A5087377793- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Risk Factors
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Cardiac Health and Mental Health
- Diabetes Treatment and Management
- Heart Rate Variability and Autonomic Control
- Retinal Imaging and Analysis
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Health disparities and outcomes
- Cardiovascular and exercise physiology
- Retinal Diseases and Treatments
- Stroke Rehabilitation and Recovery
- Thermoregulation and physiological responses
- Chronic Disease Management Strategies
University Medical Center Utrecht
2022-2025
Maastricht University Medical Centre
2015-2024
Maastricht University
2015-2024
Cardiovascular Institute Hospital
2020-2024
Utrecht University
2023-2024
Heidelberg University
2023-2024
University Hospital Heidelberg
2023-2024
Université Paris Cité
2018-2023
Inserm
2018-2023
Paris Cardiovascular Research Center
2018-2023
<h3>Importance</h3> Trends in type 2 diabetes show an increase prevalence along with younger age of onset. While vascular complications early-onset are known, the associations dementia remains unclear. <h3>Objective</h3> To determine whether at onset is more strongly associated incidence dementia. <h3>Design, Setting, and Participants</h3> Population-based study UK, Whitehall II prospective cohort study, established 1985-1988, clinical examinations 1991-1993, 1997-1999, 2002-2004, 2007-2009,...
Objective: The vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms by disruption of brain structures involved in mood regulation. However, longitudinal data on the association between CSVD and are scarce. authors investigated incident symptoms. Method: Longitudinal were taken from Age, Gene/Environment Susceptibility-Reykjavik Study 1,949 participants free dementia without baseline (mean age: 74.6 years [SD=4.6]; women, 56.6%). MRI...
Greater very short- to midterm blood pressure variability (BPV) has been associated with an increased cardiovascular disease risk, especially stroke. However, this link remains incompletely understood. We hypothesized that arterial stiffness and maladaptive carotid remodeling may underlie association. We, therefore, investigated the association between systolic BPV, aortic using cross-sectional data from The Maastricht Study (aged 60±8 years; 53% men). Aortic (carotid-femoral pulse wave...
Abstract Insomnia symptoms are highly prevalent and associated with several adverse medical conditions, but only few determinants, including non-modifiable ones, have been highlighted. We investigated associations between body silhouette trajectories over the lifespan insomnia in adulthood. From a community-based study, 7 496 men women aged 50–75 years recalled their at age 8, 15, 25, 35 45, rated frequency of on standardized sleep questionnaire. An Epworth Sleepiness Scale ≥11 defined...
In the pathogenesis of cardiovascular events, interaction between risk factors has seldom been identified. However, endothelial dysfunction on one hand and type 2 diabetes mellitus, impaired glucose metabolism (IGM), insulin resistance other may act synergistically (ie, interact) in development disease. We therefore investigated IGM, with regard to events. a prospective population-based cohort (n=445; 69 years; 55% women; 23% 28% IGM [by design]), (brachial artery flow-mediated dilatation),...
Background Endothelial dysfunction (ED), low-grade inflammation (LGI) and oxidative stress (OxS) may be involved in the pathobiology of depression. Previous studies on association these processes depression have yielded contradictory results. We therefore investigated comprehensively, a population-based cohort study, between ED, LGI OxS one hand depressive symptoms other. Method used data from Hoorn Study determined biomarkers ED [flow-mediated dilatation (FMD), von Willebrand factor,...
Microvascular dysfunction may be associated with worse cognitive performance. Most previous studies did not adjust for important confounders, evaluated only individual measures of microvascular dysfunction, and showed inconsistent results. We the association between a comprehensive set performance in population-based Maastricht Study. used cross-sectional data including 3011 participants (age 59.5±8.2; 48.9% women; 26.5% type 2 diabetes mellitus [oversampled by design]). Measures included...
<h3>Importance</h3> There is consistent evidence of the association between ideal cardiovascular health and lower incident disease (CVD); however, most studies used a single measure health. <h3>Objective</h3> To examine how changes over time whether these are associated with CVD. <h3>Design, Setting, Participants</h3> Prospective cohort study in UK general community (Whitehall II), examinations from 1985/1988 (baseline) every 5 years thereafter until 2015/2016 follow-up for CVD March 2017....
Arterial stiffness may contribute to depression via cerebral microvascular damage, but evidence for this is scarce. We therefore investigated whether arterial associated with depressive symptoms and small vessel disease contributes association.This cross-sectional study included a subset of participants from the AGES-Reykjavik second examination round, which was conducted 2007 2011. (carotid-femoral pulse wave velocity [CFPWV]), (15-item geriatric scale [GDS-15]) (MRI) were determined....
Arterial stiffening, as characterized by an increase in carotid–femoral pulse-wave velocity or pulse pressure, increases the risk of cardiovascular disease, especially among individuals with type 2 diabetes mellitus. Advanced glycation end products are hypothesized to play a role development arterial stiffness. Therefore, we investigated association between skin autofluorescence, estimate tissue advanced products, and plasma on one hand stiffening other 862 participants The Maastricht Study...
Carotid arterial diameter enlargement is a manifestation of remodeling and may be risk factor for cardiovascular disease (CVD). We evaluated the association between carotid artery stroke, coronary heart disease, CVD, all-cause mortality explored whether associations could explained by processes involved in remodeling, that is, blood pressure-related media thickening, stiffness, wall stress, atherosclerosis. included 4887 participants (mean age 67±9 years; 54% women) from 4 cohort studies:...
Background Lesions of cerebral small vessel disease, such as white matter hyperintensities (WMHs) in individuals with cardiometabolic risk factors, interfere the trajectories and eventually contribute to cognitive decline. However, there is no consensus yet about precise underlying topological mechanism. Purpose To examine whether WMH function are associated any association mediated or explained by structural connectivity measures an adult population. In addition, investigate local...