A5061757410- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Thermoregulation and physiological responses
- Cardiovascular and exercise physiology
- Cerebrovascular and Carotid Artery Diseases
- Nutritional Studies and Diet
- Physical Activity and Health
- Retinal Imaging and Analysis
- Cardiac Health and Mental Health
- Heart rate and cardiovascular health
- Dementia and Cognitive Impairment Research
- Nosocomial Infections in ICU
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mechanical Circulatory Support Devices
- Cardiovascular Syncope and Autonomic Disorders
- Infections and bacterial resistance
- Sodium Intake and Health
Maastricht University
2017-2022
Maastricht University Medical Centre
2016-2022
University Medical Center
2022
Zuyderland Medisch Centrum
2021
Cardiovascular Institute Hospital
2017-2020
Geneeskundige en Gezondheidsdienst
2020
Sorbonne Paris Cité
2018
Université Paris Cité
2018
Délégation Paris 5
2018
Paris Cardiovascular Research Center
2018
Greater very short- to midterm blood pressure variability (BPV) has been associated with an increased cardiovascular disease risk, especially stroke. However, this link remains incompletely understood. We hypothesized that arterial stiffness and maladaptive carotid remodeling may underlie association. We, therefore, investigated the association between systolic BPV, aortic using cross-sectional data from The Maastricht Study (aged 60±8 years; 53% men). Aortic (carotid-femoral pulse wave...
OBJECTIVE Low heart rate variability (HRV), a marker for cardiac autonomic dysfunction, is known feature of type 2 diabetes, but it remains incompletely understood whether this also applies to prediabetes or across the whole glycemic spectrum. Therefore, we investigated association among prediabetes, and measures glycemia HRV. RESEARCH DESIGN AND METHODS In population-based Maastricht Study (n = 2,107; mean ± SD age 59 8 years; 52% men; normal glucose metabolism [n 1,226], 331], diabetes...
An increasing number of individuals will face age-related cognitive difficulties because life expectancy has increased. It is, therefore, important to identify modifiable risk factors for impairment. Very short–term mid-term blood pressure variability (BPV) may be such a factor it cause cerebral ischemia. To this end, we investigated whether greater systolic and diastolic BPV are cross-sectionally associated with memory function (n=1804), information processing speed (n=1793), executive...
The mechanisms associating (pre)diabetes and cardiovascular disease (CVD) are incompletely understood. We hypothesize that greater blood pressure variability (BPV) may underlie this association, due to its association with (incident) CVD. Therefore, we investigated the between very short-term mid-term BPV, is within-visit, 24-h 7-day BPV.Cross-sectional data from Maastricht Study [normal glucose metabolism (NGM), n = 1924; prediabetes, 511; type 2 diabetes mellitus (T2DM), 975; 51% men, aged...
Stenotrophomonas maltophilia is increasingly identified in critically ill patients, but it considered a pathogen with limited pathogenicity and therefore infrequently targeted. This study explores whether S. may cause ventilator-associated pneumonia (VAP) affects intensive care unit (ICU) mortality 28-day when compared to VAP caused by other Gram-negative bacilli.Retrospective analysis of 19-year prospectively collected database. as was VAP-suspected cases growth ≥10(4) cfu/ml detected...
Microvascular dysfunction (MVD) contributes to stroke, dementia, depression, retinopathy and chronic kidney disease. However, the determinants of MVD are incompletely understood. Greater blood pressure variability (BPV) may be one such determinant.We used cross-sectional data The Maastricht Study (n = 2773, age 59.9 years; 51.9% men) investigate whether greater very short- mid-term BPV is associated with various measures. We standardized averaged within-visit, 24-h 7-day into a systolic...
Low baroreflex sensitivity (BRS) has been hypothesized to underlie high blood pressure (BP) and greater BP variability on the longer term, but evidence is scarce. In addition, these associations may differ by sex (pre)diabetes. Therefore, we investigated whether cardiovagal BRS associated with short- mid-term mean variability, differs according (pre)diabetes.Cross-sectional data from population-based Maastricht study (age 60 ± 8 years, 52% men), where office ( n = 2846), 24-h 2404) 7-day...
Abstract Objective This study investigated whether arterial stiffening is a determinant of subtle retinal microvascular changes that precede diabetic retinopathy. Research design and methods used cross‐sectional data from the Maastricht Study, type 2 diabetes‐enriched population‐based cohort study. We multivariable linear regression analysis to investigate, in individuals without with diabetes, associations carotid distensibility coefficient carotid‐femoral pulse wave velocity diameters...
Background Salt restriction may lower blood pressure variability (BPV), but previous studies have shown inconsistent results. Therefore, we investigated in an observational study and intervention trial whether urinary sodium excretion salt intake are associated with 24-hour BPV. Methods Results We used data from the cross-sectional population-based Maastricht Study (n=2652; 60±8 years; 52% men) a randomized crossover (n=40; 49±11 33% men). In study, measured BPV performed linear regression...
Objective : An exaggerated exercise SBP, which is potentially modifiable, may be associated with incident depressive symptoms via an increased pulsatile pressure load on the brain. However, association between SBP and unknown. Therefore, we examined whether a higher risk of over time. Methods We used longitudinal data from population-based Maastricht Study, only individuals free at baseline included ( n = 2121; 51.3% men; age 59.5 ± 8.5 years). Exercise was measured submaximal cycle test....
Objective: The mechanisms underlying the associations between (pre)diabetes and cardiovascular disease (CVD) are incompletely understood. We hypothesize that greater blood pressure variability (BPV) may underlie this association, as BPV is associated with (incident) CVD. However, data on in scarce. Therefore, we investigated association within-visit, 24-hour 7-day BPV. Design method: Cross-sectional from Maastricht Study (N = 3451, 1924 normal glucose metabolism [NGM], 511 prediabetes, 975...
Abstract Background Exaggerated exercise systolic blood pressure (SBP) is a modifiable risk factor associated with vascular dysfunction. Vascular dysfunction may contribute to the development of late-life depression, but association between SBP and incident depressive symptoms unknown. Therefore, we investigated whether an exaggerated higher over time. Methods Longitudinal data from population-based Maastricht Study, only individuals free at baseline included ( n = 2,121; 51.3% men; age 59.5...
Exercise blood pressure (BP), both high and low responses, is associated with the development of cardiovascular disease all-cause mortality. However, it unclear whether microvascular dysfunction a determinant exercise BP. Therefore, we investigated was (nonlinearly) BP.In population-based Maastricht Study (n = 1,688; age 59 ± 8 years; 51% men), generalised constructed by composite score features cerebral small vessel disease, retinal features, albuminuria, heat-induced skin hyperaemia plasma...