A5085869839- Cerebrovascular and Carotid Artery Diseases
- Health disparities and outcomes
- Bipolar Disorder and Treatment
- Acute Ischemic Stroke Management
- Birth, Development, and Health
- Cardiovascular Health and Disease Prevention
- Pregnancy and preeclampsia studies
- Schizophrenia research and treatment
- Global Health Care Issues
- Health, Environment, Cognitive Aging
- Mental Health Treatment and Access
- Nutritional Studies and Diet
- Cardiovascular Health and Risk Factors
- Air Quality and Health Impacts
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Moyamoya disease diagnosis and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Advanced Neuroimaging Techniques and Applications
- Suicide and Self-Harm Studies
- Smoking Behavior and Cessation
- Advanced MRI Techniques and Applications
- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Electroconvulsive Therapy Studies
University Medical Center Utrecht
2019-2025
Oulu University Hospital
2014-2024
Amsterdam University Medical Centers
2024
University of Amsterdam
2024
University of Oulu
2012-2024
Utrecht University
2019-2024
Amsterdam University of Applied Sciences
2024
Oklahoma State University Center for Health Sciences
2022
Abstract Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether interact with or modify the effects of health behaviors, such as smoking alcohol use, relation incidence. Two‐stage individual participant data meta‐analyses were performed based on 22 cohorts PSYchosocial CAncer (PSY‐CA) study. nine (depression diagnosis, depression symptoms, perceived social support, loss events, general distress, neuroticism, relationship...
Abstract Background and purpose Risk factors for stroke differ between women men in general populations. However, little is known about sex differences secondary prevention. We investigated if interacted with modifiable risk a large arterial disease cohort. Methods Within the prospective UCC-SMART study, 13,898 patients (35% women) atherosclerotic or high-risk factor profile were followed up to 23 years incidence recurrence. Hypertension, smoking, diabetes, overweight, dyslipidemia, high...
BACKGROUND: Risk factors for cerebrovascular disease in adulthood are well known. However, research on individuals’ risk throughout their life span has been limited. This prospective cohort study aims to determine the effect of body mass index (BMI) and its changes adolescence young early onset disease. METHODS: includes 10 491 people (5185 women) from Northern Finland Birth Cohort 1966. Height, weight, BMI were measured at ages 14 31 years. Sex- age-specific ranges used define overweight...
Objectives Aneurysmal subarachnoid haemorrhage (ASAH) is a severe stroke type, preventable by screening for intracranial aneurysms followed treatment in high-risk individuals. We aimed to develop and validate risk prediction model ASAH the general population identify Design used population-based prospective cohort studies of United Kingdom (UK) Biobank development Trøndelag Health (HUNT) Study validation. Participants missing data were excluded. A total 456 856 individuals from UK 46 483...
Abstract Objectives Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) test whether psychosocial (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with incidence any cancer (any, breast, lung, prostate, colorectal, smoking‐related, alcohol‐related); (2) interaction between related (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep,...
Abstract Smoking remains among the leading causes of mortality worldwide. Obtaining a comprehensive understanding population’s smoking behaviour is essential for tobacco control. Here, we aim to characterize lifelong patterns and explore underlying sociodemographic lifestyle factors in population-based birth cohort population followed up 46 years. Our analysis based on 5797 individuals from Northern Finland Birth Cohort 1966 who self-reported their at ages 14, 31 46. Data sex, education,...
Abstract Background Productivity costs result from loss of paid and unpaid work replacements due to morbidity mortality. They are usually assessed in health economic evaluations with human capital method (HCM) or friction cost (FCM). The methodology for estimating lost productivity is an area considerable debate. Objective To compare traditional adjusted HCM FCM estimates among young stroke patients. Methods Northern Finland Birth Cohort 1966 was followed until the age 50 identify all 339...
Asymptomatic low-grade carotid artery stenosis (LGCS) is a common finding in patients with manifest arterial disease, however its relationship brain MRI changes and cognitive decline unclear. We included 902 (58 ± 10 years; 81% male) enrolled the Second Manifestations of Arterial Disease – Magnetic Resonance (SMART-MR) study without history cerebrovascular disease. LGCS was defined as 1–49% on baseline ultrasound, whereas no (reference category) absence plaque. Brain white matter...
