A5014214613- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
- EEG and Brain-Computer Interfaces
- Aortic Disease and Treatment Approaches
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Genetic Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Imaging and Diagnostics
- Transcranial Magnetic Stimulation Studies
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Stroke Rehabilitation and Recovery
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Functional Brain Connectivity Studies
- Vascular Malformations Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Cardiac Arrest and Resuscitation
- MRI in cancer diagnosis
University of Amsterdam
2015-2024
Amsterdam University Medical Centers
2018-2024
Amsterdam Neuroscience
2015-2024
Ambulance Care (Sweden)
2023
Amsterdam UMC Location University of Amsterdam
2012-2019
Purpose To assess the accuracy and precision of a volumetric wall shear stress (WSS) calculation method applied to cine phase contrast magnetic resonance imaging (PC‐MRI) data. Materials Methods Volumetric WSS vectors were calculated in software phantoms. algorithm parameters optimized influence spatial resolution segmentation was evaluated. Subsequently, 2D PC‐MRI data carotid aorta at varying resolutions obtained ( n = 2) compared with simulations. Finally, 3D bifurcation 6). Results We...
Purpose To investigate the reproducibility and interobserver variability of 3D aortic velocity vector fields wall shear stress (WSS) averaged over five systolic timeframes derived from noncontrast 4D flow magnetic resonance imaging (MRI). Materials Methods Fourteen controls underwent test-retest MRI examinations separated by 16 ± 3 days (resolution = 3.0–3.6 × 2.3–2.6 2.5–2.7 mm3; TE/TR/FA 2.5/4.9 msec/7°; Venc 150 cm/s). Two observers segmented aorta, WSS was calculated for both series...
Purpose To compute cohort-averaged wall shear stress (WSS) maps in the thoracic aorta of patients with aortic dilatation or valvular stenosis and to detect abnormal regional WSS. Methods Systolic WSS vectors, estimated from four-dimensional flow MRI data, were calculated along lumen 10 controls, dilated aortas, valve stenosis. Three-dimensional segmentations each coregistered by group used create a cohort-specific geometry. The vectors subject interpolated onto corresponding geometry maps. A...
<h3>BACKGROUND AND PURPOSE:</h3> Attempts have been made to associate intracranial aneurysmal hemodynamics with aneurysm growth and rupture status. Hemodynamics in aneurysms is traditionally determined computational fluid dynamics by using generalized inflow boundary conditions a parent artery. Recently, patient-specific are being implemented more frequently. Our purpose was compare based on versus conditions. <h3>MATERIALS METHODS:</h3> For 36 patients, geometric models of were 3D...
Purpose To investigate age‐related changes in peak systolic aortic 3D velocity and wall shear stress (WSS) healthy controls to the importance of age‐matching for mapping abnormal hemodynamics bicuspid valve disease (BAV). Materials Methods 4D flow MRI (fields strengths = 1.5–3T; resolution 2.2–3.9 × 1.7–2.6 2.2–4.0 mm 3 ; Venc 150–250 cm/s; TE/TR/FA 2.3–2.8/4.7–5.4msec/7–15°) was performed 56 (age range: 19–78 years) two BAV patient groups each consisting 10 subjects (group 1: 20–29 years,...
To evaluate wall shear stress (WSS) estimations in an vitro and vivo intracranial aneurysm, WSS was estimated from phase contrast magnetic resonance imaging (PC-MRI) compared with computational fluid dynamics (CFD).First, using a high-resolution PC-MRI measurement under steady pulsatile flow conditions CFD simulations. Second, data acquired at different spatial resolutions. Third, were CFD. The direction magnitude of vectors computed compared.Quantitative agreement between CFD-based moderate...
Wall shear stress (WSS) is involved in many pathophysiological processes related to cardiovascular diseases, and knowledge of WSS may provide vital information on disease progression. generally quantified with computational fluid dynamics (CFD), but can also be calculated using phase contrast MRI (PC‐MRI) measurements. In this study, our objectives were calculate the entire luminal surface human carotid arteries PC‐MRI velocities (WSS ) compare it based CFD ). Six healthy volunteers scanned...
Endovascular thrombectomy (EVT) is standard treatment for anterior large vessel occlusion stroke (LVO-a stroke). Prehospital diagnosis of LVO-a would reduce time to EVT by allowing direct transportation an EVT-capable hospital. We aim evaluate the diagnostic accuracy dry electrode EEG detection in prehospital setting.
Wall shear stress (WSS) and oscillatory index (OSI) are associated with atherosclerotic disease. Both parameters derived from blood velocities, which can be measured phase-contrast MRI (PC-MRI). Limitations in spatiotemporal resolution of PC-MRI known to affect these measurements. Our aim was investigate the effect using a carotid artery phantom.A phantom connected flow set-up supplying pulsatile flow. measurement planes were placed at common (CCA) internal (ICA). Two-dimensional...
