A5051046432- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Connexins and lens biology
- Corneal surgery and disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Circadian rhythm and melatonin
- Advanced Glycation End Products research
- Ocular and Laser Science Research
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- melanin and skin pigmentation
- Impact of Light on Environment and Health
- Ocular Infections and Treatments
- Connective tissue disorders research
- Skin Protection and Aging
- Biochemical effects in animals
- Optical Imaging and Spectroscopy Techniques
- Ophthalmology and Eye Disorders
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Health Research
- Migraine and Headache Studies
Glostrup Hospital
2015-2025
University of Copenhagen
2016-2025
Rigshospitalet
2016-2025
Copenhagen University Hospital
2009-2025
Capital Region of Denmark
2025
Aarhus University
2022
Kennedy Center
2019-2021
Danmarks Frie Forskningsfond
2020
Roskilde Sygehus
2015-2016
Danish Business Authority
2014-2015
PURPOSE: To characterize age-related changes in the transmission of light through noncataractous human lenses. SETTING: Department Ophthalmology, Glostrup Hospital, Glostrup, Denmark. METHODS: The spectral white was measured along visual axis most central part lens vitro intact donor lenses over a wide range ages. RESULTS: study evaluated 28 15 donors aged 18 to 76 years. Increasing age associated with gradually decreasing at all visible wavelengths, prominently shorter wavelengths....
To determine the myopia prevalence in a Danish cohort aged 16-17 years and its relation to physical activity use of screen-based electronic devices.The Copenhagen Child Cohort 2000 Eye Study is prospective, population-based, observational study. Information about screen devices was obtained using questionnaires. Myopia defined as non-cycloplegic subjective spherical equivalent refraction ≤-0.50 D right eye.We included 1443 participants (45% boys) with median age (±IQR) 16.6 (±0.3). The 25%...
To characterize the genotypic and phenotypic spectrum of foveal hypoplasia (FH).Multicenter, observational study.A total 907 patients with a confirmed molecular diagnosis albinism, PAX6, SLC38A8, FRMD7, AHR, or achromatopsia from 12 centers in 9 countries (n = 523) extracted publicly available datasets previously reported literature 384).Individuals availability OCT scans were identified between January 2011 March 2021. A genetic was by sequence analysis. Grading FH derived scans.Grade FH,...
Exposure to elevated ambient temperatures has been mentioned as a risk factor for common eye diseases, primarily presbyopia and cataract. The aim of the present study was examine relationship among ambient, cornea, body core temperature.The relation between corneal temperature examined in 11 human volunteers. Furthermore, measured using thermal camera during elevation three volunteers four rats.A linear found rat. For humans there an initial increase with increasing temperature, but seemed...
Sleep pattern and circadian rhythms are regulated via the retinohypothalamic tract in response to stimulation of a subset retinal ganglion cells, predominantly by blue light (450–490 nm). With age, transmission retina is reduced because aging process human lens, this may impair photoentrainment rhythm leading sleep disorders. The aim study was examine association between lens Cross-sectional population based study. performed at Research Center for Prevention Health, Glostrup Hospital,...
Abstract Background The activity of melanopsin containing intrinsically photosensitive ganglion retinal cells (ipRGC) can be assessed by a means pupil responses to bright blue (appr.480 nm) light. Due age related factors in the eye, particularly, structural changes lens, less light reaches retina. aim this study was examine how and vivo measured lens transmission might affect responses, particular, mediated ipRGC. Methods Consensual were explored 44 healthy subjects aged between 26 68 years....
Abstract Purpose Children born preterm are believed to be at increased risk of visual impairment (VI). The survival rate extremely children may have changed the spectrum diseases occurring postnatally. aim this study was analyse prevalence and causes VI in an ex‐preterm Danish population during last 4 decades. Methods based on National Register Blind Visually Impaired (NRVIC). Ex‐preterms gestational age (GA) <32 weeks enrolled NRVIC any time between 1988 2020 were included. main cause...
Abstract Purpose The aim of the study was to describe temporal changes in causes and prevalence childhood visual impairment Denmark based on National Danish Registry Children with Visual Impairment (NDRCVI). Methods Annual reports NDRCVI since its establishment 1979 were reviewed data number registered children for registration a evaluated. Results average annual incidence is 2.8 per 1000 live‐born 1.6 <18 years. Today, fewer are severely visually impaired (visual acuity ≤6/60) at time...
