A5102759269- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Coronary Artery Anomalies
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Radiology practices and education
- Lung Cancer Treatments and Mutations
- Aortic Disease and Treatment Approaches
- Medical Imaging and Pathology Studies
- Cardiovascular Issues in Pregnancy
- COVID-19 diagnosis using AI
- Medical Imaging Techniques and Applications
- Sympathectomy and Hyperhidrosis Treatments
- Gynecological conditions and treatments
- Dermatologic Treatments and Research
- Bacterial Identification and Susceptibility Testing
- Nerve Injury and Rehabilitation
- Connective Tissue Growth Factor Research
- Cardiac Valve Diseases and Treatments
Radboud University Nijmegen
2014-2024
Radboud University Medical Center
2013-2024
University Medical Center
2019-2024
Meander Medisch Centrum
2015-2019
Beth Israel Deaconess Medical Center
2015
To examine the factors that affect inter- and intraobserver agreement for pulmonary nodule type classification on low-radiation-dose computed tomographic (CT) images, their potential effect patient management.Nodules (n = 160) were randomly selected from Dutch-Belgian Lung Cancer Screening Trial cohort, with equal numbers of types similar sizes. Nodules scored by eight radiologists using morphologic categories proposed Fleischner Society guidelines management nodules as solid, part solid a...
Purpose: The amount of coronary artery calcification (CAC) is a strong and independent predictor cardiovascular disease (CVD) events. In clinical practice, CAC manually identified automatically quantified in cardiac CT using commercially available software. This tedious time-consuming process large-scale studies. Therefore, number automatic methods that require no interaction semiautomatic very limited for the identification have been proposed. Thus far, comparison their performance has...
To evaluate the added value of computer-aided detection (CAD) for lung nodules on chest radiographs when radiologists have bone-suppressed images (BSIs) available.Written informed consent was waived by institutional review board. Selection study and setup reviewed approved boards. Three hundred posteroanterior (PA) lateral (189 with negative findings 111 a solitary nodule) in 300 subjects were selected from image archives at four institutions. PA processed using commercially available CAD,...
Women with Turner syndrome (TS) are at increased risk of aortic dissection, which is related to ascending diameter. However, the relation between diameter and outcome not well determined. This study evaluates prevalence dilatation, growth rate aorta complications in adults TS.Single centre, retrospective all women TS followed a strict protocol an outpatient clinic. Aortic diameters were analysed using advanced imaging. The primary was combined endpoint aortic-related mortality, dissection...
Background Dual-energy CT iodine maps are used to detect pulmonary embolism (PE) with angiography but require dedicated hardware. Subtraction CT, a software-only solution, results in high contrast-to-noise ratios. Purpose To compare the use of subtraction versus dual-energy for PE detection. Materials and Methods In this prospective study ( https://clinicaltrials.gov , NCT02890706), 274 participants suspected having underwent precontrast followed by contrast material-enhanced between July...
<h3>Background</h3> Autologous haematopoietic stem cell transplantation (HSCT) improves survival in systemic sclerosis (SSc) with poor prognosis, but is hampered by treatment-related mortality (TRM). <h3>Objective</h3> To evaluate event-free (EFS), TRM, response to treatment, disease progression and patient characteristics associated events. <h3>Methods</h3> All patients treated HSCT for SSc The Netherlands until 2017 (n=92) were included. Data on skin involvement (modified Rodnan score...
Abstract Right ventricular (RV) ejection fraction (EF) by cardiac magnetic resonance (CMR) correlates to outcome in precapillary pulmonary hypertension (pPH) patients, but is insensitive early changes. Strain might provide incremental information. In this study, we compare right atrial (RA) and RV strain pPH patients healthy controls, evaluate the prognostic value of pPH. cross-sectional 45 20 controls underwent CMR, feature-tracking derived RA were evaluated. had impaired reservoir conduit...
Systemic sclerosis (SSc) is characterized by vasculopathy, inflammation, and fibrosis, carries one of the worst prognoses if patients also develop pulmonary arterial hypertension (PAH). Although PAH a known prognosticator, with SSc-PAH demonstrate disproportionately high mortality, presumably due to cardiac involvement. In this cross-sectional study, relationship between involvement revealed cardiovascular magnetic resonance (CMR) systemic microvascular disease severity measured nailfold...
