A5040386957- Diabetes Treatment and Management
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Water Quality Monitoring Technologies
- Diabetes and associated disorders
- Growth Hormone and Insulin-like Growth Factors
- Bariatric Surgery and Outcomes
- Pharmacology and Obesity Treatment
- Nutritional Studies and Diet
- Metabolism and Genetic Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Dietary Effects on Health
- Neurological Disorders and Treatments
- Muscle activation and electromyography studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Motor Control and Adaptation
- Social and Educational Sciences
- GDF15 and Related Biomarkers
- Electrolyte and hormonal disorders
- Neurological and metabolic disorders
- Terrorism, Counterterrorism, and Political Violence
Steno Diabetes Centers
2023-2025
Copenhagen University Hospital
2022-2025
Frederiksberg Hospital
2023-2024
Bispebjerg Hospital
2019-2024
University of Virginia Health System
2022
Odense Municipality
2021
Capital Region of Denmark
2019
University of Copenhagen
2018-2019
Guy's Hospital
1970
IntroductionGlucagon receptor agonism is currently explored for the treatment of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). The effects glucagon may in part be mediated by increases circulating levels Fibroblast Growth Factor 21 (FGF21) Differentiation 15 (GDF15). effect on FGF21 GDF15 remains uncertain, especially context elevated insulin commonly observed diseases.MethodsWe investigated a single bolus continuous infusion plasma concentrations conditions...
Abstract Aim Time‐restricted eating (TRE) limits the time for food intake to typically 6–10 h/day without other dietary restrictions. The aim of RESET2 (the REStricted Eating Time in treatment type 2 diabetes) trial is investigate effects on glycaemic control (HbA 1c ) and feasibility a 1‐year TRE intervention individuals with overweight/obesity diabetes. present paper describe protocol trial. Methods randomised, controlled, parallel‐group, open‐label One hundred sixty diabetes >53...
When we walk in a challenging environment, use visual information to modify our gait and place feet carefully on the ground. Here, explored how central common drive ankle muscles changes relation visually guided foot placement. Sixteen healthy adults aged 23 ± 5 years participated study. Electromyography (EMG) from Soleus (Sol), medial Gastrocnemius (MG), distal proximal ends of Tibialis anterior (TA) electroencephalography (EEG) Cz were recorded while subjects walked motorized treadmill. A...
Cognitive impairment in type 2 diabetes is associated with cerebral glucose hypometabolism. Providing a substitute such as ketone bodies might restore metabolic balance glucose-compromised neurones and improve cognitive performance. We aimed to investigate if β-hydroxybutyrate (ketone body) infusion acutely affects performance, measured by neuropsychological test battery, patients diabetes.Randomised, placebo-controlled, double-blind cross-over trial.Eighteen received i.v. body...
Increased plasma levels of glucagon (hyperglucagonemia) promote diabetes development but are also observed in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). This may reflect hepatic resistance toward amino acid catabolism. A clinical test for measuring has not been validated. We evaluated our sensitivity (GLUSENTIC) test, which consists 2 study days: a injection and measurements acids an infusion mixed subsequent calculation the GLUSENTIC index (primary...
Glucagon is a key regulator of metabolism and used in the diagnostic neuroendocrine tumors. Accurate measurement glucagon requires both extreme sensitivity specificity since several peptides are derived from same proglucagon precursor encoding part sequence given that circulates picomolar concentrations. A sandwich ELISA was recently developed extensively evaluated; however, this method may not be accurate when measuring patients with an enhanced production proglucagon-derived as seen after...
Background & aimsWe evaluated the effect of weight loss induced by dietary carbohydrate restriction on health-related quality life (HRQoL) and cognition in type 2 diabetes (T2D).MethodsIn this randomised parallel trial, 72 adults with T2D overweight/obesity (mean ± SD, HbA1c: 57 8 mmol/mol BMI: 33 5 kg/m2) were randomly assigned to a carbohydrate-reduced high-protein diet (CRHP: C30E%-P30E%-F40E%) or conventional (CD: C50E%-P17E%-F33E%) for 6 weeks, targeting 6% loss. HRQoL was assessed from...
Although endemic to much of the global population, few studies have examined Helicobacter pylori (H. pylori) in US refugee populations. This study investigates prevalence H. infection and barriers treatment International Family Medicine Clinic (IFMC), a primary care clinic, central Virginia.We conducted chart review 188 patients IFMC who were referred for an test between January 1, 2019, December 31, 2020. Recorded measures included patient demographics, result, initial infection, completion...
A physiological feedback system exists between hepatocytes and the alpha cells, termed liver-alpha cell axis refers to relationship amino acid-stimulated glucagon secretion glucagon-stimulated acid catabolism. Several reports indicate that non-alcoholic fatty liver disease (NAFLD) disrupts axis, because of impaired receptor signaling (glucagon resistance). However, no experimental test assess resistance in humans. The objective was develop an determine sensitivity with respect glucose...
Two sisters, both microcephalic at birth and of low birthweight, are described. They severely mentally retarded dwarfed, have developed diabetes mellitus. Their teeth show enamel hypoplasia. Excessive quantities alanine were found in their urine, which was associated with high levels pyruvate lactate the blood.
Background COVID-19 is associated with subclinical myocardial injury. Exogenous ketone esters acutely improve left function in healthy participants and patients heart failure, but the effects have not been investigated previously hospitalized for COVID-19. Methods This a randomized placebo-controlled double-blind crossover study comparing single oral ester dose of 395 mg/kg placebo. Fasting were to either placebo morning afternoon or vice versa. Echocardiography was performed immediately...
Inhibitors of neprilysin improve glycemia in patients with heart failure and type 2 diabetes (T2D). The effect weight loss by diet, surgery, or pharmacotherapy on activity (NEPa) is unknown. We investigated circulating NEPa protein concentrations obesity, T2D, metabolic dysfunction-associated steatotic liver disease (MASLD), following bariatric GLP-1-receptor-agonist therapy. NEPa, but not protein, was enhanced MASLD. Notably, MASLD associated independently BMI HbA1c. decreased after surgery...
Glucagon is best known for its contribution to glucose regulation through activation of the glucagon receptor (GCGR), primarily located in liver. However, glucagon's impact on other organs may also contribute potent effects health and disease. Given that glucagon-based medicine entering arena anti-obesity drugs, elucidating extrahepatic actions are increased importance. It has been reported stimulate secretion arginine-vasopressin (AVP)/copeptin, growth hormone (GH) adrenocorticotrophic...
<p dir="ltr">Increased plasma levels of glucagon (hyperglucagonaemia) promote diabetes development but is also observed in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). This may reflect hepatic resistance towards amino acid catabolism. A clinical test for measuring has not been validated. We evaluated our sensitivity (GLUSENTIC) test, consisting two study days: a injection and measurements acids, an infusion mixed acids subsequent calculation the...
<p dir="ltr">Increased plasma levels of glucagon (hyperglucagonaemia) promote diabetes development but is also observed in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). This may reflect hepatic resistance towards amino acid catabolism. A clinical test for measuring has not been validated. We evaluated our sensitivity (GLUSENTIC) test, consisting two study days: a injection and measurements acids, an infusion mixed acids subsequent calculation the...
<p dir="ltr">Increased plasma levels of glucagon (hyperglucagonaemia) promote diabetes development but is also observed in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). This may reflect hepatic resistance towards amino acid catabolism. A clinical test for measuring has not been validated. We evaluated our sensitivity (GLUSENTIC) test, consisting two study days: a injection and measurements acids, an infusion mixed acids subsequent calculation the...