Ulla Sovio
A5034333560- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Genetic Associations and Epidemiology
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Obesity and Health Practices
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Growth Hormone and Insulin-like Growth Factors
- BRCA gene mutations in cancer
- Pancreatic function and diabetes
- Preterm Birth and Chorioamnionitis
- Global Cancer Incidence and Screening
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- Health, Environment, Cognitive Aging
- Diet, Metabolism, and Disease
- Eating Disorders and Behaviors
- Hypothalamic control of reproductive hormones
University of Cambridge
2015-2024
Imperial College London
2008-2024
Rosie Hospital
2015-2024
NIHR Cambridge Biomedical Research Centre
2018-2023
National Institute for Health Research
2015-2023
Health and Human Development (2HD) Research Network
2008-2023
National University of Singapore
2023
Transnational Press London
2021
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2019
RELX Group (United States)
2018
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetesâsusceptibility genes identified variant in FTO (fat mass and associated) gene predisposes diabetes through an effect on body index (BMI). An additive association with BMI was replicated 13 cohorts 38,759 participants. 16% adults who homozygous allele weighed about 3 kilograms more...
A bstract : Allergen‐induced secretion of Th2‐type cytokines and IgE production have recently been reported to be increased in mice treated with 1,25(OH) 2 D, the active form vitamin D. Our objective was investigate whether D supplementation infancy is associated risk atopy, allergic rhinitis, asthma. The Northern Finland Birth Cohort consists all individuals two most northern provinces who were due born 1966. Data on during first year life obtained 1967. Current asthma rhinitis at age 31...
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans largely unknown, despite its clinical and societal importance. We report genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol (gram per day kilogram body weight) among 12 population-based samples European ancestry, comprising 26,316 individuals, replication genotyping an additional 21,185 individuals. SNP rs6943555 autism susceptibility candidate 2 gene...
OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, high blood pressure, with an increased risk type 2 diabetes cardiovascular disease. This study tests whether common genetic variants pleiotropic effects account for some the correlated architecture among five phenotypes that define MetS. RESEARCH DESIGN AND METHODS Seven studies STAMPEED consortium, comprising 22,161 participants European ancestry, underwent...
OBJECTIVE To determine whether fetal overgrowth precedes the diagnosis of gestational diabetes mellitus (GDM) and to quantify interrelationships among overgrowth, GDM, maternal obesity. RESEARCH DESIGN AND METHODS We conducted a prospective cohort study unselected nulliparous women performed ultrasonic measurement abdominal circumference (AC) head (HC) at 20 28 weeks age (wkGA). Exposures were GDM ≥28 wkGA The risk AC >90th HC-to-AC ratio <10th percentile was modeled using...
The placenta is the interface between mother and fetus inadequate function contributes to short long-term ill-health. absent from most large-scale RNA-Seq datasets. We therefore analyze long small RNAs (~101 20 million reads per sample respectively) 302 human placentas, including 94 cases of preeclampsia (PE) 56 fetal growth restriction (FGR). placental transcriptome has seventh lowest complexity 50 tissues: 271 genes account for 50% all reads. identify multiple circular validate 6 these by...
Data on the birth weight-blood pressure relationship are inconsistent. Although an inverse association has been suggested in several large studies, interpretation is complicated by publication and other biases. Few data available between early growth measures blood pressure. We examined shape size of determinants fetal growth, at birth, infancy, adult systolic diastolic 31 years prospective northern Finnish 1966 cohort 5960 participants. Birth weight, length, gestational age, ponderal index,...
Several studies have shown that healthy individuals with fasting plasma glucose (FPG) levels at the high end of normal range an increased risk mortality. To identify genetic determinants contribute to interindividual variation in FPG, we tested 392,935 single-nucleotide polymorphisms (SNPs) 654 normoglycemic participants for association and replicated most strongly associated SNP (rs560887, P = 4 × 10 –7 ) 9353 participants. rs560887 maps intron 3 G6PC2 gene, which encodes...
An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We meta-analyzed associations (rs9939609) samples, aged from early infancy to 13 years, 8 cohorts of European ancestry. found a positive additional minor (A) alleles 5.5 years onwards, but an inverse below age 2.5 years. Modelling median curves for each genotype using LMS method, we that carriers showed lower infancy, earlier adiposity rebound (AR), higher later childhood. Differences by...
Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these influence height growth during childhood. We derived peak velocity in infancy (PHV1) and puberty (PHV2) timing pubertal spurt from parametric curves fitted to longitudinal data test their known variants. The study consisted N = 3,538 singletons the prospective Northern Finland Birth Cohort 1966 genotype frequent measurements (on average 20 per...
The association between maternal gestational diabetes (GDM) and manifestations of metabolic syndrome among Caucasian adolescents was studied with data from the population-based Northern Finland 1986 Birth Cohort. This is a longitudinal cohort study early pregnancy until offspring age 16 years includes risk group-based GDM screen pregnant mothers by an oral glucose tolerance test. Metabolic outcomes were compared women (OGDM; n = 95) reference group (n 3,909). prevalence overweight...