A5069491403- Bone health and osteoporosis research
- Hip and Femur Fractures
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Pregnancy and Medication Impact
- Pelvic and Acetabular Injuries
- Retinoids in leukemia and cellular processes
- Dermatology and Skin Diseases
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects and Toxicity Studies
- Bone health and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Reproductive Health and Contraception
- Gastroesophageal reflux and treatments
- Allergic Rhinitis and Sensitization
- Vitamin D Research Studies
- HER2/EGFR in Cancer Research
- Herbal Medicine Research Studies
- Natural Products and Biological Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Pregnancy and preeclampsia studies
- Adrenal Hormones and Disorders
- Neurosurgical Procedures and Complications
- Hemodynamic Monitoring and Therapy
- Animal Diversity and Health Studies
Utrecht University
2019-2025
University Medical Center Utrecht
2024
American Society of Safety Professionals
2023
Maastricht University Medical Centre
2017-2022
Maastricht University
2018-2022
Pharmo Institute
2019-2021
Pharmac
2020
Cardiovascular Institute Hospital
2020
Weatherford College
2018
University of Regina
2018
We examined the effect of cumulative exposure to high doses oral glucocorticoids on fracture risk. Compared short-course users (daily dose ≥ 15 mg + < 1 g), heavy g) had highest risk fracture. These patients should be monitored for management strategies. The daily remains debated. therefore aimed examine hip associated with short courses and use high-dosed glucocorticoids. conducted a population-based case-control study using Danish National Health Service data, 1996–2011. Cases were those...
Patients with rheumatoid arthritis (RA) commonly use oral glucocorticoids (GCs) and proton pump inhibitors (PPIs), both associated osteoporotic fractures. We investigated the association between concomitant of GCs PPIs risk fractures among patients RA.This was a cohort study including RA aged 50+ years from Clinical Practice Research Datalink 1997 2017. Exposure to stratified by most recent prescription as current (<6 months), (7-12 months) past (>1 year); average daily cumulative dose;...
Due to established teratogenicity of valproates, the EU risk minimisation measures (RMMs) with a pregnancy prevention programme (PPP) for valproate were updated in March 2018.To investigate effectiveness 2018 RMMs on utilisation five European countries/regions.A multi-database, times series study females childbearing potential (12-55 years) was conducted using electronic medical records from countries/regions (01.01.2010-31.12.2020): Denmark, Tuscany (Italy), Spain, Netherlands, and UK....
Abstract Aneurysmal subarachnoid haemorrhage (aSAH) is a type of stroke with high mortality and morbidity. This study aimed to identify novel aSAH risk factors by combining machine learning (ML) traditional statistical methods. Using the UK Biobank, we identified cases via hospital-based ICD codes analysed 618 baseline variables covering demographics, lifestyle, medical history, physical measurements. The CatBoost ML algorithm Shapley Additive Explanations (SHAP) top 25 most influential in...
We investigated the incidence trend in all major osteoporotic fractures for whole country of Denmark between 1995 and 2010. Hip other declined general population especially among women. But, we observed some increasing men which needs more attention. The is varied across globe, there no updated information case (MOF). Thus, rates (IRs) MOF 50+ adults over period 1995–2010. A series cross-sectional analyses was done using Danish National Health Service Register. Participants were full with a...
Clinical trials have shown that low-dose glucocorticoid therapy in patients with RA reduces bone loss hands or hip, but the effect on osteoporotic fractures is not yet clear. Therefore, we investigated use of oral glucocorticoids and risk among RA.
In 2021, thrombosis with thrombocytopenia syndrome (TTS) was confirmed by the European Medicines Agency (EMA) as a rare side effect of COVID-19 adenovirus vector vaccines Vaxzevria® and Jcovden®. This study aimed to describe public's knowledge TTS how it affected willingness be vaccinated other in six countries. From June October 2022, multi-country cross-sectional online survey conducted Denmark, Greece, Latvia, Netherlands, Portugal, Slovenia. The minimum target participants recruited...
Current benefits of invasive intracranial aneurysm treatment to prevent aneurysmal subarachnoid hemorrhage (aSAH) rarely outweigh risks. Most aneurysms thus remain untreated. Commonly prescribed drugs reducing aSAH incidence may provide leads for drug repurposing. We performed a drug-wide association study (DWAS) systematically investigate the between commonly and incidence.
We aimed to assess if dicloxacillin/flucloxacillin reduces the therapeutic efficacy of direct oral anticoagulants (DOACs) and underlying molecular mechanism.
The European Medicines Agency (EMA) issued regulatory actions and communications in 2021 on thrombosis with thrombocytopenia syndrome (TTS) associated adenovirus vector vaccines Vaxzevria or Jcovden. This study aimed to evaluate the impact of these awareness, knowledge implementation practises healthcare professionals (HCP).
We investigated the incidence trend in all major osteoporotic fractures for whole country of Denmark between 1995 and 2010. Hip other declined general population especially among women. But, we observed some increasing men which needs more attention.
Background: In March 2018, the European pregnancy prevention programme for oral retinoids was updated as part of risk minimisation measures (RMM), emphasising their contraindication in pregnant women. Objective: To measure impact 2018 revision RMMs Europe by assessing utilisation patterns isotretinoin, alitretinoin and acitretin, contraceptive measures, testing, discontinuation, occurrence concomitantly with a retinoid prescription. Methods: An interrupted time series (ITS) analysis to...
In- and exclusion criteria of randomized clinical trials (RCTs) aim to include a homogeneous study-population. This study compared characteristics lung cancer patients from phase III RCTs evaluating tyrosine kinase inhibitors (TKIs) or immune checkpoint (ICIs) with in real world setting the United Kingdom.A retrospective was conducted using Clinical Practice Research Datalink GOLD. Patients (N = 9239) first ever registration between 2014 2018 were identified. Eligibility for inclusion...
Little is known about illness perception in patients with pemphigus vulgaris (PV). We designed a cross-sectional study to clarify the beliefs PV.A total of 100 PV (45 men, 55 women) completed Illness Perception Questionnaire-Revised assess seven aspects perception, including chronicity, recurrence, consequences, self and medicine role controlling illness, coherence, emotional representation. The relationship between clinical demographic variables was evaluated.Patients viewed as chronic...
Distinction between alopecia areata (AA) and androgenic (AGA) can be made according to clinical presentation biopsy findings. However, it is sometimes difficult differentiate them, especially when the diffuse pattern of both AA AGA in differential diagnosis hair loss androgen-dependent areas.To evaluate characteristics inflammatory cell infiltration using CD3, CD4, CD8, CD20 antigens, find some consistent histological clues for distinguishing these two entities.A retrospective analysis...
To describe and categorize detailed components of databases in the Neurological Mental Health Global Epidemiology Network (NeuroGEN).An online 132-item questionnaire was sent to key researchers data custodians NeuroGEN North America, Europe, Asia Oceania. From responses, we assessed characteristics including population coverage, follow-up, clinical information, validity diagnoses, medication use latency. We also evaluated possibility conversion into a common model (CDM) implement federated...
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Phototherapy considered as an effective treatment modality in severe cases. Objectives: In this study, we aimed to evaluate the efficacy of bath PUVA (psoralen plus ultraviolet A) and atopic dermatitis. Methods: 28 patients with were included quasi - experimental study. Four left The remained cases underwent three month (thrice weekly, 39 sessions) phototherapy protocol. We started 0.7 J/cm2 increased 0.5 every two...