A5064932904- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Alzheimer's disease research and treatments
- Language Development and Disorders
- Aging and Gerontology Research
- Health disparities and outcomes
- Action Observation and Synchronization
- Reading and Literacy Development
- Speech Recognition and Synthesis
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Phonetics and Phonology Research
- Cerebrovascular and Carotid Artery Diseases
- Cognitive Functions and Memory
- Frailty in Older Adults
- Identity, Memory, and Therapy
- Cardiovascular Health and Disease Prevention
- Voice and Speech Disorders
- Blood Pressure and Hypertension Studies
- Stuttering Research and Treatment
- Chronic Disease Management Strategies
- Stroke Rehabilitation and Recovery
- Nutritional Studies and Diet
- Language, Metaphor, and Cognition
- Categorization, perception, and language
University Memory and Aging Center
2019-2025
University of California, San Francisco
2019-2025
University Medical Center Utrecht
2019-2024
Utrecht University
2020-2024
Columbia University Irving Medical Center
2018-2023
Google (United States)
2023
Columbia University
2018-2022
Oklahoma State University Center for Health Sciences
2020-2021
Universidade Federal de Minas Gerais
2021
Vrije Universiteit Amsterdam
2021
Abstract Sex or gender differences in the risk of Alzheimer's disease and related dementias (ADRD) differ by world region, suggesting that there are potentially modifiable factors for intervention. However, few epidemiological clinical ADRD studies examine sex differences; even fewer evaluate context risk. The goals this perspective to: (1) provide definitions gender, biologic sex, sexual orientation. limitations examining these as binary variables; (2) an overview what is known with regard...
We examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity.
To investigate whether illiteracy was associated with greater risk of prevalent and incident dementia more rapid cognitive decline among older adults low education.Analyses included 983 (≥65 years old, ≤4 schooling) who participated in a longitudinal community aging study. Literacy self-reported ("Did you ever learn to read or write?"). Neuropsychological measures memory, language, visuospatial abilities were administered at baseline follow-ups (median [range] 3.49 [0-23]). At each visit,...
In the last decade, Alzheimer's disease research has seen large shifts, particularly regarding diagnostic criteria and use of protein biomarkers. The Association (AA) workgroup recently revised their previous 2018 (Jack Jr et al., 2018) for diagnosis staging to now inform both clinical care 2024a), maintaining a biological definition that primarily relies upon biomarkers, such as amyloid tau levels, identify even in absence cognitive symptoms (e.g. memory language impairment)....
Verbal fluency tasks are generally thought to be mediated by frontal brain regions for letter and temporal category fluency. This idea, however, is primarily based on lesion studies adapted versions of the in functional neuroimaging, without fundamental evidence from structural neuroimaging healthy individuals. We investigated cortical correlates fluency, including overlapping different regions, 505 individuals who participated a community-based study aging. The correlation between thickness...
Objective The purpose of this study was to evaluate the measurement invariance a neuropsychological battery across race/ethnicity by sex/gender subgroups over repeated measurements. Method Participants were 6,057 non-Hispanic White (NHW), Black, and Hispanic men women in Washington/Hamilton Heights Inwood Columbia Aging Project (WHICAP) who administered tests memory, language, visuospatial abilities at 18 24-month intervals for up 25 years. Invariance analyses conducted on three-factor model...
Exposure to socioeconomic disadvantage is associated with early-onset cognitive aging. Biological aging, the progressive loss of system integrity that occurs as we age, proposed a modifiable process mediating this health inequality. We examined whether disparities in aging mid-to late-life adults explained by accelerated biological similarly across race, ethnicity, and sex/gender.
Abstract Introduction The present study sought to determine whether cognitive trajectories differ between men and women across within racial/ethnic groups. Methods Participants were 5258 non‐Hispanic White (NHW), Black, Hispanic in the Washington/Hamilton Heights‐Inwood Columbia Aging Project who administered neuropsychological tests of memory, language, visuospatial abilities at 18‐ 24‐month intervals for up 25 years. Multiple‐group latent growth curve modeling examined sex/gender by...