Bilateral childhood cataracts may be caused by genetic changes, metabolic disease, infections or secondary to trauma, radiation drug use. We reviewed 211 Danish children with bilateral and found that 29.4% had hereditary cataract at least one affected first‐degree family member, alone accounted for 8.1% of all cases cataract. A cause been non‐routine screening in 35.1% children. In a large number children, the was associated systemic diseases syndromes whereas isolated were only 27.0% This...
Benign recurrent sixth nerve palsy is a rare phenomenon, and the majority of reported cases suffer from their first episode in early childhood. In this case report, we present benign isolated left 6th nine-year-old boy. All episodes were precipitated by an upper respiratory tract infection resolved within 2-3 weeks. Extensive investigations with two MRI scans, lumbar punctures several blood tests showed no underlying cause. This diagnosis exclusion worth considering otherwise well-appearing...
Abstract Purpose Preterm birth is associated with a risk of ocular complications. The primary aim the study was to evaluate main cause visual impairment (VI) in cohort preterm born patients who had childhood‐onset VI. association between health‐related quality life (HRQoL) and age, cause—and severity VI type assessed. Methods In Denmark, <18 years are enrolled at National Danish Registry Children Visual Impairment (NDRCVI). Patients NDRCVI any time 1988 2020 were invited for follow‐up...
Oculocutaneous albinism (OCA) is genetically and clinically heterogeneous recessive disorders with at least 23 associated genes. Isolated OCA characterized by hypopigmentation in the skin, hair, eyes combined ocular abnormalities. Hermansky Pudlak syndrome (HPS) Chediak-Higaski are syndromic forms of OCA, distinguished immunological hematological symptoms addition to anomalies. Targeted clinical care crucial for patients molecular genetic diagnosis important classification patients. Current...
To investigate levels of specific plasma-biomarkers related to neurodegeneration and inflammation in patients with different chronic degenerative retinal diseases, using an ultrasensitive technology called ‘single molecule array’ (SiMoA). Also, if biomarkers were measurable the patient’s blood, dependent on age medical comorbidities, useful for stratifying diseases. This exploratory, cross-sectional study recruited 151 adults at Department Ophthalmology, Rigshospitalet, Denmark (period 2019...
Aim To examine the safety and efficacy of low-dose atropine (0.01% 0.1% loading dose) after 2-year treatment 1-year washout in 6-year-old to 12-year-old Danish children with myopia. Methods Investigator-initiated, placebo-controlled, double-blind, randomised clinical trial. Of 124 screened children, 97 were receive 0.01% for 24 months (0.01%) or 6 months, then 18 (0.1% placebo, followed by a washout. Altogether, 91 participants completed study. The primary outcome was myopia progression...
To assess the relative influence of genetic and environmental effects on retinal vessel diameters blood pressure in healthy adults, as well possible connection between these two characteristics.In 55 monozygotic 50 dizygotic same-sex twin pairs, aged 20 to 46 years, interpolated diameter estimates for central artery (CRAE), vein (CRVE), artery-to-vein ratio (AVR) were assessed by analysis digital gray-scale fundus photographs right eyes.The heritability was 70% (95% CI: 54%-80%) CRAE, 83%...
<h3>Background/aims:</h3> To assess the relative influence of genetic and environmental factors on retinal arterial tortuosity association between various health indices in healthy young to middle-aged persons. <h3>Methods:</h3> This cross-sectional study included 57 monozygotic 52 dizygotic same-sex twin pairs, aged 20 46 years, who were characterised by determination vessel diameters, blood pressure, glucose, body mass index, smoking habits tortuosity, using a three-level grading scale...
Cataract decreases blue light transmission. Because of the selective sensitivity retinal ganglion cells governing circadian photoentrainment, cataract may interfere with normal sleep-wake regulation and cause sleep disturbances. The purpose was to investigate effect surgery on photoentrainment determine any difference between blue-blocking neutral intraocular lenses (IOLs).The study a single-center, investigator-driven, double-masked, block-randomized clinical trial.One eye in 76 patients...
Purpose. To describe associations between retinal vessel diameters and cardiovascular risk markers mortality. Methods. The present study included 908 persons aged 30 to 60 years. Vessel were expressed as central venular equivalent (CRVE) arteriolar (CRAE). Multiple linear regression analyses Cox models used. Results. showed that narrower CRAE was associated with higher systolic blood pressure, age, HDL cholesterol, whereas wider CRVE smoking. Narrower cholesterol. In an age-adjusted model,...