A5023072692- Renal Transplantation Outcomes and Treatments
- Cancer Treatment and Pharmacology
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Colorectal Cancer Treatments and Studies
- Drug Transport and Resistance Mechanisms
- HIV/AIDS drug development and treatment
- Neurological Complications and Syndromes
- Biochemical and Molecular Research
- Organ Transplantation Techniques and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Patient Safety and Medication Errors
- Animal testing and alternatives
- Pancreatic and Hepatic Oncology Research
- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- HER2/EGFR in Cancer Research
- Pregnancy and Medication Impact
- Hematopoietic Stem Cell Transplantation
- Ovarian cancer diagnosis and treatment
- Pain Management and Opioid Use
- Clinical Reasoning and Diagnostic Skills
- Statistical Methods in Clinical Trials
- Pharmacology and Obesity Treatment
Odense University Hospital
2015-2024
University of Southern Denmark
2012-2024
Hospital South West Jutland
2016-2023
Aarhus University Hospital
2014-2016
The University of Queensland
2011-2015
Aarhus University
2013
Karolinska Institutet
2004
Inconsistencies in the reproducibility of research findings are pertinent concern throughout scientific community. The disclosure an apparent and low degree has fuelled investigations causal factors, ranging from behavioural preferences decision-making/"human nature" conviction bias to experimental constituents.1-3 increased awareness identified several aspects data collection, analysis subsequent interpretation be carefully considered, a range preventive measures considerations been...
Inconsistencies in the reproducibility of research findings are pertinent concern throughout scientific community. Initially addressed pre-clinical biomedicine studies 1, 2, discussion has expanded to fields outside natural sciences, questioning reliability data and subsequent published findings, proposing a ‘Crisis Confidence’ or ‘Reproducibility Crisis’ within several (if not all) areas 2-6. The disclosure an apparent low degree fuelled investigations causal factors, ranging from...
The manuscript is an updated version of the previously published "BCPT policy for experimental and clinical studies" from 2021.
Abstract Clonidine is an α‐adrenoceptor agonist acting on receptors in the brain and peripheral tissues, leading to a reduction sympathetic outflow release of certain neurotransmitters. has multiple uses across various medical conditions. One its as adjuvant anaesthetic analgesic agents specially opioids, mostly administered through intravenous epidural routes. The effective cancer pain management, are associated with side effects such sedation, pruritus, constipation, nausea, respiratory...
Objectives: The aims of this study were to develop a population pharmacokinetic model tacrolimus in adult kidney transplant recipients, use compare cytochrome P450 3A5 (CYP3A5) genotype–based initial dosing with standard per-kilogram–based dosing, and predict the best starting dose based on patient genotype achieve trough concentration between 6 10 µg/L by day 5 posttransplantation. Methods: Population analysis was performed using software program NONMEM. Tacrolimus regimens compared...
The aim was to develop a theory-based population pharmacokinetic model of tacrolimus in adult kidney transplant recipients and externally evaluate this two previous empirical models.Data were obtained from 242 patients with 3100 whole blood concentrations. External evaluation performed by examining predictive performance using Bayesian forecasting.Pharmacokinetic disposition parameters estimated based on plasma concentrations, predicted haematocrit literature values for binding red cells....
Paclitaxel-induced peripheral neuropathy (PIPN) is a barrier to effective cancer treatment and impacts quality of life among patients with cancer. We used translational approach assess the utility neurofilament light chain (NFL) as biomarker PIPN in human cell model ovarian measured NFL medium from induced pluripotent stem cell-derived sensory neurons (iPSC-SNs) exposed paclitaxel. Serum (sNFL) levels were quantified 190 receiving paclitaxel/carboplatin chemotherapy at baseline after each...
Background. Docetaxel is a highly effective treatment of wide range malignancies but often associated with peripheral neuropathy. The genetic variability genes involved in the transportation or metabolism docetaxel may be responsible for variation docetaxel-induced neuropathy (DIPN). main purpose this study was to investigate impact variants GSTP1 and ABCB1 on DIPN.Material methods. DNA extracted from whole blood 150 patients early-stage breast cancer who had received adjuvant February 2011...
Pregnane X, encoded by the gene NR112, is a nuclear receptor whose primary role to promote detoxification and clearance of drugs other foreign compounds from body.The aim this study was analyze associations between NR1I2 polymorphisms, immunosuppressant drug exposure, clinical outcomes in adult kidney transplant recipients.Exposures tacrolimus, mycophenolic acid, total free prednisolone were estimated at month 1 posttransplant using validated multiple regression-derived limited sampling...
The authors state no conflicts of interest. Data S1. Supporting Information S2. S3. S4. Please note: publisher is not responsible for the content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.
The standard treatment for ovarian cancer in advanced stages is post-surgery with taxane-platin chemotherapy. Despite an initial high response rate, most patients eventually relapse. dose-limiting toxicities of paclitaxel are neutropenia and neuropathy, but the inter-individual variability large. aim this prospective study was to investigate impact genetic variants key drug metabolizing/transporter genes on toxicity compliance. CYP2C8*3 three ABCB1 polymorphisms were chosen primary analysis,...
Paclitaxel is mainly eliminated by CYP2C8 in the liver. strongly inhibited clopidogrel metabolite acyl‐β‐D‐glucuronide. To determine if this interaction has clinical relevance, we identified 48 patients treated with and paclitaxel using databases a prescription register. Peripheral sensory neuropathy was retrospectively evaluated from medical charts compared to that of 88 age‐ sex‐matched controls low‐dose aspirin. By cumulative dose 1,500 mg paclitaxel, 35% had developed severe neuropathy....
The aim of the present case report was to describe a novel pharmacokinetic drug–drug interaction between antiplatelet agent clopidogrel and antineoplastic paclitaxel.The patient identified in previously described cohort 93 patients with ovarian carcinoma treated paclitaxel. effect acyl-β-D-glucuronide on metabolism paclitaxel assessed human liver microsomes. analysis plasma quantification 6-hydroxypaclitaxel vitro samples were performed by liquid chromatography tandem mass spectrometry.The...