A5085065352- Plant and animal studies
- Ecology and Vegetation Dynamics Studies
- Pharmacogenetics and Drug Metabolism
- Plant Parasitism and Resistance
- Drug-Induced Hepatotoxicity and Protection
- Metabolism and Genetic Disorders
- Species Distribution and Climate Change
- Liver Disease Diagnosis and Treatment
- Pharmaceutical Practices and Patient Outcomes
- Drug Transport and Resistance Mechanisms
- Pelvic floor disorders treatments
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Neonatal Health and Biochemistry
- Diet and metabolism studies
- Liver Disease and Transplantation
- Urinary Tract Infections Management
- Urinary Bladder and Prostate Research
- Analytical Methods in Pharmaceuticals
- Blood Pressure and Hypertension Studies
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Hepatitis C virus research
- Acute Lymphoblastic Leukemia research
- Infectious Encephalopathies and Encephalitis
Bispebjerg Hospital
1986-2024
Nordic Bioscience (Denmark)
2024
Merck (Germany)
2024
Sage Therapeutics (United States)
2024
University of Copenhagen
2014-2024
Frederiksberg Hospital
2016-2024
Copenhagen University Hospital
2002-2024
Natural History Museum Aarhus
2014-2019
Gentofte Hospital
1999-2015
Massachusetts Institute of Technology
2014
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretin hormones secreted in response to meal ingestion, thereby enhancing postprandial insulin secretion. Therefore, an attenuated could contribute the impaired responses patients with diabetes mellitus. The aim of present investigation was investigate secretion, obesity type 1 2 mellitus, its dependence on magnitude stimulus. Plasma concentrations (total, reflecting secretion intact, potential...
Latitudinal patterns of biodiversity have been studied for centuries, but it is only during the last decades that species interaction networks used to examine proposed latitudinal gradient biotic specialization. These studies given idiosyncratic results, which may either be because genuine biological differences between systems, different concepts and scales quantify specialization or methodological approaches compare were inappropriate. Here we carefully using a global dataset avian...
Background: The relative frequency of wind- and animal-pollinated plants a non-randomly distributed across the globe numerous hypotheses have been raised for greater occurrence wind pollination in some habitats towards higher latitudes. To date, however, there has no comprehensive global investigation these hypotheses.Aims: Investigating range role biotic abiotic factors as determinants variation animal vs. pollination.Methods: We analysed 67 plant communities ranging from 70º north to 34º...
Interactions between species are influenced by different ecological mechanisms, such as morphological matching, phenological overlap and abundances. How these mechanisms explain interaction frequencies across environmental gradients remains poorly understood. Consequently, we also know little about the that drive geographical patterns in network structure, complementary specialization modularity. Here, use data on morphologies, phenologies abundances to hummingbirds plants at a large scale....
Abstract Functional traits can determine pairwise species interactions, such as those between plants and pollinators. However, the effects of biogeography evolutionary history on trait‐matching trait‐mediated resource specialization remain poorly understood. We compiled a database 93 mutualistic hummingbird–plant networks (including 181 hummingbird 1,256 plant species), complemented by morphological measures bill floral corolla length. divided hummingbirds into their principal clades used...
Tropical mountains are global biodiversity hotspots, owing to a combination of high local species richness and turnover in composition. Typically, the highest levels implicitly assumed converge same mountain regions, resulting extraordinary at regional scales. We investigated this untested assumption using high-resolution distribution data for all 9,788 bird found 134 regions worldwide. Contrary expectations, with differed from those turnover. This finding reflects dissimilarities regions’...
Objective To assess the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of single multiple injections M6495, a disintegrin metalloproteinase with thrombospondin motifs 5 (ADAMTS‐5) nanobody, in healthy volunteers patients osteoarthritis. Methods Two randomized, placebo‐controlled, double‐blind studies were performed. Study 1 enrolled 54 male who received one subcutaneous (s.c.) injection M6495 (1‐300 mg) or placebo (ratio 2:1), evaluating PK, PD as changes serum aggrecan fragment...
Abstract Aim To investigate the role of alien plants in mutualistic plant–hummingbird networks, assessing importance species traits, floral abundance and insularity on plant integration. Location Mainland insular Americas. Methods We used species‐level network indices to assess 21 quantitative networks where occur. then evaluated whether including previous adaptations bird pollination, predict these roles. Additionally, for a subset which data were available, we tested this relates Finally,...
