A5078845255- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Function and Risk Factors
- Viral Infections and Immunology Research
- Infective Endocarditis Diagnosis and Management
- Organ Donation and Transplantation
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac and Coronary Surgery Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Fuel Cells and Related Materials
- Cerebrovascular and Carotid Artery Diseases
- Surgical Simulation and Training
- Lipoproteins and Cardiovascular Health
- Neonatal Respiratory Health Research
- Cancer Treatment and Pharmacology
- Health Promotion and Cardiovascular Prevention
- Cardiac Fibrosis and Remodeling
- Sepsis Diagnosis and Treatment
Utrecht University
2013-2025
University Medical Center Utrecht
2013-2025
SMART Reading
2024
Erasmus MC
2005-2024
Hypertension Institute
2024
Heidelberg University
2019-2023
University Hospital Heidelberg
2019-2023
Erasmus University Rotterdam
2005-2012
Purpose The Utrecht Cardiovascular Cohort–Second Manifestations of Arterial Disease (UCC-SMART) Study is an ongoing prospective single-centre cohort study with the aim to assess important determinants and prognosis cardiovascular disease progression. This article provides update rationale, design, included patients, measurements findings from start in 1996 date. Participants UCC-SMART includes patients aged 18–90 years referred University Medical Center Utrecht, Netherlands, for management...
Abstract Background and purpose Risk factors for stroke differ between women men in general populations. However, little is known about sex differences secondary prevention. We investigated if interacted with modifiable risk a large arterial disease cohort. Methods Within the prospective UCC-SMART study, 13,898 patients (35% women) atherosclerotic or high-risk factor profile were followed up to 23 years incidence recurrence. Hypertension, smoking, diabetes, overweight, dyslipidemia, high...
Abstract Aims The efficacy of a healthy lifestyle in secondary prevention cardiovascular disease (CVD) is well established and first-line recommendation CVD guidelines. aim this study was to assess whether Mediterranean diet physical activity are also cost-effective patients with CVD. Methods results A cost–utility analysis (CUA) performed comparing combined intervention usual care CUA had healthcare perspective lifetime horizon. Costs utilities were estimated using microsimulation on cohort...
Hypothermic oxygenated perfusion (HOPE) is a promising method for donor heart preservation, but the hypothermic conditions reduce metabolic activity, making cardiac evaluation challenging, and necessitating prognostic biomarkers to monitor graft quality. This study aims identify during HOPE that predict function. Seven porcine slaughterhouse hearts underwent 4 hours of followed by normothermic machine (NMP) with continuous functional assessment, including measurements output (CO), index...
Local recurrence and peritoneal dissemination is common after intentionally curative resection of colorectal carcinoma. It not yet clear which mechanisms stimulate post-operative intra-abdominal tumor development. Enhanced adhesion or growth cells and/or immuno suppression may influence recurrence.In the present study, we evaluated effects local remote surgery on development.A standardized trauma was inflicted by rubbing both uterus horns in laparotomy groups, while a dorsolateral...
Investigate associations of cognitive and brain reserve with trajectories memory decline in mid-life late-life, whether the relationship atrophy differs as a function reserve.
Minimally invasive mitral valve surgery (MIMVS) has been performed increasingly for the past 2 decades; however, large comparative studies on short- and long-term outcomes have lacking. This study aims to compare of patients undergoing MIMVS versus median sternotomy (MST) based real-world data, extracted from Netherlands Heart Registration.Patients surgery, with or without tricuspid valve, atrial septal closure and/or rhythm between 2013 2018 were included. Primary short-term morbidity...
Abstract Aims Left ventricular assist device therapy has become the cornerstone in treatment of end‐stage heart failure and is increasingly used as destination next to bridge transplant or recovery. HeartMate 3 (HM3) HeartWare (HVAD) are centrifugal continuous flow devices implanted intrapericardially most commonly worldwide. No randomized controlled trials have been performed yet. Analysis based on large registries may be considered best alternative but disadvantage different standard care...
Introduction To validate slaughterhouse hearts for ex-situ heart perfusion studies, we compared cold oxygenated machine in less expensive porcine ( N = 7) to that are harvested following the golden standard laboratory animals 6). Methods All received modified St Thomas 2 crystalloid cardioplegia prior 4 hours of perfusion. Hearts were perfused with homemade Steen solution a pressure 20–25 mmHg achieve coronary flow between 100–200 mL/min. Reperfusion and testing was performed on...
Abstract Background With more patients qualifying for heart transplantation (HT) and fewer hearts being transplanted, it is vital to look other options. To date, only organs from brain-dead donors have been used HT in the Netherlands. We investigated waiting list mortality all Dutch centres potential of donation after circulatory death (DCD) Methods Two different cohorts were evaluated. One cohort was defined as who newly listed or already on between January 2013 December 2017. Follow-up...
Identifying patients with established cardiovascular disease (CVD) who are at high risk of type 2 diabetes (T2D) may allow for early interventions, reducing the development T2D and associated morbidity. The aim this study was to develop externally validate CVD2DM model estimate 10-year lifetime risks in CVD. Sex-specific, competing risk-adjusted Cox proportional hazard models were derived 19 281 participants CVD without baseline from UK Biobank. core model's pre-specified predictors age,...