A5025489096- Atrial Fibrillation Management and Outcomes
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Pregnancy and Medication Impact
- Pharmacovigilance and Adverse Drug Reactions
- Venous Thromboembolism Diagnosis and Management
- Pneumonia and Respiratory Infections
- Pharmaceutical Practices and Patient Outcomes
- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- Bone health and osteoporosis research
- Cardiac Arrhythmias and Treatments
- Bacterial Infections and Vaccines
- Migraine and Headache Studies
- Asthma and respiratory diseases
- Hip and Femur Fractures
- Cervical Cancer and HPV Research
- Inflammatory mediators and NSAID effects
- Advanced Causal Inference Techniques
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Bone health and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Gastrointestinal motility and disorders
- COVID-19 Impact on Reproduction
Agencia Española de Medicamentos y Productos Sanitarios
2014-2024
Universidad Complutense de Madrid
2021-2024
Pharmaceuticals and Medical Devices Agency
2021-2024
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2024
Light Prescriptions Innovators (Spain)
2021
Ministry of Health
2015
Centro Español de Investigación Farmacoepidemiológica
2000-2011
Background: Venous thromboembolism (VTE) manifesting as deep vein thrombosis (DVT) and pulmonary embolism (PE) remains a common vascular disease with high mortality morbidity.Our aim was to study the clinical spectrum of VTE, assess its incidence in general population, evaluate potential risk factors.Methods: Prospective cohort nested casecontrol analysis using General Practice Research Database (1994-2000).Venous newly diagnosed 6550 patients.Cases were compared random sample 10 000...
<h3>Objectives</h3> To study the clinical spectrum of psoriasis and incidence in general population to identify risk factors associated with occurrence psoriasis. <h3>Design</h3> Prospective cohort nested case-control analysis. <h3>Setting</h3> The data source was United Kingdom General Practice Research Database containing computerized information entered by practitioners (GPs). <h3>Patients</h3> comprised patients receiving a first-ever diagnosis between January 1, 1996, December 31, 1997,...
Use of nonsteroidal antiinflammatory drugs (NSAIDs) has been associated with a reduced risk colorectal cancer, but limited information is available on the effect individual nonaspirin NSAIDs. In addition, dose-response relation aspirin in reducing cancer not described. We carried out population-based cohort study secondary case-control analysis to determine association between and use NSAIDs, including role dose duration. The General Practice Research Database U.K. was source population....
We conducted a population-based cohort study to estimate the risk of myopathy associated with use lipid-lowering drugs. Using data from general practices in United Kingdom 1991 through 1997, we identified three cohorts individuals 40 74 years age. One comprised 17,219 persons who had received at least one prescription for drugs period; second consisted patients hyperlipidemia diagnosis not been prescribed (N = 28,974); and third 50,000 population no hyperlipidemia. The incidence rate users...
Studies on drug utilization usually do not allow direct cross-national comparisons because of differences in the respective applied methods. This study aimed to compare time trends BZDs prescribing by applying a common protocol and analyses plan seven European electronic healthcare databases.Crude standardized prevalence rates from 2001-2009 were calculated databases Spain, United Kingdon (UK), The Netherlands, Germany Denmark. Prevalence was stratified age, sex, BZD type [(using ATC codes),...
In May 2020, the ACCESS (The vACCine covid-19 monitoring readinESS) project was launched to prepare real-world of COVID-19 vaccines. Within this project, study aimed generate background incidence rates 41 adverse events special interest (AESI) contextualize potential safety signals detected following administration A dynamic cohort conducted using a distributed data network 10 healthcare databases from 7 European countries (Italy, Spain, Denmark, The Netherlands, Germany, France and United...
Abstract Purpose Base de Datos para la Investigación Farmacoepidemiológica en Atención Primaria (BIFAP) is a population based database administered by the AEMPS (Spanish Agency for Medicines) of longitudinal electronic medical records (EMR) patients attended in primary care. Its main purpose to serve as source information independent studies on drug safety and support medicines regulation activities. This article aim describe characteristics BIFAP, how access summary its potential research....
Chronic treatment with nonsteroidal antiinflammatory drugs (NSAIDs) has been associated a reduced risk of colorectal cancer, but less information is available on the relationship between NSAIDs and adenoma. We carried out population-based cohort study nested case-control analysis to determine association use aspirin individual The General Practice Research Database in United Kingdom was source population. followed 943,903 persons who were 40-79 years age free adenoma or other cancer at...
<b>Objectives:</b> To estimate the risk of a first hospital admission for heart failure (HF) associated with use non-steroidal anti-inflammatory drugs (NSAIDs). <b>Methods:</b> Cohort study nested case–control analysis based on UK General Practice Research Database. Overall, 1396 cases non-fatal HF were identified (January 1997 to December 2000) and compared random sample 5000 controls. <b>Results:</b> The incidence rate was 2.7/1000 person years. Prior clinical diagnosis main independent...
