A5040426463- Skin Protection and Aging
- Photodynamic Therapy Research Studies
- Nonmelanoma Skin Cancer Studies
- Vitamin D Research Studies
- Acne and Rosacea Treatments and Effects
- melanin and skin pigmentation
- Indoor Air Quality and Microbial Exposure
- Dermatologic Treatments and Research
- Climate Change and Health Impacts
- Cutaneous Melanoma Detection and Management
- Nail Diseases and Treatments
- Urban Green Space and Health
- Allergic Rhinitis and Sensitization
- Porphyrin Metabolism and Disorders
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Cutaneous lymphoproliferative disorders research
- Air Quality and Health Impacts
- Nanoplatforms for cancer theranostics
- Optical Coherence Tomography Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Spectroscopy Techniques in Biomedical and Chemical Research
- Methemoglobinemia and Tumor Lysis Syndrome
- Ocular Infections and Treatments
- Infectious Diseases and Mycology
Copenhagen University Hospital
2015-2025
Frederiksberg Hospital
2018-2025
Bispebjerg Hospital
2015-2024
Boston College
2023
Barcelona Institute for Global Health
2023
University of Copenhagen
2012-2021
Sahlgrenska University Hospital
2011
Stavanger University Hospital
2011
Uppsala University Hospital
2011
Roskilde Sygehus
2011
Background Photodynamic therapy (PDT) is a highly effective treatment for actinic keratoses (AK); however, it time consuming and often painful the patient. Daylight-PDT would make independent of clinic less due to continuous activation small amounts porphyrins during its formation. Objectives The objective this randomized controlled study was compare response rates adverse effects after methyl aminolevulinate (MAL)-PDT using conventional red light-emitting diode (LED) light vs. daylight....
Skin lesion classification based on in vitro Raman spectroscopy is approached using a nonlinear neural network classifier. The framework probabilistic and highly automated. includes feature extraction for spectra fully adaptive robust feedforward Moreover, rules learned by the may be extracted evaluated reproducibility, making it possible to explain class assignment. performance present data set, involving 222 cases five types, was 80.5%/spl plusmn/5.3% correct of malignant melanoma, which...
<h3>Objective</h3> To assess individual time-related (time-stamped) UV radiation (UVR) dose pattern and sun exposure behavior. <h3>Design</h3> Open prospective observational study. <h3>Setting</h3> University hospital. <h3>Study Subjects</h3> Two hundred eighty-five Danish volunteers with apparently healthy skin: children, adolescents, indoor workers, worshippers, golfers, gardeners (age range, 4-68 years). <h3>Measurements</h3> We developed a personal electronic UVR dosimeter in wristwatch...
Actinic keratoses (AKs) are common dysplastic skin lesions that may differentiate into invasive squamous cell carcinomas. Although a superior cosmetic outcome of photodynamic therapy (PDT) is advantageous compared with equally effective treatments such as cryotherapy and curettage, the inconvenience clinic attendance discomfort during significant drawbacks. Daylight-mediated PDT could potentially reduce these serve an alternative to conventional PDT.To compare efficacy methyl...
Summary Background Photodynamic therapy (PDT) is an attractive for nonmelanoma skin cancers and actinic keratoses (AKs). Daylight‐mediated PDT a simple tolerable treatment procedure PDT. Methyl aminolaevulinate (MAL)‐PDT approved the of thin or nonhyperkeratotic AKs on face scalp. However, thick AK lesions are often treated as well when present in field‐cancerized area. Objectives In randomized multicentre study to evaluate efficacy daylight‐mediated different severity grades AKs. Methods...
Topical photodynamic therapy (PDT) for actinic keratoses (AK) is hampered by pain during illumination and inferior efficacy in organ-transplant recipients (OTR).We assessed ablative fractional laser (AFL)-assisted daylight (AFL-dPDT) compared with PDT (dPDT), conventional (cPDT) AFL alone (AFL) field treatment of AK OTR.In each patient, four areas the same region were randomized to one AFL-dPDT, dPDT, cPDT AFL. was delivered a 2940-nm at 2·3 mJ per pulse, 1·15 W, two stacks, 50-μs...
Sunlight contains ultraviolet (UV)A and UVB radiation. is essential for vitamin D synthesis but the main cause of sunburn skin cancer. Sunscreen use advocated to reduce sun's adverse effects may compromise status. To assess ability two intervention sunscreens inhibit during a week‐long sun holiday. The impact on status was studied 1‐week holiday in Tenerife (28° N). Comparisons were made between formulations, each with protection factor (SPF) 15. UVA‐protection (PF) low one case high other....
Abstract Raman spectroscopy provides non-destructive, label-free quantitative studies of chemical compositions at the microscale as used on NASA’s Perseverance rover Mars. Such capabilities come cost high requirements for instrumentation. Here we present a centimeter-scale miniaturization spectrometer using cheap non-stabilized laser diodes, densely packed optics, and non-cooled small sensors. The performance is comparable with expensive bulky research-grade systems. It has excellent...
