A5083601162- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Thermodynamic properties of mixtures
- Analytical Chemistry and Chromatography
- Spectroscopy and Quantum Chemical Studies
- Advanced Chemical Sensor Technologies
- Phase Equilibria and Thermodynamics
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Polymer Foaming and Composites
- Injection Molding Process and Properties
- Optical Coherence Tomography Applications
- Water Quality Monitoring and Analysis
- Carbon Nanotubes in Composites
- Methane Hydrates and Related Phenomena
- Plasmonic and Surface Plasmon Research
- Nanofabrication and Lithography Techniques
- Nonlinear Optical Materials Studies
- 2D Materials and Applications
- Photonic and Optical Devices
- Micro and Nano Robotics
- Protein Interaction Studies and Fluorescence Analysis
- Drug Solubulity and Delivery Systems
- Advanced Fluorescence Microscopy Techniques
- MXene and MAX Phase Materials
Technical University of Denmark
2018-2024
Danish National Research Foundation
2019-2022
The Velux Foundations
2019-2022
Ørsted (Denmark)
2019-2022
In JeT ApS (Denmark)
2022
Nanoprobes (United States)
2019
D.F. Chebotarev Institute of Gerontology
2016-2018
National Academy of Medical Sciences of Ukraine
2016-2017
Taras Shevchenko National University of Kyiv
2014
Abstract Raman spectroscopy provides non-destructive, label-free quantitative studies of chemical compositions at the microscale as used on NASA’s Perseverance rover Mars. Such capabilities come cost high requirements for instrumentation. Here we present a centimeter-scale miniaturization spectrometer using cheap non-stabilized laser diodes, densely packed optics, and non-cooled small sensors. The performance is comparable with expensive bulky research-grade systems. It has excellent...
Abstract Non-destructive orientation mapping is an important characterization tool in materials science and geoscience for understanding and/or improving material properties based on their grain structure. Confocal Raman microscopy a powerful non-destructive technique chemical of organic inorganic materials. Here we demonstrate by means Polarized Microscopy (PRM). While the concept that PRM sensitive to changes known, our knowledge, actual quantitative has never been presented before. Using...
Oral administration of drugs has received significant attention in the last 1, 2 decades, as it is most comfortable and painless route, which leads to high patient compliance. Although oral delivery shows positive effects patients, several hurdles must be overcome such enzymatic degradation, large pH-variations found throughout gastrointestinal (GI) tract, continuous mucus secretion. We have studied biocompatible non-toxic micromotors promising man-made microdevices for targeted furosemide...
We present the development of an automated centrifugal microfluidic platform with integrated sample pre-treatment (filtration and liquid-liquid extraction) detection (SERS-based sensing). The consists eight calibration four assay modules, fabricated polypropylene using injection molding bonded ultrasonic welding. was used for a secondary bacterial metabolite (p-coumaric acid) from supernatant. obtained extraction efficiency comparable to values in batch experiments SERS-based sensing showed...
We have recorded attenuated total reflection infrared spectra of binary mixtures in the (quasi-)ideal systems benzene-toluene, benzene-carbon tetrachloride, and benzene-cyclohexane. used two-dimensional correlation spectroscopy, principal component analysis, multivariate curve resolution to analyze data. The 2D proves nonlinearities, also spectral ranges with no obvious deviations from Beer's approximation. number components is much higher than two carried out under assumption presence a...
Abstract Conventional photopolymerization-based 3D printing still requires developing a concise and cost-effective method to improve the resolution at nanoscale. Here, we propose use of gaming console optical drive pickup unit for photopolymerization. This mass-produced features finely adjustable diode laser, allowing us adjust from tens micrometres down hundreds nanometres without requiring oxygen radical scavenging or costly femtosecond lasers. We evaluate performance using commercial...
An application of 2D-BN nanoparticles as a spectroscopic marker, weak luminescent marker and anticancer drug (doxorubicin, DOX) delivery system with protection properties was studied for the LNCaP strains cancer cells using FTIR Raman spectroscopy analysing cells, BN, DOX, BN loaded by DOX. Study IR absorption spectra incubated 1 hour showed that could pass through cell membrane localize inside or close to in cytoplasm cells. We registered disturbed lipids during DOX-2D-BN passing membrane....
Raman spectroscopy combined with augmented reality and mixed to reconstruct molecular information of tissue surface.
MoS2 nanoribbons have attracted increased interest due to their properties, which can be tailored by tuning dimensions. Herein, the growth of and triangular crystals formed reaction between films MoOx (2<x<3) grown pulsed laser deposition NaF in a sulfur-rich environment is demonstrated. The reach up 10 µm length, feature single-layer edges, forming monolayer-multilayer junction enabled lateral modulation thickness. edges show pronounced second harmonic generation symmetry breaking, contrast...