Medications used to treat respiratory diseases include beta-adrenoceptors, antimuscarinics, inhaled and oral corticosteroids, theophyllines. Most of these drugs have been associated indirectly with cardiac rhythm disorders, but epidemiologic evidence is limited.To evaluate the association between occurrence disorders among patients asthma those chronic obstructive pulmonary disease, we conducted a case-control study nested in population-based cohort individuals 10-79 years age registered...
Objectives To evaluate the association between bisphosphonate use and risk of atypical femoral fractures among women aged 65 or older. Design Nested case–control study. Setting General practice research database in Spain. Exposures Use oral bisphosphonates before occurrence cases corresponding index date controls. Bisphosphonate was categorised as ever versus never users. Ever users were divided according to total time since first prescription. Main outcome measures Cases defined years older...
Abstract Purpose There is widespread concern about increases in antibiotic use, but comparative data from different European countries on rates of use are lacking. This study was designed to measure and understand the variation utilization across five countries. Methods Seven healthcare databases with access primary care Denmark, Germany, Netherlands, Spain UK were used compare point 1‐year‐period prevalence between 2004 2009. Descriptive analyses stratified by gender, age type antibiotic....
Aims To estimate the incidence of direct oral anticoagulant drug (DOAC) use in patients with nonvalvular atrial fibrillation and to describe user treatment characteristics 8 European healthcare databases representing 6 countries. Methods Longitudinal utilization study from January 2008 December 2015. A common protocol approach was applied. Annual period incidences standardisation by age sex were performed. Dose adjustment related change renal function as well concomitant potentially...
Estimates of the association between COVID-19 vaccines and myo-/pericarditis risk vary widely across studies due to scarcity events, especially in age- sex-stratified analyses.
Due to established teratogenicity of valproates, the EU risk minimisation measures (RMMs) with a pregnancy prevention programme (PPP) for valproate were updated in March 2018.To investigate effectiveness 2018 RMMs on utilisation five European countries/regions.A multi-database, times series study females childbearing potential (12-55 years) was conducted using electronic medical records from countries/regions (01.01.2010-31.12.2020): Denmark, Tuscany (Italy), Spain, Netherlands, and UK....
Aliment Pharmacol Ther 2011; 33: 969–978 Summary Background Intestinal ischaemia, including ischaemic colitis and acute mesenteric causes significant morbidity mortality. Few population-based studies have estimated incidence potential risk factors for this disease. Aims To estimate the of intestinal ischaemia identify associated in cohorts: (i) patients with irritable bowel syndrome and/or chronic constipation (IBS/CC/both), (ii) individuals free these conditions. Methods Population-based...
Results from observational studies may be inconsistent because of variations in methodological and clinical factors that intrinsically related to the database (DB) where study is performed.The objectives this paper were evaluate impact applying a common protocol benzodiazepines (BZDs) (anxiolytics, hypnotics, drugs) risk hip/femur fracture (HFF) across three European primary care DBs investigate any resulting discrepancies.To measure HFF among adult users BZDs during 2001-2009, cohort nested...
The public-private ADVANCE collaboration developed and tested a system to generate evidence on vaccine benefits risks using European electronic healthcare databases. In the safety of vaccines, background incidence rates are key allow proper monitoring assessment. goals this study were compute age-, sex-, calendar-year stratified nine autoimmune diseases in seven databases from four countries assess validity by comparing with published data.Event calculated for following outcomes: acute...
Summary Objective The annual prevalence of antiepileptic drug ( AED ) prescribing reported in the literature differs considerably among E uropean countries due to use different type data sources, time periods, population distribution, and methodologic differences. This study aimed measure across seven routine health care databases S pain, D enmark, N etherlands, U nited K ingdom, Germany using a standardized methodology investigate sources variation. Methods Analyses on s were stratified by...
Abstract Background Observational studies including time‐varying treatments are prone to confounding. We compared Cox regression analysis, propensity score (PS) methods, and marginal structural models (MSMs) in a study of antidepressant [selective serotonin reuptake inhibitors (SSRIs)] use the risk hip fracture. Methods A cohort patients with first prescription for antidepressants (SSRI or tricyclic antidepressants) was extracted from Dutch Mondriaan Spanish Base de datos para la...
The introduction of direct oral anticoagulants (DOACs) has broadened the treatment arsenal for nonvalvular atrial fibrillation, but observational studies on benefit-risk balance DOACs compared to vitamin K antagonists (VKAs) are needed. aim this study was characterize risk major bleeding in DOAC users using longitudinal data collected from electronic health care databases 4 different EU-countries analysed with a common protocol.A cohort conducted among new (≥18 years) or VKAs fibrillation...