A5074842239- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Infective Endocarditis Diagnosis and Management
- Advanced MRI Techniques and Applications
- Cardiovascular and exercise physiology
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Airway Management and Intubation Techniques
- Dental materials and restorations
- Cardiac Health and Mental Health
- Heart rate and cardiovascular health
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Breast Cancer Treatment Studies
- Tracheal and airway disorders
- Liver Disease and Transplantation
- Chemotherapy-induced cardiotoxicity and mitigation
- Coronary Interventions and Diagnostics
- Systemic Sclerosis and Related Diseases
- Gout, Hyperuricemia, Uric Acid
- Endodontics and Root Canal Treatments
Radboud University Medical Center
2020-2024
University Medical Center
2021-2024
Radboud University Nijmegen
2020-2024
Werkgroep Cardiologische centra Nederland
2021
Mitral annular disjunction is the atrial displacement of mural mitral valve leaflet hinge point within atrioventricular junction. Said to be associated with malignant ventricular arrhythmias and sudden death, its prevalence in general population not known.The purpose this study was assess frequency occurrence extent a large cohort.The authors assessed cardiac magnetic resonance (CMR) images 2,646 Caucasian subjects enrolled UK Biobank imaging study, measuring length at 4 points around...
Systemic sclerosis (SSc) is characterized by vasculopathy, inflammation, and fibrosis, carries one of the worst prognoses if patients also develop pulmonary arterial hypertension (PAH). Although PAH a known prognosticator, with SSc-PAH demonstrate disproportionately high mortality, presumably due to cardiac involvement. In this cross-sectional study, relationship between involvement revealed cardiovascular magnetic resonance (CMR) systemic microvascular disease severity measured nailfold...
Aortic valve stenosis (AS), the leading valvular disease in aging populations, is driven by complex extracellular matrix (ECM) modifications and progressive calcification. Despite its clinical significance, molecular mechanisms underlying AS remain poorly understood, limiting therapeutic options to invasive replacement. This study employs Raman microscopy, a label-free imaging technique, integration with transmission electron microscopy (TEM) elucidate biochemical ultrastructural changes...
The Low-Dose Colchicine-2 (LoDoCo2) trial showed that 2–4 years exposure to colchicine 0.5 mg once daily reduced the risk of cardiovascular events in patients with chronic coronary artery disease. potential effect years-long on renal or liver function and creatine kinase (CK) has not been systematically evaluated was investigated this LoDoCo2 substudy. Blood samples drawn from 1776 participants at close-out visit were used measure markers (creatinine, blood urea nitrogen [BUN]), (alanine...
Abstract Aims Paravalvular regurgitation (PVR) is a common complication after transcatheter aortic valve replacement (TAVR) that poses an increased risk of rehospitalization for heart failure and mortality. The aim this study was to assess the accuracy haemodynamic indices predict relevant PVR. Methods results In prospective single-centre clinical trial, four PVR measured during TAVR were assessed their correlation with gold standard cardiac magnetic resonance (CMR)-derived regurgitant...
Abstract Background Thoracic radiotherapy may damage the myocardium and arteries, increasing cardiovascular disease (CVD) risk. Women with a high local breast cancer (BC) recurrence risk receive an additional radiation boost to tumor bed. Objective We aimed evaluate CVD specifically ischemic heart (IHD) in BC patients treated boost, investigated whether this was modified by age. Methods identified 5260 receiving between 2005 2016 without history of CVD. Boost data were derived from hospital...
Accurate risk stratification identifying patients with hypertension at of future cardiovascular disease in primary care would be desirable.
Objectives To investigate: (1) the prevalence of left ventricular hypertrophy (LVH) in elderly primary care patients with long-standing asymptomatic hypertension, and (2) diagnostic value ECG as a screening tool detection LVH compared echocardiography this specific patient population. Design settings A cross-sectional study five general practices south-east Netherlands. Participants Patients care-managed aged between 60 85 years, without known heart failure. Primary secondary outcome...
Vascular complications are among the most commonly observed after TAVI. Iliofemoral vascular outcome has been described extensively. Little is known about in transaxillary The aim of current study was to describe incidence and predictors axillary artery incorporating computed tomography angiography (CTA) measurements.CT analysis performed two hundred patients treated with TAVI our centre between January 2014 December 2017. occurred 37 (18.5%) patients. Patient characteristics predicting this...
What is known and Objective: The increased central sympathetic activity typically associated with chronic heart failure (CHF) probably mediated by formation of reactive oxygen species (ROS) in the brain. Our objective was to undertake a trial test our hypothesis that administration well-known antioxidant ROS scavenger ascorbic acid, would reverse or reduce overactivity CHF patients. Methods: In prospective, randomized, placebo-controlled, double-blind, cross-over trial, 11 patients were...
Mitral annular abscesses are rare and can be caused by infective endocarditis. We present the case of a patient with an infected mitral prosthesis, multiple suspected periprosthetic abscesses. However, perioperative inspection showed supra-annular implanted prosthesis.
Abstract Funding Acknowledgements Type of funding sources: None. Background Paravalvular regurgitation (PVR) is a common complication after transcatheter aortic valve replacement (TAVR) that poses an increased risk rehospitalization for heart failure and mortality. Two-dimensional (2D) cardiac magnetic resonance (CMR) quantitative flow assessment the gold standard evaluation PVR TAVR. Two novel techniques in are 2D multi-velocity encoding (Venc) four-dimensional (4D) flow. The multi-venc...
Abstract Background Paravalvular regurgitation (PVR) is a common complication after transcatheter aortic valve replacement (TAVR) which poses an increased risk of rehospitalization for heart failure and mortality. Purpose To assess the accuracy hemodynamic indices to detect relevant PVR as compared gold-standard cardiac magnetic resonance (CMR) quantitative flow assessment. Methods In this prospective single-centre clinical trial, four measured directly TAVR were assessed their correlation...