A5050152413- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Drug Solubulity and Delivery Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Microfluidic and Capillary Electrophoresis Applications
- Phase Equilibria and Thermodynamics
- Polymer Foaming and Composites
- Injection Molding Process and Properties
- Bioinformatics and Genomic Networks
- Nanofabrication and Lithography Techniques
- Electrical and Bioimpedance Tomography
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- Inhalation and Respiratory Drug Delivery
- Optical Coherence Tomography Applications
- Microfluidic and Bio-sensing Technologies
- Electrohydrodynamics and Fluid Dynamics
- Geophysical Methods and Applications
- Anesthesia and Sedative Agents
- Gene Regulatory Network Analysis
- Balance, Gait, and Falls Prevention
- Ferroptosis and cancer prognosis
Danish National Research Foundation
2019-2024
Technical University of Denmark
2015-2024
The Velux Foundations
2019-2024
Ørsted (Denmark)
2017-2024
Hebrew University of Jerusalem
2020-2023
I.R.C.C.S. Oasi Maria SS
2023
Istituto Nazionale di Riposo e Cura per Anziani
2023
University of Trento
2020
Nanoprobes (United States)
2018-2019
Texas Tech University Health Sciences Center
2019
Mode of delivery strongly influences the early infant gut microbiome. Children born by cesarean section (C-section) lack Bacteroides species until 6-18 months age. One hypothesis is that these differences stem from exposure to maternal vaginal Here, we re-evaluate this comparing microbial profiles 75 infants vaginally or planned versus emergent C-section. Multiple children C-section have a high abundance in their first few days life, but at 2 weeks, both groups (primarily according 16S...
Abstract Raman spectroscopy provides non-destructive, label-free quantitative studies of chemical compositions at the microscale as used on NASA’s Perseverance rover Mars. Such capabilities come cost high requirements for instrumentation. Here we present a centimeter-scale miniaturization spectrometer using cheap non-stabilized laser diodes, densely packed optics, and non-cooled small sensors. The performance is comparable with expensive bulky research-grade systems. It has excellent...
We demonstrate the first complete study on fabrication of biodegradable microcontainers including their evaluation <italic>in vitro</italic> and vivo</italic>.
The Cancer Genome Atlas (TCGA) and analogous projects have yielded invaluable tumor-associated genomic data. Despite several web-based platforms designed to enhance accessibility, certain analyses require prior bioinformatic expertise. To address this need, we developed Gene ENrichment Identifier (GENI, https://www.shaullab.com/geni), which is promptly compute correlations for genes of interest against the entire transcriptome rank them well-established biological gene sets. Additionally, it...
Recent advances in the use of nano- and microparticles drug delivery, cell therapy, tissue engineering have led to increasing attention towards nanostructured microparticulate formulations for maximum benefit from both micron sized features. Scalable manufacturing monodisperse with tunable size, shape, content, release rate remains a big challenge. Current technology, mainly comprises complex multi-step chemical procedures limited control over these aspects. Here, we demonstrate novel...
We present the characterisation and validation of multiplexed 4-terminal (4T) impedance measurements as a method for sensing spatial location cell aggregates within large three-dimensional (3D) gelatin scaffolds. The were performed using an array four rectangular chambers, each having eight platinum needle electrodes parallel analysis. electrode positions current injection voltage optimised by means finite element simulations to maximise sensitivity field distribution resolution. Eight...
Abstract Oral delivery of proteins and peptides is one the main challenges in pharmaceutical drug development. Microdevices have possibility to protect therapeutics until release desired, avoiding losses by degradation. One type microdevice polymeric microcontainers. In this study, lysozyme chosen as model protein loaded into microcontainers with permeation enhancer sodium decanoate (C10). The are sealed functionalized applying lids onto cavity devices. first lid poly(lactic‐ co ‐glycolic)...
Abstract Current in vitro drug screening methods often rely on single‐cell models and are therefore imprecise predicting absorption, distribution, metabolism, excretion, toxicity. This study presents a method to fabricate 3D printed inserts that compatible with commercially available titer plates. Hydrogels can be casted into the cells cultured either or hydrogels. Once individual cell cultures fully differentiated, three different stacked top of each other for biological experiments. To...
Abstract The ability to image drug distribution inside a several hundred micron thick polymer matrix, encapsulated by protective coating, would greatly contribute the understanding of performance and shortcomings delivery devices. Here, we present an experimental framework for deep volumetric Raman imaging (dVRI), where common challenges such as low cross section, fluorescence, transparency samples are overcome. We apply dVRI selection forms, tablets with thin coatings drug‐loaded...
The automatic discovery of causal relationships among human genes can shed light on gene regulatory processes and guide drug repositioning. To this end, a computationally-heavy method for is distributed volunteer computing grid and, taking advantage variable subsetting stratification, proves to be useful expanding local networks. input data are purely observational measures transcripts expression in tissues cell lines collected within the FANTOM project. system relies BOINC platform...
To enhance oral bioavailability of poorly soluble drugs, microfabricated devices can be utilized. One example such is microcontainers. These are cylindrical in shape with an inner cavity for drug loading and only the top side open release. Supercritical CO2 (scCO2) impregnation interesting technique drugs into polymeric matrices in, example, microcontainers since it avoids use organic solvents cheap. main drawbacks this unknown three-dimensional distribution polymer matrix. The aim study was...
Worldwide, life expectancy has steadily increased over the years.However, integrity and functionality of physiological systems reduce time making older people more vulnerable to adverse events such as falls.Consequences falls can include physical injuries (hip fractures), psychological issues (fear falling) social isolation (need for assistance) increasing demand healthcare services (hospitalization, rehabilitation, institutionalization).Despite many studies investigated most predisposing...
As life expectancy increases, the likelihood of more falls and fall-related hospitalizations increases with a significant impact on health system. Given high incidence in healthy elderly people, order to prevent them, it is necessary identify predisposing risk factors, analyze specific needs subjects use targeted preventive strategy. This paper investigates influence multidimensional parameters fall community-dwelling older living inner areas Marche Region (Italy). Multidimensional data...