Objective Develop and validate models that predict mortality of patients diagnosed with COVID-19 admitted to the hospital. Design Retrospective cohort study. Setting A multicentre across 10 Dutch hospitals including from 27 February 8 June 2020. Participants SARS-CoV-2 positive (age ≥18) Main outcome measures 21-day all-cause evaluated by area under receiver operator curve (AUC), sensitivity, specificity, predictive value negative value. The age was explored comparison age-based rules used...
<h3>BACKGROUND AND PURPOSE:</h3> Rupture risk of intracranial aneurysms may depend on hemodynamic characteristics. This has been assessed by comparing data ruptured and unruptured aneurysms. However, aneurysm geometry change before, during, or just after rupture; this difference causes potential changes in hemodynamics. We hemodynamics a series aneurysms, using 3D imaging before rupture. <h3>MATERIALS METHODS:</h3> For 9 patients, we used MRA, CTA, rotational angiography rupture to generate...
To investigate whether somatosensory evoked potential (SSEP) amplitude adds information for prediction of poor outcome in postanoxic coma.In this retrospective cohort study we included adult patients admitted after cardiac arrest between January 2010 and June 2018 who remained coma had SSEP recorded prognostication. Outcome was dichotomized (Cerebral Performance Category (CPC) 4-5) good (CPC 1-3) at ICU discharge. Sensitivity bilaterally absent N20 calculated. In case the not absent,...
Abstract Objectives To prospectively compare ultrasound (US) and whole-body MRI for detection of muscle abnormalities compatible with idiopathic inflammatory myopathies (IIM). Methods Newly diagnosed IIM patients underwent US (14 muscles) (36 at diagnosis after nine weeks monotherapy intravenous immunoglobulin. Muscles were when quantitative echo-intensity (EI) z scores was ≥1.5, semi-quantitative Heckmatt score ≥2, qualitative abnormal, or showed oedema on T2-weighted images. At patient...
Evaluate the effect of artifact rejection on performance a Convolutional Neural Network (CNN) based algorithm for classification abnormal and normal electroencephalography (EEG) data. We developed an automated CNN-based clean versus applied this to EEG Additionally, algorithms were with without beforehand. For each algorithm, five CNNs trained using 5-fold cross-validation majority vote these was used test compared bootstrap accuracies number training epochs required between scenario in...
Background The role of kidney hypoxia is considered pivotal in the progression chronic disease. A widely used method to assess oxygenation blood oxygen level dependent ( BOLD )–magnetic resonance imaging MRI ), but its interpretation remains problematic. ‐ signal result consumption (a proxy glomerular filtration) and supply (ie, perfusion). Therefore, we hypothesized that with pharmacological modulation flow, renal oxygenation, as assessed by , correlates filtration fraction rate/effective...
BackgroundNotwithstanding the large improvement in motor function Parkinson's disease (PD) patients treated with deep brain stimulation (DBS), apathy may increase. Postoperative cannot always be related to a dose reduction of dopaminergic medication and itself play role.ObjectiveWe studied whether DBS-treated PD could effect.MethodsIn 26 we acquired scores before >6 months after DBS subthalamic nucleus (STN). Magnetoencephalography recordings (ON OFF stimulation) were performed ≥6 placement....
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established symptomatic treatment in Parkinson's disease, yet its mechanism action not fully understood. Locally STN, lowers beta band power, parallel with symptom relief. Therefore, oscillations are sometimes referred to as “anti-kinetic”. However, recent studies functional interactions have been observed beyond which we hypothesized reflect clinical effects DBS. Resting-state, whole-brain magnetoencephalography (MEG)...
Abstract Background Prehospital detection of large vessel occlusion stroke the anterior circulation (LVO-a) would enable direct transportation these patients to an endovascular thrombectomy (EVT) capable hospital. The ongoing ELECTRA-STROKE study investigates diagnostic accuracy dry electrode electroencephalography (EEG) for LVO-a in prehospital setting. To determine which EEG features are most useful this purpose and assess data quality, recordings also performed emergency room (ER). Here,...
Cardiovascular magnetic resonance (CMR) allows for non-invasive assessment of arterial stiffness by means measuring pulse wave velocity (PWV). PWV can be calculated from the time shift between two time-resolved flow curves acquired at locations within an segment. These derived two-dimensional CINE phase contrast CMR (2D PC CMR). While CMR-derived measurements have proven to accurate aorta, this is more challenging smaller arteries such as carotids due need both high spatial and temporal...