A5005931904- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Multiple Sclerosis Research Studies
- Cancer Treatment and Pharmacology
- Ovarian cancer diagnosis and treatment
- Angiogenesis and VEGF in Cancer
- Colorectal Cancer Treatments and Studies
- Diet and metabolism studies
- Rheumatoid Arthritis Research and Therapies
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Genetic factors in colorectal cancer
- Pharmacogenetics and Drug Metabolism
- Metabolomics and Mass Spectrometry Studies
- Alzheimer's disease research and treatments
- Peripheral Neuropathies and Disorders
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Colorectal Cancer Surgical Treatments
- Sarcoidosis and Beryllium Toxicity Research
- COVID-19 Clinical Research Studies
- Biosensors and Analytical Detection
- S100 Proteins and Annexins
Vejle Sygehus
2010-2025
University of Southern Denmark
2006-2025
Region of Southern Denmark
2025
University of North Texas
2025
University of North Texas Health Science Center
2025
Lillebaelt Hospital
2009-2024
Aalborg University Hospital
2023
Odense University Hospital
2012
The outbreak of the coronavirus disease (COVID-19) pandemic caused by novel (SARS-CoV-2) has been declared an international public health crisis. It is essential to develop diagnostic tests that can quickly identify infected individuals limit spread virus and assign treatment options. Herein, we report a proof-of-concept label-free electrochemical immunoassay for rapid detection SARS-CoV-2 via spike surface protein. assay consists graphene working electrode functionalized with anti-spike...
Paclitaxel-induced peripheral neuropathy (PIPN) is a barrier to effective cancer treatment and impacts quality of life among patients with cancer. We used translational approach assess the utility neurofilament light chain (NFL) as biomarker PIPN in human cell model ovarian measured NFL medium from induced pluripotent stem cell-derived sensory neurons (iPSC-SNs) exposed paclitaxel. Serum (sNFL) levels were quantified 190 receiving paclitaxel/carboplatin chemotherapy at baseline after each...
Background: This study investigates clinical and biomarker differences between standard interval dosing (SID) extended (EID) of ocrelizumab therapy in multiple sclerosis (MS). Methods: is a prospective, double-arm, open-label, multi-center Denmark. Participants diagnosed with MS on >12 months were included ( n = 184). Clinical, radiological, blood-based outcomes evaluated. MRI disease activity, relapses, worsening neurostatus, No Evidence Disease Activity-3 (NEDA-3) used as combined...
Abstract Objectives We hypothesized that the amount of antigen produced in body during a COVID-19 infection might differ between patients, and maximum concentrations would predict degree both inflammation outcome for patients. Methods Eighty-four hospitalized SARS-CoV-2 PCR swab-positive were followed with blood sampling every day until discharge or death. A total 444 serial EDTA plasma samples analyzed range biomarkers: nuclear RNA concentration, complement activation as well several...
Abstract Introduction Alzheimer’s Disease (AD) is complex and novel approaches are urgently needed to aid in diagnosis. Blood frequently used as a source for biomarkers; however, its complexity prevents proper detection. The analytical power of metabolomics, coupled with statistical tools, can assist reducing this complexity. Objectives Thus, we sought validate previously proposed panel metabolic blood-based biomarkers AD expand our understanding the pathological mechanisms involved that...
To investigate levels of specific plasma-biomarkers related to neurodegeneration and inflammation in patients with different chronic degenerative retinal diseases, using an ultrasensitive technology called ‘single molecule array’ (SiMoA). Also, if biomarkers were measurable the patient’s blood, dependent on age medical comorbidities, useful for stratifying diseases. This exploratory, cross-sectional study recruited 151 adults at Department Ophthalmology, Rigshospitalet, Denmark (period 2019...
Purpose To investigate predictive potential of growth and metabolic blood biomarkers in the development milder, reversible retinopathy prematurity (ROP) stages. Methods Biomarkers were obtained from samples collected every second postnatal week a prospective, longitudinal cohort study including 108 infants born with gestational age (GA) <32 weeks four hospitals Capital Region Denmark, 2018–2019. ROP diagnoses electronic medical record system together demographic, clinical laboratory data....
Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (PCSM-TCLPD) is a rare condition that typically manifests as solitary, asymptomatic nodule. Systemic involvement uncommon, and diagnosis confirmed via biopsy, which reveals predominant population of CD4-positive T-cells with follicular helper phenotype. Treatment generally involves conservative local approaches, including topical steroids, or excision, many cases demonstrating spontaneous regression after biopsy. This...
