A5071567038- COVID-19 Clinical Research Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- COVID-19 diagnosis using AI
- Electrolyte and hormonal disorders
- Porphyrin and Phthalocyanine Chemistry
- Nanoplatforms for cancer theranostics
- Potassium and Related Disorders
- Intensive Care Unit Cognitive Disorders
- Neuroendocrine regulation and behavior
- Disaster Response and Management
- Rabies epidemiology and control
- Sarcoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Autopsy Techniques and Outcomes
- Sepsis Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Diphtheria, Corynebacterium, and Tetanus
- Esophageal and GI Pathology
- Photodynamic Therapy Research Studies
- Drug Transport and Resistance Mechanisms
Medisch Centrum Alkmaar
2023
Flevoziekenhuis
2006-2021
University of Amsterdam
2018
Amsterdam UMC Location University of Amsterdam
2014-2018
Validated clinical risk scores are needed to identify patients with COVID-19 at of severe disease and guide triage decision-making during the pandemic. The objective current study was evaluate performance early warning (EWS) in ED when identifying who will require intensive care unit (ICU) admission for high-flow-oxygen usage or mechanical ventilation.Patients a proven SARS-CoV-2 infection complete resuscitate orders treated nine hospitals between 27 February 30 July 2020 needing hospital...
Objective Develop and validate models that predict mortality of patients diagnosed with COVID-19 admitted to the hospital. Design Retrospective cohort study. Setting A multicentre across 10 Dutch hospitals including from 27 February 8 June 2020. Participants SARS-CoV-2 positive (age ≥18) Main outcome measures 21-day all-cause evaluated by area under receiver operator curve (AUC), sensitivity, specificity, predictive value negative value. The age was explored comparison age-based rules used...
Cholestasis impairs liver regeneration following partial resection (PHx). Bile acid receptor farnesoid X-receptor (FXR) is a key mediator of regeneration. The effects FXR agonist obeticholic (OCA) on (re)growth were therefore studied in cholestatic rats. Animals underwent sham surgery or reversible bile duct ligation (rBDL). PHx with concurrent internal biliary drainage was performed 7 days after rBDL. untreated received OCA (10 mg/kg/day) per oral gavage from rBDL until sacrifice. After...
Liver regeneration following partial hepatectomy (PHx) is a complicated process involving multiple organs and several types of signaling networks. The bile acid-activated metabolic pathways occupy an auxiliary yet important chapter in the entire biochemical story. PHx characterized by rapid but transient acid overload liver, which constitutes first wave proliferative remnant hepatocytes. Bile acids trigger hepatocyte proliferation through activation nuclear receptors. Following biliary...
Summary Clinical and pathological diagnoses were compared in a prospective study of 145 dogs. A diagnostic work up had been performed on all dogs which 36 (24.8%) died 109 (75.2%) euthanatized. In 119 (82.1%) both clinical patholical diagnosis was made, 20 (13.8%) no could be made 6 (4.1%) established. the agreement level between scored bij referring veterinarian together with pathologist. Total found 61 cases (51.3%) disagree‐ ment 31 (26.0%). remaining (27=22.7%) further specified...
Objectives To evaluate the relationship among dysnatraemia at hospital presentation and duration of admission, risk intensive care unit (ICU) admission all-cause mortality to assess underlying pathophysiological mechanism hyponatraemia in patients with COVID-19. Our hypothesis is that both hypernatraemia are associated adverse outcomes. Design Observational study. Setting Secondary care; 11 Dutch hospitals (2 university 9 general hospitals). Participants An analysis was performed within...
Objectives The aim of this multicentre COVID-PREDICT study (a nationwide observational cohort that aims to better understand clinical course COVID-19 and predict which patients should receive treatment type care) was determine the association between atrial fibrillation (AF) mortality, intensive care unit (ICU) admission, complications discharge destination in hospitalised patients. Setting Data from a historical eight hospitals (both academic non-academic) Netherlands January 2020 July 2021...
Endometrial cancer can give rise to hematogenous metastases, most often in lungs, brain, and bones. We describe a patient with metastases of endometrial the small bowel.
Drainage affects inflammatory and fibrotic gene signatures
ABSTRACT Objective Develop and validate models that predict mortality of SARS-CoV-2 infected patients admitted to the hospital. Design Retrospective cohort study Setting A multicenter across ten Dutch hospitals including from February 27 June 8 2020. Participants positive (age ≥ 18) Main Outcome Measures 21-day evaluated by area under receiver operatory curve (AUC), sensitivity, specificity, predictive value negative value. The age was explored comparison with age-based rules used in...
The incidence of psychotic disorders is increased among men and culminates in adolescence. After menopause, there a second peak the women. It has therefore been suggested that sex steroids, such as oxytocin testosterone, may confer decreased or risks for disorders. To investigate differences peripheral testosterone plasma levels patients with first episode, their unaffected siblings healthy controls. Plasma hormone assays were obtained from 85 disorder, 27 59 Sex-hormone binding globulin...
Background and aim: A photosensitizer (PS) delivery comprehensive tumor targeting platform was developed that is centered on the photosensitization of key pharmacological targets in solid tumors (cancer cells, vascular endothelium, cellular non-cellular components microenvironment) before photodynamic therapy (PDT). Interstitially targeted liposomes (ITLs) encapsulating zinc phthalocyanine (ZnPC) aluminum (AlPC) were for passive microenvironment. In previous work it established PEGylated...