A5002081827- Bone health and osteoporosis research
- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Hip and Femur Fractures
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular Disease and Adiposity
- Nutrition and Health in Aging
- Advanced Neuroimaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Neurological Disease Mechanisms and Treatments
- Hip disorders and treatments
- Bone and Joint Diseases
- Cardiovascular Function and Risk Factors
- Genetic Associations and Epidemiology
- Body Composition Measurement Techniques
- Behavioral and Psychological Studies
- Nutritional Studies and Diet
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Health, Environment, Cognitive Aging
- Advanced MRI Techniques and Applications
- Occupational Health and Safety Research
- Blood Pressure and Hypertension Studies
- Orthopaedic implants and arthroplasty
Icelandic Heart Association
2016-2025
University of Iceland
2013-2025
National Institute on Aging
2009-2024
Leiden University Medical Center
2009-2024
Rigshospitalet
2023
Reykjavík University
2010-2022
Erasmus MC
2020
Brown Foundation
2015-2020
Alzheimer’s Disease Neuroimaging Initiative
2020
University of Maryland, Baltimore County
2006-2019
Aortic stiffness increases with age and vascular risk factor exposure is associated increased for structural functional abnormalities in the brain. High ambient flow low impedance are thought to sensitize cerebral microcirculation harmful effects of excessive pressure pulsatility. However, haemodynamic mechanisms contributing brain lesions cognitive impairment presence high aortic remain unclear. We hypothesized that disproportionate stiffening proximal aorta as compared carotid arteries...
The blood proteome in disease Understanding the function of human serum proteins has been limited by difficulties monitoring their production, accumulation, and distribution. Emilsson et al. investigated more than 5000 Icelanders over age 65. composition includes a complex regulatory network that are globally coordinated across most or all tissues. authors identified modules functional groups associated with health outcomes were able to link genetic variants diseases. Science , this issue p. 769
<h3>Importance</h3> Interstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total capacity. However, to our knowledge, an association mortality has not previously investigated. <h3>Objective</h3> To investigate whether interstitial are increased mortality. <h3>Design, Setting, Population</h3> Prospective cohort studies of 2633 participants from the FHS (Framingham Heart Study; computed tomographic [CT] scans obtained...
Unrecognized myocardial infarction (MI) is prognostically important. Electrocardiography (ECG) has limited sensitivity for detecting unrecognized MI (UMI).Determine prevalence and mortality risk UMI detected by cardiac magnetic resonance (CMR) imaging or ECG among older individuals.ICELAND a cohort substudy of the Age, Gene/Environment Susceptibility-Reykjavik Study (enrollment January 2004-January 2007) using CMR to detect UMI. From community-dwelling individuals in Iceland, data 936...
ABSTRACT Finite element analysis of computed tomography (CT) scans provides noninvasive estimates bone strength at the spine and hip. To further validate such clinically, we performed a 5-year case-control study 1110 women men over age 65 years from AGES-Reykjavik cohort (case = incident or hip fracture; control no fracture). From baseline CT scans, measured femoral vertebral strength, as well mineral density (BMD) (areal BMD only) lumbar (trabecular volumetric only). We found that for...
Bone marrow fat (BMF) and bone mineral density (BMD) by dual x-ray energy absorptiometry (DXA) are negatively correlated. However, little is known about the association of BMF with fracture or separate trabecular cortical compartments. Our objective was to assess relationships between vertebral BMF, BMD quantitative computed tomography, in older adults. We conducted a cross-sectional study Age Gene/Environment Susceptibility-Reykjavik cohort. Outcomes measures included (L1–L4) measured...
<h3>Background and purpose:</h3> Incidental foci of signal loss suggestive cerebral microbleeds (CMBs) are frequent findings on gradient echo T2* weighted MRI (T2* MRI) patients with haemorrhagic or ischaemic stroke. There few prevalence data older populations. This paper reports the location CMBs in a community based cohort men women (born 1907–1935) who participated Age Gene/Environment Susceptibility (AGES)-Reykjavik Study, population study that followed Reykjavik Study <h3>Methods:</h3>...
To determine whether microvascular damage, indicated by cerebral microbleeds (CMBs) and retinal signs, is associated with cognitive function dementia in older persons.This a cross-sectional study of 3,906 participants (mean age 76 years; 58% women) the AGES-Reykjavik Study (2002-2006). We assessed CMBs on MRI signs digital images. Composite Z scores memory, processing speed, executive were derived from battery neurocognitive tests. Dementia subtypes diagnosed following international...
With advancing age, an increased visibility of perivascular spaces (PVSs) on magnetic resonance imaging (MRI) is hypothesized to represent impaired drainage interstitial fluid from the brain and may reflect underlying cerebral small vessel disease (SVD). However, whether large (L-PVSs) (>3 mm in diameter) visible MRI are associated with SVD cognitive deterioration older individuals unknown.To examine L-PVSs progression established markers SVD, decline, risk dementia.The prospective,...
Background— The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings incompletely characterized. To identify novel variants influencing burden, we conducted a meta-analysis multiethnic genome-wide association studies. Methods Results— We included 21 079 middle-aged to elderly individuals from 29 population-based cohorts, who were free dementia stroke European (n=17...
Background: the prevalence of sarcopenia increases with age. Physical activity might slow rate muscle loss and therewith incidence sarcopenia. Objective: to examine association physical incident over a 5-year period. Design: data from population-based Age, Gene/Environment, Susceptibility–Reykjavik Study were used. Setting: people residing in Reykjavik area at start study. Subjects: study included aged 66–93 years (n = 2309). Methods: amount moderate–vigorous (MVPA) was assessed by...
Atrial fibrillation (AF) has been associated with cognitive decline independent of stroke, suggesting additional effects AF on the brain. We aimed to assess association between and brain function structure in a general elderly population.This is cross-sectional analysis 4251 nondemented participants (mean age, 76 ± 5 years) population-based Age, Gene/Environment Susceptibility-Reykjavik Study. Medical record data were collected for presence, subtype, time from first diagnosis AF; 330 had AF....
Cerebral infarcts increase the risk for cognitive impairment. The relevance of location and number with respect to function is less clear.We studied cross-sectional association between performance in 4030 nondemented participants Age Gene/Environment Susceptibility-Reykjavik Study. Composite scores memory, processing speed, executive were created from a neuropsychological battery. Subcortical, cortical, cerebellar identified on brain MRI. We performed linear regression analyses adjusted...
To assess the association of number and anatomic location cerebral microbleeds (CMBs), visible indicators microvascular damage on MRI, with incident cognitive disease in general population older people.In longitudinal population-based Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, 2,602 participants 66 to 93 years age free prevalent dementia underwent brain MRI testing verbal memory, processing speed, executive function at baseline a mean 5.2 later. Adjudicated cases were...
Objective: The vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms by disruption of brain structures involved in mood regulation. However, longitudinal data on the association between CSVD and are scarce. authors investigated incident symptoms. Method: Longitudinal were taken from Age, Gene/Environment Susceptibility-Reykjavik Study 1,949 participants free dementia without baseline (mean age: 74.6 years [SD=4.6]; women, 56.6%). MRI...
Atrial fibrillation (AF) has been associated with cognitive impairment. Additionally, brain volume may be reduced in individuals AF. Potential causes include cerebral micro-embolism or stroke due to the beat-to-beat variation The aims of this study were measure blood flow and estimate whole perfusion elderly without Blood cervical arteries was measured phase contrast MRI estimated a large cohort from AGES-Reykjavik Study. Individuals divided into three groups at time MRI: persistent AF,...