A5059094861- Cancer Treatment and Pharmacology
- Glioma Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Microtubule and mitosis dynamics
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Educational and Psychological Assessments
- Multiple Myeloma Research and Treatments
- Hormonal Regulation and Hypertension
- Statistical Methods in Clinical Trials
- Metabolomics and Mass Spectrometry Studies
- Interprofessional Education and Collaboration
- HER2/EGFR in Cancer Research
- Probiotics and Fermented Foods
- Language Development and Disorders
- Cancer therapeutics and mechanisms
- Microbial Inactivation Methods
- Cancer, Hypoxia, and Metabolism
- Health, Nursing, Elderly Care
- Family and Disability Support Research
- Identification and Quantification in Food
- Health Systems, Economic Evaluations, Quality of Life
- CAR-T cell therapy research
- Virus-based gene therapy research
University of Southern Denmark
2020-2025
Institut für Medien- und Kommunikationspolitik
2012
University of Copenhagen
2010
Paclitaxel-induced peripheral neuropathy (PIPN) is a barrier to effective cancer treatment and impacts quality of life among patients with cancer. We used translational approach assess the utility neurofilament light chain (NFL) as biomarker PIPN in human cell model ovarian measured NFL medium from induced pluripotent stem cell-derived sensory neurons (iPSC-SNs) exposed paclitaxel. Serum (sNFL) levels were quantified 190 receiving paclitaxel/carboplatin chemotherapy at baseline after each...
Recent evidence suggests that atorvastatin exacerbates paclitaxel neurotoxicity via P-glycoprotein inhibition. We used a translational approach to investigate if or simvastatin (i) in human sensory neurons and (ii) paclitaxel-induced peripheral neuropathy (PIPN) cancer patients. Paclitaxel was assessed by quantifying neuronal networks of induced pluripotent stem cell-derived (iPSC-SNs) with without exposure. estimated the odds ratio (OR) early discontinuation due PIPN nationwide cohort...
Paclitaxel‐induced peripheral neuropathy (PIPN) is a common and dose‐limiting adverse event. The role of P‐glycoprotein (P‐gp) in the neuronal efflux paclitaxel was assessed using translational approach. SH‐SY5Y cells were differentiated to neurons toxicity absence presence P‐gp inhibitor determined. Paclitaxel caused marked dose‐dependent SH‐SY5Y‐derived neurons. neurotoxicity exacerbated with concomitant inhibition by valspodar verapamil, consistent increased intracellular accumulation...
and Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) constitutes a significant health problem due to the increasing prevalence lack of therapies for treatment prevention. While pivotal routine cancer treatment, paclitaxel vincristine frequently cause CIPN impact quality life among patients survivors. Here, we investigate molecular mechanisms drug transport in CIPN.
Abstract Pharmacokinetics is the cornerstone of understanding drug absorption, distribution, metabolism, and elimination. It also key to describing variability in response caused by drug‐drug interactions (DDIs), pharmacogenetics, impaired kidney liver function, etc. This tutorial aims provide a guideline step‐by‐step on essential considerations when designing clinical pharmacokinetic studies reporting results. includes comprehensive guide how conduct statistical analysis complete code for...
The Danish Multiple Sclerosis Society initiated a large-scale bridge building and integrative treatment project to take place from 2004–2010 at specialized (MS) hospital. In this project, team of five conventional health care practitioners alternative was set up work together in developing offering individualized treatments 200 people with MS. purpose paper is present results the six year collaboration process regarding development an model. collaborative towards model for MS, involved...
Introduction: Recombinant human ACE2 increases the circulating levels of angiotensin-(1–5) [Ang-(1–5)], a peptide thus far regarded as biologically inactive. Since is central component protective RAS, we hypothesized that Ang-(1–5) new active within this hormonal system. Objective: To investigate biological activity and signaling mechanisms Ang-(1–5). Methods: In order to show effect test whether signals through AT 2 -receptor (AT R), nitric oxide (NO) release was measured by DAF-FM...
Abstract Chemotherapy-induced peripheral neuropathy (CIPN) constitutes a significant health problem due to the increasing prevalence and lack of therapies for treatment prevention. Patients with CIPN primarily present sensory symptoms, such as disturbances that may progress neuropathic pain in hands feet. While pivotal routine cancer treatment, paclitaxel vincristine frequently cause impact quality life among patients survivors. We utilized model human neurons derived from induced...
The angiotensin AT2 -receptor (AT2 R) is a key component within the protective arm of renin-angiotensin system inducing vasodilation by nitric oxide (NO) production. Currently, no high-throughput assay available to identify R agonists in vitro, which could explain low number selective ligands drug development programs.To design and validate method for detection activation vitro based on NO release.Human aortic endothelial cells (HAEC) were seeded into 96-well plates at density 5000 per well....
Introduction: Recombinant human ACE2 increases the circulating levels of angiotensin-(1-5) [Ang-(1-5)], a peptide thus far regarded as biologically inactive. Since is central component protective RAS, we hypothesized that Ang-(1-5) new active within this hormonal system. Objective: To investigate biological activity and signaling mechanisms Ang-(1-5). Methods: In order to show effect test whether signals through AT 2 -receptor (AT R), nitric oxide (NO) release was measured by DAF-FM...
The angiotensin AT2-receptor (AT2R) is a key component within the protective arm of renin-angiotensin system (RAS), being involved in nitric oxide (NO) production and vasodilation. To this date, no quantitative high-throughput assay available to identify AT2R agonists vitro , which may be reason for low number selective ligands drug development programs. Objective: design validate method detection activation . Methods Results: NO release was selected as readout transfected (CHO-AT2)...