Objective To assess progression of semantic loss in early stages cognitive decline using and letter fluency performance, its relation with Alzheimer's disease (AD)-specific neurodegeneration longitudinal multimodal neuroimaging measures. Methods Change verbal was analyzed among 2261 non-demented individuals a follow-up diagnosis no mild impairment (MCI), amnestic MCI (aMCI), non-amnestic (naMCI), or incident dementia, linear mixed models across 4 years follow-up, relations magnetic resonance...
To investigate sociodemographic and medical predictors of incident mild cognitive impairment (MCI) subsequent course MCI at follow-up, including sustained diagnosis, classification as cognitively normal, progression to dementia.
Background As global populations age, cross-national comparisons of cognitive health and dementia risk are increasingly valuable. It remains unclear, however, whether country-level differences in function attributable to population or bias due incommensurate measurement. To demonstrate an effective method for comparison studies, we aimed statistically harmonize measures episodic memory language across two population-based cohorts older adults the United States (HRS HCAP) India (LASI-DAD)....
Aggregation of cohort data increases precision for studying neurodegenerative disease pathways, but efforts to combine and expertise are often hampered by infrastructural, ethical legal considerations. We aimed unite various studies in the Netherlands enhance research infrastructure facilitate on dementia etiology its public health implications. The Consortium Dementia Cohorts (NCDC) includes participants with initially no established cognitive impairment from 9 Dutch cohorts: Amsterdam...
Cognitive impairment is common in patients with heart failure, but to which extent cognitive complaints are evaluated and listed clinical practice unknown. Therefore, this study aims identify whether notes of consistent attending memory clinics, by using natural language processing (NLP) techniques. Patients failure a outpatient clinic were identified echocardiography reports presence codes stored the Utrecht Individual-Oriented Database (UPOD) from 2011 2023. Named Entity Detection Linking...
Background: Cognitive change is an important factor in understanding dementia. Estimating effects of exposures on cognitive requires choosing analytical timescale, typically time study or current age. There limited consensus regarding timescale choice epidemiologic aging research. Methods: Using a coordinated analytic approach ten cohorts older adults, we evaluated whether estimated two memory differed depending (time age). We modeled APOE ε4 genotype (a time-invariant exposure) and diabetes...
Frontotemporal dementia (FTD) includes behavioral-variant FTD (bvFTD) with predominant frontal atrophy and semantic (sbvFTD) right anterior temporal lobe (rATL) atrophy. These variants present diagnostic challenges because of overlapping symptoms neuroanatomy. Accurate differentiation is crucial for clinical trial inclusion targeting TDP-43 proteinopathies. This study investigated whether automated speech analysis can distinguish between FTD-related rATL atrophy, potentially offering a...
This prospective study seeks to examine the utility of subjective cognitive decline (SCD) as a marker future progression dementia in community-based cohort non-Latinx White, Black, and Latinx individuals. Debate surrounds SCD, perception one's cognition before such impairment is evident traditional neuropsychological assessments, an early indicator impending Alzheimer disease. Unfortunately, most studies examining SCD have been conducted White samples commonly exclude groups individuals...
OBJECTIVE Accurate identification of the earliest cognitive changes associated with Alzheimer's disease (AD) is critically needed. Item-level information within tests category fluency, such as lexical frequency, harbors valuable about integrity semantic networks affected early in AD. To determine potential frequency a marker AD risk, we investigated whether animal fluency output differentiated APOE e4 carriers from noncarriers cross-sectional design among older African-American adults...
Abstract Introduction This study aimed to determine if later birth year influences trajectory of age‐related cognitive decline across racial/ethnic groups and test whether years school, childhood socioeconomic status, cardiovascular disease burden explain such secular trends. Methods We compared trajectories global cognition subdomains in two successive racially/ethnically educationally diverse cohorts a prospective cohort study. Results Later was associated with higher initial levels for...
Investigate associations of cognitive and brain reserve with trajectories memory decline in mid-life late-life, whether the relationship atrophy differs as a function reserve.
Frontotemporal dementia (FTD) is an early-onset neurodegenerative disorder with a heterogeneous clinical presentation. Verbal fluency regularly used as sensitive measure of language ability, semantic memory, and executive functioning, but qualitative changes in verbal FTD are currently overlooked. This retrospective study examined qualitative, linguistic features 137 patients behavioral variant (bv)FTD (