Abstract Purpose Oxaliplatin-induced peripheral neuropathy (OIPN) is a chronic, debilitating late effect following oxaliplatin treatment. Neurofilament light chain (NfL) structural protein found in nerve axons that was investigated upon exposure vitro and vivo correlated to symptoms of OIPN colorectal cancer patients receiving oxaliplatin. Methods Human sensory neurons, derived from induced pluripotent stem cells, were exposed clinically relevant concentrations vitro, with NfL measured the...
Cognitive impairment in type 2 diabetes is associated with cerebral glucose hypometabolism. Providing a substitute such as ketone bodies might restore metabolic balance glucose-compromised neurones and improve cognitive performance. We aimed to investigate if β-hydroxybutyrate (ketone body) infusion acutely affects performance, measured by neuropsychological test battery, patients diabetes.Randomised, placebo-controlled, double-blind cross-over trial.Eighteen received i.v. body...
To assess if SARS-CoV-2 (COVID-19) systemic disease can be determined by available nucleoprotein assays, we compared the performance of three commercial (N) assays in plasma. A total 272 plasma samples collected period November-December 2021 were analyzed methods Simoa SARS CoV-2 N Protein Advantage Kit [Quanterix Simoa], Solsten Antigen enzyme immunosorbent assay (ELISA) [Solsten ELISA], and Elecsys electrochemiluminescence immunoassay [Elecsys ECLIA]. Additionally, a dilution series...
The epidermal growth factor receptors, HER1, HER2, HER3 and HER4 play a key role in the of malignant tumors. receptors EGF receptor family are not cancer-specific proteins since these expressed to some extent both normal benign tissue, but this is elucidated detail ovarian tissue. High tumor-to-normal-tissue concentration ratios would be favorable for molecular targeted anti-cancer treatment. primary aim study was analyze potential differential protein content gene expression four Tissue...
Anti-VEGF treatment has proven effective in recurrent ovarian cancer. However, the identification of patients most likely to respond is still pending. It well known that angiogenesis regulated by several other pro-angiogenic proteins, e.g. platelet - derived growth factor (PDGF) system and fibroblast (FGF) system. These signaling pathways may remain active or become upregulated during anti-VEGF treatment. The aim present study was investigate if potential changes PDGF-BB, PDGF-AA, FGF2...
EGFR immunohistochemistry (IHC) status is not a reliable predictive marker for response to EGFR-targeted therapies. The present study compares the at DNA, RNA and protein level. Blood samples, corresponding normal colon colorectal cancer tissue were collected from 199 (CRC) patients. was evaluated by FISH analysis, real-time RT-PCR, ELISA IHC. A polymorphism in promoter PCR analysis. levels different methods mutually compared. Seventy-eight percent of primary tumours lymph nodes had...
Abstract Objectives To identify molecular pathways and prognostic- diagnostic plasma-protein biomarkers for diabetic retinopathy at various stages. Methods This exploratory, cross-sectional proteomics study involved plasma from 68 adults, including 15 healthy controls 53 diabetes patients stages of retinopathy: non-diabetic retinopathy, non-proliferative proliferative macular edema. Plasma was incubated with peptide library beads eluted proteins were tryptic digested, analyzed by liquid...
Background and Objectives The two most common autoimmune encephalitides (AE), N -methyl-D-Aspartate receptor (NMDAR) Leucine-rich Glioma-Inactivated 1 (LGI1) encephalitis, have been known for more than a decade. Nevertheless, no well-established biomarkers to guide treatment or estimate prognosis exist. Neurofilament light chain (NfL) has become an unspecific screening marker of axonal damage in CNS diseases, proven useful as diagnostic disease activity neuroinflammatory diseases. Only...
Abstract Purpose: Dysfunction of the epidermal growth factor (EGF) complex is essential to and development many human tumors. Overexpression EGF receptor (EGFR) a characteristic finding in considerable number solid tumors often signalizes poor prognosis. There major disagreement among researchers about both frequency possible clinical importance EGFR overexpression ovarian cancer. The type III variant (EGFRvIII) mutant with deletion. Contrary wild-type, it constitutively active. EGFRvIII has...
Background: The purpose of this study was to determine the positive predictive value (PPV) serum human epidermal growth factor receptor-2 (HER-2) for monitoring women with breast cancer following diagnosis and treatment in a routine clinical setting.
High tumor expression of epidermal growth factor-like domain 7 (EGFL7) has been associated with a poor prognosis in colorectal cancer. The aim the current study was to investigate possible prognostic impact circulating EGFL7 (cir-EGFL7), combined single nucleotide polymorphism (SNP) analyses, patients metastatic cancer (mCRC) treated first line chemotherapy and bevacizumab. A total 88 were included. Serum collected prior treatment initiation, at evaluation after 3 weeks, progression....