Abstract Aim Species interaction networks are known to vary in structure over large spatial scales. We investigated the hypothesis that environmental factors affect network by influencing functional diversity of ecological communities. Notably, we expect more functionally diverse communities form with a higher degree niche partitioning. Location: Americas. Time period: Current. Major taxa studied: Hummingbirds and their nectar plants. Methods used dataset comprising 74 quantitative...
Abundant pollinators are often more generalised than rare pollinators. This could be because abundant species have chance encounters with potential interaction partners. On the other hand, a competitive advantage over specialists, leading to higher abundance. Determining direction of abundance–generalisation relationship is therefore ‘chicken‐and‐egg’ dilemma. Here we determine between abundance and generalisation in plant–hummingbird pollination networks across Americas. We find evidence...
Abstract Morphological trait matching between species affects resource partitioning in mutualistic systems. Yet, the determinants of spatial variation remain largely unaddressed. Here, we generate a hypothesis that is based on geographical distributions morphologies. To illustrate our hypothesis, as study system use hummingbirds tropical Andes. Hummingbirds with specialized morphologies (i.e., long or curved bills) may forage flowers are inaccessible to generalized bill small‐to‐medium‐sized...
Background Peptide-based vaccination is a rational option for immunotherapy of prostate cancer. In this first-in-man phase I/II study, we assessed the safety, tolerability and immunological impact synthetic long peptide vaccine targeting Ras homolog gene family member C (RhoC) in patients with RhoC small GTPase overexpressed advanced solid cancers, metastases cancer stem cells. Methods Twenty-two who had previously undergone radical prostatectomy received subcutaneous injections 0.1 mg...
Animal pollinators are globally threatened by anthropogenic land use change and agricultural intensification. The yield of many food crops is therefore negatively impacted because they benefit from biotic pollination. This especially the case in tropics. For instance, fruit set Coffea arabica has been shown to increase 10–30% plantations with a high richness bee species, possibly influenced availability surrounding forest habitat. Here, we performed global literature review (1) assess how...
The immense concentrations of vertebrate species in tropical mountains remain a prominent but unexplained pattern biogeography. A long-standing hypothesis suggests that montane biodiversity hotspots result from endemic aggregating within ecologically stable localities. Here, the persistence ancient lineages coincides with frequent speciation events, making such areas both 'cradles' (where new arise) and 'museums' old survive). Although this refers to processes operating at scale valleys, it...
Antipyrine clearance was estimated by a one-sample technique in 14 patients with acute fever and clinical pneumonia. during the illness 31.4 ± 7.6 ml/min (X SD). Fourteen 28 days later convalescence, values were higher (47.8 18.9 49.2 15.0 ml/ min, respectively). We conclude that microsomal hepatic drug metabolism adults is impaired Clinical Pharmacology Therapeutics (1985) 37, 701–704; doi:10.1038/clpt.1985.117
Island biogeography has greatly contributed to our understanding of the processes determining species' distributions. Previous research focused on effects island geography (i.e., area, elevation, and isolation) current climate as drivers species richness endemism. Here, we evaluate potential additional historical breeding land bird endemism in Wallacea West Indies. Furthermore, basis distributions, identify biogeographical network roles examine their association with geography, climate,...
Ecological communities that experience stable climate conditions have been speculated to preserve more specialized interspecific associations and higher proportions of smaller ranged species (SRS). Thus, areas with disproportionally large numbers SRS are expected coincide geographically a high degree community-level ecological specialization, but this suggestion remains poorly supported empirical evidence. Here, we analysed data for hummingbird resource range size, contemporary climate, Late...
Aims Grapefruit juice inhibits CYP3A4 in the intestinal wall leading to a reduced first pass metabolism and thereby an increased oral bioavailability of certain drugs. For example, it has been shown that midazolam, substrate, by 52% healthy subjects after ingestion grapefruit juice. However, this interaction not studied patients with impaired liver function. Accordingly, effect on AUC midazolam metabolite α‐hydroxymidazolam was cirrhosis liver. Methods An open randomized two‐way crossover...
Objective Our objective was to investigate the effect of acute hypoxia on activity hepatic cytochrome P450 (CYP) enzymes. Methods Twelve healthy subjects who lived at sea level were exposed altitude‐induced for 7 days 4559 m above level. Hepatic CYP enzyme measured before departure, 24 and 96 hours after arrival high‐altitude location, 1 month return activities by means metabolic ratios sparteine (CYP2D6), endogenous cortisol metabolism (CYP3A4), caffeine (CYP1A2), as well S/R ratio...