A5018061859- Diabetes Treatment and Management
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Neuropeptides and Animal Physiology
- Urinary Bladder and Prostate Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Peptidase Inhibition and Analysis
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Urinary Tract Infections Management
- Cardiovascular Health and Disease Prevention
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Gastroesophageal reflux and treatments
- Reproductive Biology and Fertility
University of Copenhagen
2008-2024
Copenhagen University Hospital
1984-2024
Bispebjerg Hospital
2013-2024
Frederiksberg Hospital
2003-2024
Steno Diabetes Centers
2000-2023
Odense Municipality
2020-2021
Aalborg University Hospital
1983-2015
Gentofte Hospital
2000-2011
Capital Region of Denmark
2003
Hvidovre Hospital
1979-2000
Incretin hormones importantly enhance postprandial insulin secretion but are rapidly degraded to inactive metabolites by ubiquitous dipeptidyl peptidase IV. The concentrations of the intact biologically active remain largely unknown. Using newly developed assays for glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP), we measured plasma after a mixed breakfast meal (566 kcal) in 12 type 2 diabetic patients (age 57 years [range 49–67], BMI 31 kg/m2 [27–38],...
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretin hormones secreted in response to meal ingestion, thereby enhancing postprandial insulin secretion. Therefore, an attenuated could contribute the impaired responses patients with diabetes mellitus. The aim of present investigation was investigate secretion, obesity type 1 2 mellitus, its dependence on magnitude stimulus. Plasma concentrations (total, reflecting secretion intact, potential...
iraglutide is a long-acting human glucagon-like peptide-1 (GLP-1) analog (1-4), and the current study was undertaken to evaluate efficacy safety after 14 weeks' treatment with liraglutide in patients type 2 diabetes. RESEARCH DESIGN AND METHODS -Main inclusion criteriawere aged Ն18 years diabetes A1C Ն7.5 Յ10.0% (diet) or Ն7.0 Յ9.5% (mono-oral antidiabetes drug); previous therapy discontinued.Fasting plasma glucose (FPG) at randomization 7-13 mmol/l.If FPG Ͼ15 mmol/l during study, patient...
We have previously shown that type 2 diabetic patients decreased plasma concentrations of glucagon-like peptide 1 (GLP-1) compared with healthy subjects after ingestion a standard mixed meal. This decrease could be caused by differences in the metabolism GLP-1. The objective this study was to examine pharmacokinetics GLP-1 and iv bolus doses ranging from 2.5-25 nmol/subject. Bolus injections 2.5, 5, 15, 25 nmol meal test were performed six [age, mean (range): 56 (48-67) yr; body mass index:...
We aimed to investigate whether the reduced incretin effect observed in patients with type 2 diabetes is a primary event pathogenesis of or consequence diabetic state. Eight chronic pancreatitis and secondary (A1C mean [range] 6.9% [6.2–8.0]), eight normal glucose tolerance (NGT; 5.3 [4.9–5.7]), (6.9 [6.2–8.0]); healthy subjects (5.5 [5.1–5.8]) were studied. Blood was sampled over 4 h on separate days after 50-g oral load an isoglycemic intravenous infusion, respectively. The (100% × [β-cell...
Male reproductive function seems to have deteriorated considerably during the past 4–5 decades. However, studies of in unselected populations not previously been reported. As large majority young men Denmark are subjected a compulsory medical examination for military service, this provided unique opportunity study an unbiased population. Altogether 891 delivered blood sample which hormones were measured. From 708 these data also obtained on semen quality and testis size. The median sperm...
Collagen type I fragments, reflecting bone resorption, and release of gut hormones were investigated after a meal. Investigations led to dose escalation study with glucagon like peptide-2 (GLP-2) in postmenopausal women. We found dose-dependent effect GLP-2 on the reduction resorption.The C-terminal telopeptide region collagen as measured serum (s-CTX) can be used assess resorption. This marker resorption has significant circadian variation that is influenced by food intake. However,...
