional Studies and Diet
- Physical Activity and Health
- Acute Myocardial Infarction Research
- COVID-19 Clinical Research Studies
- Breast Cancer Treatment Studies
- Urban Transport and Accessibility
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Obesity, Physical Activity, Diet
- Hip and Femur Fractures
- Coronary Interventions and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Health and Risk Factors
- Inflammasome and immune disorders
- Climate Change and Health Impacts
- Delphi Technique in Research
- Cardiac Valve Diseases and Treatments
- CAR-T cell therapy research
- Environmental Justice and Health Disparities
- Cancer Risks and Factors
- Advancements in Semiconductor Devices and Circuit Design
University Medical Center Utrecht
2023-2025
Utrecht University
2024-2025
Heart Foundation
2025
Radboud University Medical Center
2018-2024
Radboud University Nijmegen
2018-2024
Hersenstichting
2024
Previous studies have reported on myocardial injury in patients with coronavirus infectious disease 19 (COVID-19) defined as elevated cardiac biomarkers. Whether biomarkers truly represent dysfunction is not known. The aim of this study was to explore the incidence ventricular and assess its relationship biomarker analyses.
Although improved breast cancer (BC) treatment has decreased mortality, these anti-cancer regimens may have serious cardiovascular side effects that affect patients' long-term prognosis and quality of life (QoL). BC patients with treatment-related cardiac dysfunction (CTRCD) can suffer from a variety symptoms, such as dyspnoea fatigue. The impact CTRCD after on daily not been qualitatively explored yet.This study aims to explore the influence QoL women BC, defined by concept positive health....
There is much debate on the use of angiotensin receptor blockers (ARBs) in severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected patients. Although it has been suggested that ARBs might lead to a higher susceptibility and severity SARS-CoV-2 infection, experimental data suggest may reduce lung injury via blocking angiotensin-II-mediated pulmonary permeability, inflammation, fibrosis. However, despite these hypotheses, specific studies patients are lacking. METHODS: The...
Self-management support is widely accepted for the management of chronic conditions. often requires behaviour change in patients, which primary care nurses play a pivotal role. To patients changing their behaviour, structured Activate intervention was developed. This aims to enhance physical activity at risk cardiovascular disease as well nurses’ role supporting these patients. study aimed evaluate perceptions towards delivery and feasibility intervention. A qualitative nested within...
Abstract Background Thoracic radiotherapy may damage the myocardium and arteries, increasing cardiovascular disease (CVD) risk. Women with a high local breast cancer (BC) recurrence risk receive an additional radiation boost to tumor bed. Objective We aimed evaluate CVD specifically ischemic heart (IHD) in BC patients treated boost, investigated whether this was modified by age. Methods identified 5260 receiving between 2005 2016 without history of CVD. Boost data were derived from hospital...
Very few studies to date investigated the prospective association of changes in exposure food environment with cardiovascular disease (CVD) risk. We aim explore if time-varying was associated hospitalization and mortality due total specific types CVD The Netherlands.
ObjectiveLower extremity peripheral arterial disease (PAD) is a severe condition that increases the risk of major adverse cardiovascular events, limb and all cause mortality. This study aimed to investigate mortality among females males hospitalised for first time with lower PAD.MethodsThree cohorts patients who were admitted PAD in 2007 – 2010, 2011 2014, 2015 2018 constructed. For 2010 2014 cohorts, 28 day, one year, five year rates calculated, assessing survival from date hospital...
The very long-term outcomes of off-pump versus on-pump Coronary Artery Bypass Grafting (CABG) and Percutaneous Intervention (PCI) are largely unclear. We linked 20-years two randomized trials to evaluate re-intervention mortality for CABG, CABG PCI.
Various breast cancer (BC) treatments, such as chemotherapy and targeted therapies, increase cardiotoxicity-risk lead to premature ischemic heart disease failure among survivors. Reducing this adverse risk through early recognition (preventive) treatment is therefore important. Conversely, we feel that screening for cardiotoxicity currently insufficiently standardized in daily practice. A fundamental first step identifying areas of improvement providing an overview current practice.This...