Pain during photodynamic therapy (PDT) is a considerable problem that needs to be studied improve this otherwise attractive treatment of skin diseases.To compare pain PDT using two different fluence rates, and also evaluate the association between protoporphyrin IX (PpIX) fluorescence, lesion type, preparation localization.Twenty-six patients with actinic keratoses (AKs) in localizations 34 facial acne vulgaris were treated methyl aminolaevulinate-PDT. Patients illuminated rates. score PpIX...
In 1903, Niels Ryberg Finsen was awarded the Nobel Prize for his invention of light therapy skin tuberculosis (lupus vulgaris). The mechanism action has not been shown; thus, we wanted to elucidate Finsen's therapy. We measured radiation that could be transmitted through lens systems and absorption stain solution filters in lamps, related obtained results possible biological effects on Mycobacterium . Judged from transmission characteristics all tested were glass lenses (absorbing wavelength...
Background Sunscreens absorb ultraviolet B (UVB) and it is a major concern that sunscreen use may lead to vitamin D deficiency. Objectives To investigate the relation between amount of applied serum level in humans after UVB exposure under controlled conditions. Methods Thirty‐seven healthy volunteers with fair skin types were randomized receive an inorganic sun protection factor (SPF) 8 0 mg cm−2, 0·5 1 1·5 or 2 cm−2 thickness on upper body, approximately 25% body area. Participants...
Skin pretreatment is recommended for adequate penetration of topical photosensitizing agents and subsequent protoporphyrin IX (PPIX) accumulation in photodynamic therapy (PDT).To compare the relative potential different physical pretreatments to enhance PPIX fluorescence normal skin.This intraindividual, randomized clinical trial was performed from November 28 December 20, 2014, at Bispebjerg Hospital, Copenhagen, Denmark, among 12 healthy volunteers 18 years or older. Analysis based on...
Background and Objective Ablative fractional laser (AFXL) facilitates delivery of topical methotrexate (MTX). This study investigates impact laser-channel depth on MTX-delivery. Materials Methods MTX (1% [w/v]) diffused for 21 hours through AFXL-exposed porcine skin in vitro Franz Cells (n = 120). A 2,940 nm AFXL generated microscopic ablation zones (MAZs) into epidermis (11 mJ/channel, MAZ-E), superficial-dermis (26 MAZ-DS), mid-dermis (256 MAZ-DM). High performance liquid chromatography...
Background Ultraviolet (UV) B radiation increases serum vitamin D level expressed as 25‐hydroxyvitamin‐D3 [25(OH)D], but the relationship to body surface area and UVB dose needs investigation. Objective To investigate importance of on production after exposure. Methods We randomized 92 participants have 6%, 12% or 24% their skin exposed 0·75 (7·5 mJ cm−2 at 298 nm using CIE erythema action spectrum), 1·5 (15 cm−2) 3·0 (30 standard doses (SED) UVB. Each participant underwent four exposures...
Abstract Background and Objectives Treatment of a variety skin disorders with ablative fractional lasers (AFXL) is driving the development portable AFXLs. This study measures micropore dimensions produced by small 2,940 nm AFXL using stacked pulses, determines model correlating laser parameters tissue effects. Materials Methods Ex vivo pig was exposed to miniaturized AFXL, spot size 225 µm, density 5%, power levels 1.15–2.22 W, pulse durations 50–225 microseconds, repetition rates 100–500...
Background and Objective Ablative fractional laser (AFXL) is acknowledged to increase uptake of topically applied agents in skin. AFXL channels gradually close over time, which may impair this capability. The time frame for applying a drug after exposure remains be established. aim study, was investigate the importance time‐related topical application relate resultant skin with channel morphology integrity. Study Design/Materials Methods Buttock healthy volunteers ( n = 11) exposed 10,600 nm...
Epidemiology suggests that melanin inhibits cutaneous vitamin D3 synthesis by UVR. Laboratory investigations assessing the impact of on D production have produced contradictory results. We determined effect photosynthesis in healthy young volunteers (n = 102) Fitzpatrick skin types II-VI (white to black). Participants, irrespective type, were exposed same suberythemal UVR dose, 85% body surface area, using solar simulated or narrowband UVB (311 nm). This was repeated five times with...
Abstract The tape stripping technique is increasingly used in research regarding skin barrier function. However, number of strips varies between studies, and literature considering advancement into stratum corneum/epidermis relation to scarce. aim this pilot study was assess the through epidermis using healthy volunteers. A total ten volunteers were included. From all 0, 5, 15 35 consecutive (D-squame) taken from four adjacent areas on middle volar forearm, followed by Reflectance Confocal...
Action spectra are important biological weighting functions for risk/benefit analyses of ultraviolet (UV) radiation (UVR) exposure. One human benefit exposure to terrestrial solar UVB (∼295 315 nm) is the cutaneous synthesis vitamin D