A5023434070- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Drug-Induced Hepatotoxicity and Protection
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Folate and B Vitamins Research
- Atrial Fibrillation Management and Outcomes
- Pharmacovigilance and Adverse Drug Reactions
- Lipoproteins and Cardiovascular Health
- Restless Legs Syndrome Research
- Sex and Gender in Healthcare
- Pharmaceutical Practices and Patient Outcomes
- Diversity and Career in Medicine
- Health and Medical Research Impacts
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Parkinson's Disease Mechanisms and Treatments
- Rheumatoid Arthritis Research and Therapies
- Sleep and Wakefulness Research
- Statistical Methods in Clinical Trials
- Biosimilars and Bioanalytical Methods
Odense University Hospital
2019-2024
University of Southern Denmark
2021-2024
Abstract Pharmacokinetics is the cornerstone of understanding drug absorption, distribution, metabolism, and elimination. It also key to describing variability in response caused by drug‐drug interactions (DDIs), pharmacogenetics, impaired kidney liver function, etc. This tutorial aims provide a guideline step‐by‐step on essential considerations when designing clinical pharmacokinetic studies reporting results. includes comprehensive guide how conduct statistical analysis complete code for...
Flucloxacillin is a widely used antibiotic. It an agonist to the nuclear receptor PXR that regulates expression of cytochrome P450 (CYP) enzymes. Treatment with flucloxacillin reduces warfarin efficacy and plasma concentrations tacrolimus, voriconazole, repaglinide. We conducted translational study investigate if induces CYP also investigated its own metabolism as autoinducer. performed randomized, unblinded, two‐period, cross‐over, clinical pharmacokinetic cocktail study. Twelve healthy...
We aimed to assess if dicloxacillin/flucloxacillin reduces the therapeutic efficacy of direct oral anticoagulants (DOACs) and underlying molecular mechanism.
Drug metabolism might be altered in patients with type 2 diabetes. We aimed to evaluate if initiation of glucose-lowering drugs impacts warfarin efficacy and drug metabolism.First, we conducted a register-based self-controlled cohort study on Danish Scottish users. Warfarin (international normalized ratio [INR]) was compared before after drugs. Second, clinical pharmacokinetic trial comprising treatment-naïve diabetes patients. Patients ingested probe for drug-metabolizing enzymes (the Basel...
Aims Dicloxacillin is used to treat staphylococcal infections and we have previously shown that dicloxacillin an inducer of cytochrome P450 enzymes (CYPs). Here, employed a translational approach investigate the effect treatment with on warfarin efficacy in Danish registries. Furthermore, assessed as CYPs vitro. Methods We conducted register‐based study analysed international normalized ratio (INR) levels chronic users before after short‐ long‐term use ( n = 1023) flucloxacillin 123)....
<sec> <title>BACKGROUND</title> Collaborative care interventions have been proposed as a promising strategy to support patients with multimorbidity. Despite this, the effectiveness of collaborative requires further evaluation. Existing systematic reviews describing in multimorbidity management tend focus on specific interventions, patient subgroups, and settings. This necessitates comprehensive review that will provide an overview for adult </sec> <title>OBJECTIVE</title> aims systematically...
Collaborative care interventions have been proposed as a promising strategy to support patients with multimorbidity. Despite this, the effectiveness of collaborative requires further evaluation. Existing systematic reviews describing in multimorbidity management tend focus on specific interventions, patient subgroups, and settings. This necessitates comprehensive review that will provide an overview for adult
Abstract Background Inflammation suppresses cytochrome P450 (CYP) enzyme activity, and single-dose interleukin 6 receptor antagonists (anti-IL-6R) reverse this effect. Here, we assess the impact of continuous anti-IL-6R therapy in patients with rheumatoid arthritis. Methods In a clinical pharmacokinetic trial, Basel cocktail was administered before after 3 12 weeks to CYP activity (registered ClinicalTrials.gov database (identifier NCT04842981) on April 13 th , 2021) . retrospective study,...
ABSTRACT Drug metabolism might be altered in patients with type 2 diabetes. We aimed to evaluate if initiation of glucose-lowering drugs impacts warfarin efficacy and drug metabolism. First, we conducted a register-based self-controlled cohort study on Danish Scottish users. Warfarin (International Normalized Ratio (INR)) was compared before after drugs. Second, clinical pharmacokinetic trial comprising treatment-naïve diabetes patients. Patients ingested probe for drug-metabolizing enzymes...