A5040415681- Cardiac, Anesthesia and Surgical Outcomes
- Frailty in Older Adults
- Hemodynamic Monitoring and Therapy
- Blood transfusion and management
- Aortic aneurysm repair treatments
- Colorectal Cancer Surgical Treatments
- Hip and Femur Fractures
- Erythropoietin and Anemia Treatment
- Enhanced Recovery After Surgery
- Nutrition and Health in Aging
- Antiplatelet Therapy and Cardiovascular Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Imaging and Diagnostics
- COVID-19 and healthcare impacts
- Peripheral Artery Disease Management
- COVID-19 Clinical Research Studies
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Cardiac and Coronary Surgery Techniques
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Delphi Technique in Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
St. Antonius Ziekenhuis
2016-2025
University Medical Center Utrecht
2017-2025
Utrecht University
2023-2025
Heidelberg University
2025
University Hospital Heidelberg
2025
Leiden University
2024
Amphia Ziekenhuis
2022
Nieuwegein Fonds
2016-2022
Pain and Rehabilitation Medicine
2015-2021
Haga Hospital
2015
To determine the relationship between preoperative glucose levels and perioperative mortality in noncardiac, nonvascular surgery.We performed a case-control study cohort of 108 593 patients who underwent noncardiac surgery at Erasmus MC during 1991-2001. Cases were 989 elective died within 30 days hospital stay. From remaining patients, 1879 matched controls (age, sex, calendar year, type surgery) selected. Information was obtained regarding presence cardiac risk factors, medication,...
Background Few data are available that systematically describe rates and trends of postoperative mortality for fairly large, unselected patient populations. Methods This population-based study uses a registry 3.7 million surgical procedures in 102 hospitals The Netherlands during 1991-2005. Patients older than 20 yr who underwent an elective, nonday case, open procedure were enrolled. Patient included main (discharge) diagnosis, secondary diagnoses, dates admission discharge, death...
To assess the association of systemic inflammation and outcome after major abdominal surgery.Major surgery carries a high postoperative morbidity mortality rate. Studies suggest that is associated with unfavorable outcome.Levels C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α inflammatory response syndrome (SIRS) were assessed in 137 patients undergoing surgery. Blood samples drawn on days 0, 1, 3, 7, SIRS was scored during 48 hours Primary composite mortality,...
Anemia in cardiac surgery patients has been associated with poor outcomes. Transfusion of red blood cells during is common practice for perioperative anemia, but may come risks. Little known about the association between intra-operative transfusion and mortality undergoing surgery.Single centre historical cohort study 2933 adult coronary or without aortic valve replacement from June 2011 until September 2014. To estimate odds ratio receiving transfusion, a propensity score based logistic...
Introduction Major surgery triggers an innate immune response that can become excessive, leading to suppression and increased risk of infection. Neutrophils are crucial in this response, changes their phenotype associated with the severity response. This study examines effect major on neutrophil phenotypes using fully automated flow cytometry. Methods In prospective single-center cohort study, adult patients undergoing either pancreaticoduodenectomy or on-pump coronary artery bypass grafting...
Abstract Background The TRACE (Routine posTsuRgical Anaesthesia visit to improve patient outComE) RCT did not show any perioperative benefit from ward-based visits by anaesthetists after surgery. aim of this study was evaluate the impact intervention on longer-term outcomes. Methods Patients were followed up in 1 year nine hospitals Netherlands. undergoing elective non-cardiac surgery, and at risk for adverse postoperative outcome, included. group additionally received routine anaesthesia...
Early warning system (EWS) scores are implemented on surgical wards to identify patients at high risk of postoperative clinical deterioration, but its predictive value in older is unclear. This study assessed the prognostic EWS predict severe complications compared younger patients. utilized data from TRACE study. were routinely measured days one (POD1) and three (POD3). The cohort was divided by age: < 70 years ≥ years. Performance measures POD1 POD3 complications. Missed event rates...
Mortality after hospitalization with community-acquired pneumonia (CAP) is high, compared age-matched controls. Available evidence suggests a strong link cardiovascular disease. Our aim was to explore the prognostic value of high-sensitivity cardiac troponin T (cTnT) for mortality in patients hospitalized CAP.CTnT level on admission measured (assay conducted 2015) 295 CAP who participated randomized placebo-controlled double-blind trial adjunctive dexamethasone treatment. Outcome measures...
The study aimed to describe the serosal microcirculation of human bowel using sidestream dark field imaging, a microscopic technique polarized light visualize erythrocytes through capillaries. We also compared its feasibility current practice sublingual microcirculatory assessment.In 17 patients measurements were performed during gastrointestinal surgery. Microcirculatory parameters like microvascular flow index (MFI), proportion perfused vessels (PPV), vessel density (PVD) and total (TVD)...
Validated clinical risk scores are needed to identify patients with COVID-19 at of severe disease and guide triage decision-making during the pandemic. The objective current study was evaluate performance early warning (EWS) in ED when identifying who will require intensive care unit (ICU) admission for high-flow-oxygen usage or mechanical ventilation.Patients a proven SARS-CoV-2 infection complete resuscitate orders treated nine hospitals between 27 February 30 July 2020 needing hospital...
Objective Develop and validate models that predict mortality of patients diagnosed with COVID-19 admitted to the hospital. Design Retrospective cohort study. Setting A multicentre across 10 Dutch hospitals including from 27 February 8 June 2020. Participants SARS-CoV-2 positive (age ≥18) Main outcome measures 21-day all-cause evaluated by area under receiver operator curve (AUC), sensitivity, specificity, predictive value negative value. The age was explored comparison age-based rules used...
Abstract Aims Cardiac morbidity and mortality is high in patients undergoing high‐risk surgery. This study investigated whether impaired glucose regulation elevated glycated haemoglobin (HbA 1c ) levels are associated with increased cardiac ischaemic events vascular surgery patients. Methods Baseline HbA were measured 401 Glucose < 5.6 mmol/l was defined as normal. Fasting 5.6–7.0 or random 5.6–11.1 regulation. ≥ 7.0 11.1 diabetes. Perioperative ischaemia identified by 72‐h Holter...
Abstract Background The number of elderly patients with pancreatic cancer is growing, however clinical data on the short-term outcomes, rate adjuvant chemotherapy, and survival in these are limited we therefore performed a nationwide analysis. Methods Data from prospective Dutch Pancreatic Cancer Audit were analyzed, including all undergoing resection between January 2014 December 2016. Patients classified into two age groups: <75 ≥75 years. Major complications (Clavien–Dindo grade 3 or...
Objective To establish whether one can build a mortality prediction model for COVID-19 patients based solely on demographics and comorbidity data that outperforms age alone. Such could be precursor to implementing smart lockdowns vaccine distribution strategies. Methods The training cohort comprised 2337 inpatients from nine hospitals in Netherlands. clinical outcome was death within 21 days of being discharged. features were derived electronic health records collected during admission....
Chronic pain after cardiac surgery, whether or not related to the operation, is common and has negative impact on health quality of life (HRQL). Frailty a risk factor for adverse surgical outcomes, but its relationship with chronic surgery unknown. This study aimed address association between frailty following surgery.
Background Patients undergoing noncardiac, nonvascular surgery are at risk for perioperative mortality owing to underlying (a)symptomatic coronary artery disease. We hypothesized that β-blocker and statin use associated with reduced mortality. Methods performed a case–control study in 75 581 patients who underwent 108 593 the Erasmus Medical Center between 1991 2001. Cases were 989 died during hospital stay after surgery. From remaining patients, 1879 matched controls (age, sex, calendar...