Blood analysis by spectroscopic techniques can provide important information about biochemistry and life processes in it. indices are highly variable, plenty of factors influence them. The present work describes the combination two methods – IR Raman spectroscopies blood applied to investigate gerontology issues. We carried out a pilot study 74 samples. donors were differentiated age with Partial Least Squares (PLS) spectra. Analyzing principal component spectra obtained during PLS processn...
Crystalline solids can incorporate water molecules into their crystal lattice causing a dramatic impact on properties. This explains the increasing interest in understanding dehydration pathways of these solids. However, classical thermal analytical techniques cannot spatially resolve pathway organic hydrates at single particle level. We have developed new method for imaging using Raman line-focus microscopy during heating particle. Based this approach, we propose metastable intermediate...
Pure beta silicon carbide of submicron and micron particle size has been synthesized via carbothermal reduction nanosilica. The resulted powder its carbon-silica precursor were characterized by means FTIR spectroscopy, electron microscopy, X-ray diffraction. results TGA-DSC-MS analysis indicate a possibility to estimate this technique the carbon content in as well residual with sensitivity about 5 ppm.
The wide and ever-increasing applications of thermoplasmonics demand the need for sensitive reliable tools to probe optical absorptions individual nanoparticles. However, most currently available techniques focus only on measuring surface temperature nanostructures in a particular medium are either invasive or suffer from low sensitivity, lengthy calibration, inability single structures with nanogaps. Here, we present first time use micromechanical SiN string resonators quantifying...
The possibilities of the decomposition by non-negative least squares (NNLS) and Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) methods determination spectra concentrations species in multicomponent (up to 8) liquid solutions analyzing FTIR ATR Raman are discussed. It is shown that NNLS provides better results than same mixture measured with method. This fact connected narrower width smaller overlap vibrational peaks obtained use spectroscopy comparing IR for molecular...
Abstract The ability to image drug distribution inside a several hundred micron thick polymer matrix, encapsulated by protective coating, would greatly contribute the understanding of performance and shortcomings delivery devices. Here, we present an experimental framework for deep volumetric Raman imaging (dVRI), where common challenges such as low cross section, fluorescence, transparency samples are overcome. We apply dVRI selection forms, tablets with thin coatings drug‐loaded...
Methanol-chloroform solutions with different mixing ratios were studied using vibrational (ATR FTIR and Raman) spectroscopy. Obtained spectra analyzed by techniques such as excess spectroscopy multivariate curve resolution. Analysis of showed that the investigated consist four kinds species: ‘pure’ methanol, chloroform, two types ‘effective’ molecular complexes. Molecular complexes present in entire concentration range methanol dilutions chloroform. spectral profiles chloroform identical to...
Комплексоутворення РНК з манітолом, його спектральні характеристики та біологічна активність (Представлено членом-кореспондентом НАН України Д.М
We combine liquid–liquid extraction, SERS detection and partial least squares analysis for simultaneous quantification of bacterial metabolites in <italic>E. coli</italic> supernatant.
Abstract Surface‐enhanced Raman spectroscopy (SERS)‐based molecular detection at extremely low concentrations often relies on mapping of a SERS substrate. This yields large number (>1000) spectra that can improve the limit detection; however, signal collection time is major constraint. In this work, wide line (WL) laser focusing technique aimed fast substrates presented. The WL enables acquisition thousands in few seconds without missing any electromagnetic “hot spots” illuminated area....
The actual binary (double) solutions of “acetone–chloroform” and “ethyl acetate–cyclohexane” are simulated as ideal multi-component (triple, quadruple) mixtures, which consist associates [Ap], [Bq], complexes [AnBm]. MCR-ALS method is used for the analysis near-IR absorption spectra. Complexes a single type [A1B1] determined in an acetone–chloroform solution, two types, [X1Y1] [X5Y1], ethyl acetate–cyclohexane solution. An auxiliary determining number by analyzing residual intensity IR...
Mutual diffusion in multicomponent liquids is studied. It taken into consideration that the influence of complex formation on process may be substantial. The theory applied to analyze mass transfer an acetone-chloroform solution. molecular concentration was obtained from analysis Fourier transform infrared spectra this Taking account allows one explain experimental dependence coefficients composition (components concentration). accuracy and theoretical data descriptions frame our model...
To enhance oral bioavailability of poorly soluble drugs, microfabricated devices can be utilized. One example such is microcontainers. These are cylindrical in shape with an inner cavity for drug loading and only the top side open release. Supercritical CO2 (scCO2) impregnation interesting technique drugs into polymeric matrices in, example, microcontainers since it avoids use organic solvents cheap. main drawbacks this unknown three-dimensional distribution polymer matrix. The aim study was...