Psychotic disorders are associated with substantial productivity costs; however no previous studies have compared these between schizophrenia spectrum (SSD) and other psychotic (OP). The human capital method (HCM) the friction cost (FCM) two most common approaches to assess costs. HCM focuses on employees' perspectives costs, whereas FCM demonstrates employers' perspectives. Studies comparing methods when estimating costs of psychoses lacking.
In addition to psychoses, antipsychotic drugs are nowadays also prescribed for other psychiatric disturbances, such as mood disorders. We wanted find out whether there is any association between the use of and suicidality in cases psychotic non‐psychotic Our sample was population‐based Northern Finland 1966 Birth Cohort. Information on collected 1997 from nationwide medication register with a postal questionnaire ( N = 8218). The presence suicidal ideation assessed cross‐sectionally using...
Background Smoking is a well-known risk factor for stroke. However, the relationship between smoking trajectories during life course and stroke not known. Aims We aimed to study association of smoked pack-years with ischemic haemorrhagic strokes in population-based birth cohort followed up 50 years age. Methods Within Northern Finland Birth Cohort 1966, 11,999 persons were from antenatal period age years. The behaviour was assessed postal questionnaires at ages 14, 31 46 Stroke diagnoses...
We determined the occurrence and association of cortical cerebral microinfarcts (CMIs) at 7 T MRI with risk factors, neuroimaging markers small large vessel disease, cognitive functioning. Within Medea-7T study, a diverse cohort older persons normal cognition, patients vascular memory clinic patients, we included 386 participants (68 ± 9 years) available 1.5 T/3T brain MRI, factor neuropsychological data. CMIs were found in 10% associated age (RR = 1.79 per +10 years, 95%CI 1.28-2.50),...
Background: Low birth weight is associated with an increased risk of adulthood cerebrovascular disease (CVD). Not much known about effects early childhood growth. We studied whether the adult CVD growth or nutritional factors during childhood. Methods: Within Northern Finland Birth Cohort 1966, 11 991 persons were followed from to 52 years age. diagnoses extracted national hospital and death registers diagnostic coding based on World Health Organization recommendations. Cox proportional...
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Objective The aim was to study the association between use of antidepressant medication and suicidal ideation in different diagnostic groups a large population‐based cohort. Methods Information on prescribed drugs within Northern Finland Birth Cohort 1966 collected at age 31 years with postal questionnaire ( N = 8218). presence assessed via Hopkins Symptom Checklist‐25 questionnaire. We studied associations various symptom groups, it adjusted for symptoms depression anxiety. Results Suicidal...
<h3>BACKGROUND AND PURPOSE:</h3> The clinical relevance of cortical microinfarcts has recently been established; however, studies on in the deep gray matter are lacking. We examined risk factors and MR imaging correlates 7T their relation to cognitive functioning. <h3>MATERIALS METHODS:</h3> Within Second Manifestations ARTerial disease–Magnetic Resonance (SMART-MR) study, 213 patients (mean age, 68 [SD, 8] years) had a risk-factor assessment, 1.5T brain imaging, examination. Microinfarcts...
Background and purpose Arterial calcifications on unenhanced CT scans vessel wall lesions MRI are often used interchangeably to portray intracranial arterial disease. However, the extent of pathology depicted with each technique is unclear. We investigated presence distribution these two imaging findings in patients a history cerebrovascular Materials methods analyzed data from 78 admitted for stroke or TIA at our institution. Vessel were assessed 7 T sequences, while scans. The number...
The incidence of cerebrovascular disease (CVD) is rising among young adults (< 55 years). risk for CVD starts to form in early childhood and comprised genetic environmental factors. aim this study investigate the relationship between family socioeconomic status (SES), inherited risk, until midlife. In Northern Finland Birth Cohort 1966 12,058 children, individuals were followed from gestational period up 54 years. We used previously published SES clusters, based on latent class analysis a...