Breast cancer (BC) patients have an increased risk of developing therapy-related cardiac dysfunction (CTRCD) and cardiovascular morbidity, which seems to a substantial prognostic impact. Oncologists, in collaboration with dedicated cardiologists, the opportunity perform stratification. Despite guideline recommendations, strategies detect damage at early stage are not structurally implemented clinical practice. The perspectives oncology professionals regarding surveillance BC been...
The awareness of cancer therapy-related adverse cardiac effects is fueled by recent literature on cardiotoxicity incidence and detection strategies. Although this influences the sense urgency, in current practice, monitoring treatment not structurally performed. With study, we aimed to evaluate perspectives cardio-oncology assess needs, ultimately determine an agenda for improvements practice.A national multidisciplinary 36-question survey was conducted. developed a team, theoretically based...
Recent randomised clinical trials showed benefit of non-culprit lesion revascularisation in ST-elevation myocardial infarction (STEMI) patients. However, it remains unclear whether should be performed at the index procedure or a later stage.The instantaneous wave-free ratio (iFR) Guided Multivessel Revascularisation During Percutaneous Coronary Intervention for Acute Myocardial Infarction trial is multicentre, controlled prospective open-label with blinded evaluation endpoints. After...
Background: The food environment is suggested as a risk factor of cardiovascular disease (CVD), but current evidence inconsistent and does not account for changes in the environment. We aimed to explore if time-varying exposure was associated with hospitalisation mortality due total specific types CVD Netherlands. hypothesized that favourable trends would be decreased CVD, stroke, heart failure (HF), coronary (CHD) morbidity among Dutch general population. Methods: A prospective cohort study...
Cardiovascular disease (CVD) and cancer are the two leading causes of death worldwide. Given their high prevalence, it is important to understand burden mortality in CVD patients.
Abstract Aims There is an increasing awareness of the evidence-based selection outcomes to be measured in clinical trials and practice. Currently, there no core outcome set (COS) for cardio-oncology, which may hinder (inter)national comparison effectiveness research quality cardio-oncology care. The aim this study develop a standard pragmatic patient-centred assess monitor cancer patients survivors at risk or with cardiovascular diseases. Methods results A list domains was generated through...
Air pollution exposure has been linked to detrimental health outcomes. While cross-sectional studies have demonstrated socioeconomic disparities in air exposure, longitudinal evidence on these remains limited. The current study investigates trends residential across groups the Netherlands from 2014 2019. Our dataset includes over 12.5 million individuals, aged 18 years and above, who resided between 2019, using Statistics data. address-level concentrations were estimated by dispersion models...
Abstract Background Air pollution is a major risk factor for cardiovascular diseases and contributes to health disparities, particularly among minority ethnic groups, who often face higher exposure levels. Knowledge on whether the effect of air differs between groups crucial identifying mechanisms underlying ultimately informing targeted public strategies interventions. We explored differences in associations ischemic stroke heart disease (IHD) six largest Netherlands. Methods This...
Abstract Background Cardiovascular disease (CVD) and cancer are the two leading causes of death worldwide. The relationship between diseases is complex multi-factorial, with both sharing risk factors influencing each other's pathogenesis progression. Given this interaction high prevalence CVD cancer, it crucial to understand impact incidence on mortality evaluate which patients at highest risk. This study aims cardiovascular have a higher malignancy-related mortality, stratified for type...
Abstract Background Breast cancer (BC) is the most common type of in women. Over past decades survival rates increased up to 90% at 5 years and 83% 10 years. The various BC treatments, such as radiotherapy, chemotherapy immunotherapy increase cardiotoxicity risk, leading premature ischemic heart disease failure amongst survivors. Both affect women's daily routine quality life. Reducing this adverse by early recognition (preventive) treatment, therefore important. Despite, screening for...