A5002442735- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Sympathectomy and Hyperhidrosis Treatments
- Biosimilars and Bioanalytical Methods
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer Treatment and Pharmacology
- Pharmacological Effects and Toxicity Studies
- Drug-Induced Hepatotoxicity and Protection
- Metabolomics and Mass Spectrometry Studies
- Drug-Induced Adverse Reactions
- HER2/EGFR in Cancer Research
- Migraine and Headache Studies
- Atrial Fibrillation Management and Outcomes
- Glaucoma and retinal disorders
- Statistical Methods in Clinical Trials
- Glioma Diagnosis and Treatment
- Antifungal resistance and susceptibility
University of Southern Denmark
2020-2024
Odense University Hospital
2020
Paclitaxel-induced peripheral neuropathy (PIPN) is a barrier to effective cancer treatment and impacts quality of life among patients with cancer. We used translational approach assess the utility neurofilament light chain (NFL) as biomarker PIPN in human cell model ovarian measured NFL medium from induced pluripotent stem cell-derived sensory neurons (iPSC-SNs) exposed paclitaxel. Serum (sNFL) levels were quantified 190 receiving paclitaxel/carboplatin chemotherapy at baseline after each...
Abstract Pharmacokinetics is the cornerstone of understanding drug absorption, distribution, metabolism, and elimination. It also key to describing variability in response caused by drug‐drug interactions (DDIs), pharmacogenetics, impaired kidney liver function, etc. This tutorial aims provide a guideline step‐by‐step on essential considerations when designing clinical pharmacokinetic studies reporting results. includes comprehensive guide how conduct statistical analysis complete code for...
Flucloxacillin is a widely used antibiotic. It an agonist to the nuclear receptor PXR that regulates expression of cytochrome P450 (CYP) enzymes. Treatment with flucloxacillin reduces warfarin efficacy and plasma concentrations tacrolimus, voriconazole, repaglinide. We conducted translational study investigate if induces CYP also investigated its own metabolism as autoinducer. performed randomized, unblinded, two‐period, cross‐over, clinical pharmacokinetic cocktail study. Twelve healthy...
We aimed to assess if dicloxacillin/flucloxacillin reduces the therapeutic efficacy of direct oral anticoagulants (DOACs) and underlying molecular mechanism.
Background This study aims to assess the migraine-inducing effects of sildenafil in men with migraine without aura. While has been shown provoke women, its effect on remains unknown. Methods The trial will enroll 12 and 15 all diagnosed participate a randomized, placebo-controlled crossover women an open-label study. Participants be monitored for attacks associated symptoms h post-administration. primary endpoints include incidence sildenafil-treated compared placebo between women. Secondary...