A5101446729- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Nutrition and Health in Aging
- Pancreatic function and diabetes
- Bariatric Surgery and Outcomes
- Erythrocyte Function and Pathophysiology
- Fibroblast Growth Factor Research
- T-cell and B-cell Immunology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Monoclonal and Polyclonal Antibodies Research
- Obesity and Health Practices
- GDF15 and Related Biomarkers
- Transgenic Plants and Applications
- Plant tissue culture and regeneration
- Blood groups and transfusion
- Amino Acid Enzymes and Metabolism
- Dietary Effects on Health
- Asthma and respiratory diseases
- CRISPR and Genetic Engineering
- Viral Infectious Diseases and Gene Expression in Insects
Copenhagen University Hospital
2018-2024
Bispebjerg Hospital
2018-2024
Hvidovre Hospital
2024
Frederiksberg Hospital
2023-2024
Odense Municipality
2020-2021
University of Copenhagen
2002
MS-Schramberg (Germany)
1994
Max Planck Institute of Immunobiology and Epigenetics
1988
Inserm
1984
Abstract Context Fibroblast growth factor 21 (FGF21) and differentiation 15 (GDF15) are increased in type 2 diabetes potential regulators of metabolism. The effect changes caloric intake macronutrient composition on their circulating levels patients with unknown. Objective To explore the effects a carbohydrate-reduced high-protein diet without clinically significant weight loss FGF21 GDF15 diabetes. Methods We measured who completed previously published interventions. Study 1 randomized 28...
Abstract. The effect of Tamm Horsfall protein (THP) 18 healthy subjects and 14 diabetics on adherence Escherichia coli (06:K13) 2699 strain to human kidney cells (HUK) was studied. Adhesion bacteria (without additions: 100 per cell) reduced dose‐dependently by THP, half maximal inhibition occurring with 250 μg THP ml ‐1 . Maximal (– 84% at 1000 ) exceeded alphamethyl‐mannoside (36% 50 mM), specific (not reproduced other glycoproteins, e.g. ovalbumin, mucin or thyroglobulin) reversible...
Dietary carbohydrate restriction may improve the phenotype of Type 2 diabetes (T2D) patients. We aimed to investigate 6 wk on postprandial glucose metabolism, pancreatic α- and β-cell function, gut hormone secretion, satiety in T2D Methods In a crossover design, 28 patients (mean HbA1c: 60 mmol/mol) were randomized carbohydrate-reduced high-protein (CRHP) diet conventional (CD) (energy-percentage carbohydrate/protein/fat: 30/30/40 vs. 50/17/33). Twenty-four-hour continuous monitoring (CGM)...
Postprandial responses to food are highly dependent on the macronutrient composition of diet. We investigated acute effects transition from recommended moderately high carbohydrate (HC) diet towards a carbohydrate-reduced high-protein (CRHP) postprandial glycemia, insulinemia, lipemia, and appetite-regulating hormones in non-diabetic adults. Fourteen subjects, including five males (Mean ± SD: age 62 6.5; BMI 32 7.6 kg/m2; hemoglobin A1c (HbA1c) 40 3.0 mmol/mol; HOMA2-IR 2.1 0.9) were...
Background & aimsWe evaluated the effect of weight loss induced by dietary carbohydrate restriction on health-related quality life (HRQoL) and cognition in type 2 diabetes (T2D).MethodsIn this randomised parallel trial, 72 adults with T2D overweight/obesity (mean ± SD, HbA1c: 57 8 mmol/mol BMI: 33 5 kg/m2) were randomly assigned to a carbohydrate-reduced high-protein diet (CRHP: C30E%-P30E%-F40E%) or conventional (CD: C50E%-P17E%-F33E%) for 6 weeks, targeting 6% loss. HRQoL was assessed from...
Hyperglucagonemia may develop in type 2 diabetes due to obesity-prone hepatic steatosis (glucagon resistance). Markers of glucagon resistance (including the glucagon-alanine index) improve following diet-induced weight loss, but partial contribution lowering vs body is unknown.This work aimed investigate dependency loss a reduction on markers diabetes.A post hoc analysis was conducted from previously published randomized controlled trials. We investigated effect maintenance (study 1:...
We previously observed beneficial effects of a carbohydrate-reduced, high-protein (CRHP) diet on cardiovascular risk markers in patients with type 2 diabetes mellitus (T2DM) crossover × 6-week trial, when all food was provided to subjects as ready-to-eat meals. Here, we report the results from 6-month open label extension: 28 T2DM were instructed self-prepare CRHP dietetic guidance. At weeks 0, 6, 12, and 36, fasting postprandial (4-h meal test) blood samples collected for measurements...
Carbohydrate restriction may benefit β-cell function and glucose metabolism in type 2 diabetes (T2D) but also leads to weight loss which itself is beneficial.In order determine the additional effect of carbohydrate addition a fixed body loss, we randomly assigned 72 adults with T2D obesity (mean ± SD HbA1c 7.4 0.7%, BMI 33 5 kg/m2) carbohydrate-reduced high-protein diet (CRHP; energy percent from carbohydrate/protein/fat: 30/30/40) or an isocaloric conventional (CD; 50/17/33) for 6 weeks....
A fully provided, hypocaloric, carbohydrate-reduced high-protein (CRHP) diet compared to a hypocaloric conventional diabetes (CD) for 6 weeks improved glycemic control greater extent in face of an intended 6% weight loss individuals with type 2 mellitus (T2DM). The present 24-week extension that study reports on the efficacy CRHP and CD diets real-life setting. Sixty-five T2DM who completed initial 6-week provided period (% energy from carbohydrate, protein, fat was 30/30/40 CRHP, 50/17/33...
The cornerstone in the management of type 2 diabetes (T2D) is lifestyle modification including a healthy diet, typically one which carbohydrate provides 45%-60% total energy intake (E%). Nevertheless, systematic reviews and meta-analyses trials with low diets (which are increased protein and/or fat) for T2D have found improved glycaemic control first months relative to comparator higher content. Studies lasting ≥1 year inconclusive, could be due decreased long-term dietary adherence. We...
Objective: Elevated triglyceride-rich lipoproteins (TRL), excess small dense LDL particles (LDL5) and decreased HDL2/HDL3 ratio promote atherogenesis in type 2 diabetes (T2D). Carbohydrate restriction reduced intrahepatic triglyceride (IHTG) content beyond the positive effect of weight loss a group T2D patients, present study sought to determine whether parallel improvements lipoprotein density profiles occurred these same patients. Research Design Methods: Seventy-two adult patients with...
Background: We hypothesized that dietary carbohydrate reduction will add to the effect of a diet-induced 6% body-weight loss on glycemic control and hepatic fat content in patients with type 2 diabetes (T2D). Methods: Forty-four persons mean HbA1c 56.4 mmol/mol 9 years T2D were randomized 1:1 for 6-weeks full food provision, hypo-caloric carbohydrate-reduced high-protein (CRHP) or conventional (CD) diet (carbohydrate 30E%/50E%, protein 30E%/17E% 40E%/33E%). Body-weight was aimed at...
Objective: We aimed to evaluate the effect of weight loss induced by a carbohydrate-reduced high-protein (CRHP) diet on physical and mental health cognition.Methods: In this randomized parallel trial, 72 adults with type 2 diabetes overweight or obesity (mean±SD, HbA1c: 7.4±0.7% BMI: 33±5 kg/m2) were randomly assigned CRHP (C30E%/P30E%/F40E%) control (CD: C50E%/P17E%/F33E%) for 6 weeks. The two diets intended induce similar losses (~6%). Physical component summary (PCS MCS) scores assessed...