Abstract The effect of the insulinotropic incretin hormone, glucagon-like peptide-1 (GLP-1), is preserved in typical middle-aged, obese, insulin-resistant type 2 diabetic patients, whereas a defective amplification so-called late-phase plasma insulin response (20–120 min) to glucose by other glucose-dependent polypeptide (GIP), seen these patients. aim present investigation was evaluate and C-peptide responses GLP-1 GIP five groups patients with etiology phenotype distinct from obese We...
Abstract Aims To assess the effect of liraglutide, a once‐daily human glucagon‐like peptide‐1 analogue on pancreatic B‐cell function. Methods Patients with Type 2 diabetes ( n = 39) were randomized to treatment 0.65, 1.25 or 1.9 mg/day liraglutide placebo for 14 weeks. First‐ and second‐phase insulin release measured by means insulin‐modified frequently sampled intravenous glucose tolerance test. Arginine‐stimulated secretion was during hyperglycaemic clamp (20 mmol/l). Glucose effectiveness...
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide are incretin hormones, secreted in response to meal ingestion. The hormones stimulate insulin secretion essential for the maintenance of normal plasma glucose concentrations. Both metabolized quickly by enzyme dipeptidyl peptidase-IV (DPP-IV). It is well known that type-2 diabetic patients have an impaired effect. Therefore, aim present study was investigate DPP-IV activity fasting postprandial state control...
People with type 2 diabetes mellitus (T2DM) are characterized by reduced incretin effect and inappropriate glucagon levels. We evaluated α β-cell responses to oral glucose tolerance test (OGTT) isoglycaemic intravenous infusion (IIGI) in lean obese persons T2DM or normal (NGT) elucidate the impact of obesity on hormone responses.Four hour 50-g OGTT IIGI were performed (i) Eight patients [mean body mass index (BMI): 37 (range: 35-41) kg/m(2)]; (ii) subjects NGT [BMI: 33 (35-38) (iii) 24...
In order to discriminate between insulin-dependent and non-insulin-dependent patients, serum C-peptide concentration was determined using antiserum M1230 in the fasting state 6 min after an i.v. injection of 1 mg glucagon 215 patients treated with insulin 53 diet oral antidiabetics. A patient considered well controlled without when blood glucose below 8 mmol/l glucosuria absent. After re-evaluation therapy hospital it found that majority a post-stimulatory above 0.60 pmol/ml appeared have...
The release of immunoreactive gastric inhibitory polypeptide (IR-GIP) in response to a standard meal was examined 10 normal subjects and 15 type I (insulin-dependent) diabetics 7 days (test I), 14 II), 3 months III) after time diagnosis. During all three tests, the had significantly lower plasma IR-GIP concentrations than controls from 15–90 min meal. measured as integrated area under curve corresponded 70% that subjects. β-cell function evaluated C-peptide increased test III whereas similar...
To investigate the effect of 4 weeks treatment with liraglutide on insulin dose and glycemic control in type 1 diabetic patients without residual β-cell function.Ten function (C-peptide positive) 19 negative) were studied. All C-peptide-positive treated plus insulin, whereas C-peptide-negative randomly assigned to or monotherapy. Continuous glucose monitoring identical food intake physical activity was performed before (week 0) during 4) treatment. Differences dose; HbA1c; time spent blood...
The role of preserved beta-cell function in preventing ketoacidosis type I insulin-dependent diabetes was assessed eight patients with and seven without residual as determined from C-peptide concentrations. After 12 hours insulin fatty-acid, glycerol concentrations were all significantly higher than those secretion. Mean blood glucose reached 17.2 +/- SE mean 1.3 mmol/l (310 23 mg/100 ml) the first group compared 8.8 1.4 (159 25 second (P less 0.01), while 3-hydroxybutyrate rose to 5.5 (57 5...