A5008559800- Nonmelanoma Skin Cancer Studies
- Birth, Development, and Health
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Urticaria and Related Conditions
- Occupational exposure and asthma
- Erythrocyte Function and Pathophysiology
- Wnt/β-catenin signaling in development and cancer
- Autoimmune Bullous Skin Diseases
- Skin and Cellular Biology Research
- Childhood Cancer Survivors' Quality of Life
- Cutaneous lymphoproliferative disorders research
- Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Neonatal Respiratory Health Research
- Dermatology and Skin Diseases
- Renal and related cancers
- Hedgehog Signaling Pathway Studies
- Cytomegalovirus and herpesvirus research
- Connexins and lens biology
- Hereditary Neurological Disorders
- Infectious Diseases and Mycology
- Asthma and respiratory diseases
Gentofte Hospital
2012-2025
Copenhagen University Hospital
2019-2025
University of Copenhagen
2014-2021
The University of Queensland
2020
Rigshospitalet
2019
Capital Region of Denmark
2015-2016
Statens Serum Institut
2000-2004
Danish National Research Foundation
2001
Topical photodynamic therapy (PDT) for actinic keratoses (AK) is hampered by pain during illumination and inferior efficacy in organ-transplant recipients (OTR).We assessed ablative fractional laser (AFL)-assisted daylight (AFL-dPDT) compared with PDT (dPDT), conventional (cPDT) AFL alone (AFL) field treatment of AK OTR.In each patient, four areas the same region were randomized to one AFL-dPDT, dPDT, cPDT AFL. was delivered a 2940-nm at 2·3 mJ per pulse, 1·15 W, two stacks, 50-μs...
The aim of this study was to examine the validity a Danish adaptation Itch Severity Scale (ISS) by exploring associations between pruritus severity, psychological symptoms, and quality life in consecutively recruited sample 20 patients with atopic dermatitis, psoriasis, urticaria, 12 genital pruritus, 11 nephrogenic controls vascular malformations. Convergent discriminative explored analysing ISS total score individual component scores age, sex, diagnosis, disease sleep quality, depressive...
The subjective dimensions of pruritus and their associations with psychological symptoms quality life were explored in a sample 40 psoriasis patients. patients completed scale descriptors from the Structured Itch Questionnaire together measures depression, distress, sleep pruritus-related life. Psoriasis severity was assessed Area Severity Index. Factor analysis confirmed both an affective sensory dimension. Multivariate statistics, controlling for age, gender, disease duration severity,...
Ectodermal dysplasias constitute a group of rare genetic disorders the skin and appendages with hypodontia, hypotrichosis, hypohidrosis as cardinal features. There is lack population-based research into epidemiology ectodermal dysplasias.
Background and Objectives: Solid organ transplant recipients (SOTRs) are at increased risk of skin cancer suffer from greater disease-specific morbidity mortality. To stratify the expanding SOTR population for more targeted screening, a detailed understanding factors is needed. Using combined clinical pathological data to capture prevalence actinic keratosis (AK) cancer, this study aimed identify development in Danish cohort. Methods: The trial comprised retrospective cohort patients...
Abstract Patients with ataxia-telangiectasia (A-T) lack a functional ATM kinase protein and exhibit defective repair of DNA double-stranded breaks response to oxidative stress. We show that CRISPR/Cas9-assisted gene correction combined piggyBac (PB) transposon-mediated excision the selection cassette enables seamless restoration alleles in induced pluripotent stem cells from an A-T patient carrying compound heterozygous exonic missense/frameshift mutations, homozygous splicing acceptor...
Background The study aimed to describe genotype-phenotype associations in patients with oculocutaneous and ocular-only albinism evaluate a set of diagnostic criteria proposed recently by Kruijt et al.Materials methods Genotype-phenotype clinical diagnosis were studied based on imaging hair ocular features (nystagmus, iris color translucency, fundus pigmentation foveal development) self-evaluated skin type. Patients sub-grouped genetic findings.Results biallelic variants TYR (n = 29), OCA2...
In Brief Objective To determine the risk of adverse pregnancy outcome by maternal serum alpha-fetoprotein (MSAFP) level. Methods We followed 77,149 pregnant women and their infants from MSAFP screening in 15th to 20th week gestation until 1 year after birth. Information on was obtained national registries. The relative risks (RRs) 95% confidence intervals (CIs) for were estimated according level MSAFP, with adjustment confounders. Results A total 638 pregnancies resulted spontaneous...
Gorlin syndrome is mainly caused by pathogenic germline variants in the tumour suppressor genes PTCH1 and SUFU, both regulatory hedgehog pathway. However, phenotypes of patients with SUFU seem to differ. We present a family frameshift variant gene c.954del, p.Asn319Thrfs∗42 leading meningiomas multiple basal cell-carcinomas.
The small molecule vismodegib is a great treatment alternative to patients challenged, e.g. psychiatric disorders, suffering from severe basal cell carcinoma of the skin in which surgery or other modalities not possible because patient's wish condition. We present case 73-year-old schizophrenic patient with 15-year history neglected tumour located at forehead and scalp, admitted hospital state inanition expansion meninges anaemia caused by bleeding, treated successfully vismodegib.
One of the more consistent findings in leukemia research is association between birth weight and childhood leukemia. Because thyroid hormones are critically involved growth differentiation, we speculated that hormone levels could be significance to development early life. Specifically, hypothesized high thyroid-stimulating (TSH) would associated with a low risk Accordingly, TSH (low free hormone) after most likely reflects function accompanied by rate cell turnover so lower faulty divisions...
Background. Levels of maternal alpha‐fetoprotein (AFP) are increased during multiple gestations and preeclampsia but little is known regarding AFP levels in relation to other reproductive factors. Consequently, the objective this work was describe possible relationship between pregnancy age at birth, first parity, time since previous birth gender offspring. Methods. Based on national registries we obtained history a population‐based cohort 44 227 women who had serum determined gestational...
Abstract Background Rates of keratinocyte carcinoma (KC) across Europe are impacted by population demographics and geography. Regional differences in KC occurrence exist, but few European studies investigate incidences specific subtypes the secondary healthcare sector on a national level. Objectives To determine geographical incidence rate lifetime risk Denmark, including nodular superficial basal cell (BCC), squamous (SCC) precursor, Bowen's disease (BD), identified office‐based...
Importance Palmoplantar keratoderma poses diagnostic challenges due to its clinical and genetic heterogeneity, knowledge on the value of systematic testing clinically well-described patient cohorts is sparse. Objective To improve spectrum patients with palmoplantar keratoderma. Design, Setting, Participants This cohort study prospectively recruited affected family members between September 1, 2016, December 31, 2022. Patients were from private practitioners in dermatology departments...
Background. Levels of maternal alpha-fetoprotein (AFP) are increased during multiple gestations and preeclampsia but little is known regarding AFP levels in relation to other reproductive factors. Consequently, the objective this work was describe possible relationship between pregnancy age at birth, first parity, time since previous birth gender offspring. Methods. Based on national registries we obtained history a population-based cohort 44 227 women who had serum determined gestational...