In lung cancer patients with multiple lesions, the differentiation between metastases and second primary tumours has significant therapeutic prognostic implications. The aim of this retrospective study was to investigate potential (18)F-FDG PET discriminate metastatic disease from tumours.Of 1,396 evaluated by thoracic oncology group January 2004 April 2009 at Radboud University Nijmegen Medical Centre, a synchronous were selected. Patients involving lungs served as control group. Maximum...
Purpose To compare human observers to a mathematically derived computer model for differentiation between malignant and benign pulmonary nodules detected on baseline screening computed tomography (CT) scans. Methods A case-cohort study design was chosen. The group consisted of 300 chest CT scans from the Danish Lung Cancer Screening Trial (DLCST). It included all with proven malignancies (n = 62) two subsets randomly selected sizes 120) matched in size cancers, respectively 118). Eleven...
Objective Women with Turner syndrome (TS) are at increased risk of aortic dissection, which is a life-threatening event associated dilation. Knowledge on the development dilation over time remains limited. This study aims to describe prevalence dilation, find factors and growth in women TS. Methods In this prospective multicentre cohort study, consecutive adult genetically proven TS included between 2014 2016 underwent ECG-triggered multiphase CT angiography baseline after 3 years. Aortic...
Systemic sclerosis (SSc) is a generalised autoimmune disease that causes morbidity and reduced life expectancy. Recently, evidence has been accumulating immunosuppressive treatment in an early stage of the could improve survival, enhancing need for diagnosis regular evaluation organ involvement. Among others, high-resolution computer tomography (HRCT) scan chest performed assessment pulmonary involvement SSc. The objective this study to evaluate predictive value oesophageal dilatation on...
<h3>Background:</h3> Thoracic paravertebral block is regularly used for unilateral chest and abdominal surgery associated with a low complication rate. <h3>Case Reports:</h3> We describe 2 patients an ipsilateral brachial plexus Horner syndrome after high continuous thoracic at T2-3. One patient also developed hemidiaphragmatic paresis, adverse effect that has not been reported before. Subsequent radiologic examination revealed limited cephalad spread of the radiopaque dye laterally...
Pulmonary arterial (PA) flow is abnormal after the Fontan operation and marked by a lack of pulsatility. We assessed effects this on size function PA’s in patients long-term serial follow-up. Twenty-three with follow-up were included. Median age was 11.1 (9.5–16.0) years at baseline 15.5 (12.5–22.7) duration 4.4 (4.0–5.8) years. Flow left pulmonary artery determined using phase-contrast MRI. From wall shear stress (WSS), distensibility pulsatility determined. A group healthy peers included...
To determine the influence of local contrast optimisation on diagnostic accuracy and perceived suspiciousness digital screening mammograms.Data were collected from a region in Netherlands consisted 263 cases (153 recalled,110 normal). Each case was available twice, once processed with tissue equalisation (TE) algorithm (PV). All had digitised previous mammograms. For both algorithms, probability malignancy each finding scored independently by six radiologists. Perceived defined as highest...
Right ventricular (RV) function is of particular importance in systemic sclerosis (SSc), since common SSc complications, such as interstitial lung disease and pulmonary hypertension may affect RV afterload. Cardiovascular magnetic resonance (CMR) the gold standard for measuring function. CMR-derived right atrial (RA) strain a promising tool to detect subtle changes function, might have incremental value, however, prognostic data lacking. Therefore, aim this study was evaluate value RA SSc.In...
This study aimed to determine whether lower values of feature-tracking cardiovascular magnetic resonance (CMR)-derived left atrial reservoir strain (LARS) and impaired ventricular (LV) global longitudinal (GLS) were associated with the presence symptoms long-term prognosis in patients SSc.A total 100 {54 [interquartile range (IQR) 46-64] years, 42% male} SSc who underwent CMR imaging at two tertiary referral centres included. All analysis LARS LV GLS using on followed-up for occurrence...
Objective Chest radiographs (CXR) are an important diagnostic tool for the detection of invasive pulmonary aspergillosis (IPA) in critically ill patients, but their value is limited by a poor sensitivity. By using advanced image processing, aim this study was to increase chest work up neutropenic patients who suspected IPA. Methods The frontal CXRs 105 cases IPA were collected from four institutions. Radiographs could contain single or multiple sites infection. CT used as reference standard....
Dynamic myocardial computed tomography perfusion (CTP) is a novel imaging technique that increases the applicability of CT for cardiac imaging; however, scanning requires substantial radiation dose.