A5102967246- Bone health and osteoporosis research
- Hip and Femur Fractures
- Metabolism, Diabetes, and Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bone health and treatments
- Orthopaedic implants and arthroplasty
- Diabetes Treatment and Management
- Rheumatoid Arthritis Research and Therapies
- High voltage insulation and dielectric phenomena
- Total Knee Arthroplasty Outcomes
- Gastroesophageal reflux and treatments
- Inflammatory mediators and NSAID effects
- Health Systems, Economic Evaluations, Quality of Life
- Asthma and respiratory diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Bone and Joint Diseases
- Thermal Analysis in Power Transmission
- Atrial Fibrillation Management and Outcomes
- Respiratory Support and Mechanisms
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Spondyloarthritis Studies and Treatments
- Pelvic and Acetabular Injuries
- Multiple Sclerosis Research Studies
- Pancreatic and Hepatic Oncology Research
Tennet (Netherlands)
2024
Maastricht University
2015-2024
University Medical Center Groningen
2024
University Medical Center
2013-2024
Université Paris Cité
2024
Leiden University Medical Center
2024
Utrecht University
2013-2022
Southampton General Hospital
2013-2022
MRC Lifecourse Epidemiology Unit
2013-2022
University of Southampton
2011-2022
Studies that generate real-world evidence on the effects of medical products through analysis digital data collected in clinical practice provide key insights for regulators, payers, and other healthcare decision-makers. Ensuring reproducibility such findings is fundamental to effective evidence-based decision-making. We reproduce results 150 studies published peer-reviewed journals using same databases as original investigators evaluate completeness reporting 250. Original reproduction...
To evaluate the risk of fracture in patients receiving intermittent therapy with high-dose oral glucocorticoids (GCs).The study group comprised 191,752 from UK General Practice Database who were 40 years age and older received GCs. The followup time period was divided into categories "current" "no exposure." daily dose cumulative for each determined. Relative risks estimated using Cox proportional hazards models, adjusted age, sex, body mass index, smoking, disease history, drug history....
<b>Objectives</b> To estimate fracture risk in patients receiving bariatric surgery versus matched controls. <b>Design</b> Population based, retrospective cohort study. <b>Setting</b> Use of records from the United Kingdom General Practice Research Database, now known as Clinical Datalink (from January 1987 to December 2010). <b>Participants</b> Patients with a body mass index at least 30, record (n=2079), and controls without (n=10 442). Each patient was up six by age, sex, practice, year,...
Microscopic colitis (MC) is a chronic bowel disorder characterised by watery diarrhoea. Nonsteroidal anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs), selective serotonin reuptake (SSRIs) and statins have been associated with MC. However, underlying mechanisms remain unclear.To study the association between exposure to these MC, attention time of exposure, duration, dosage combined test hypotheses on pharmacological mechanisms.A case-control was conducted using British...
OBJECTIVE To assess the risk of colorectal cancer associated with type 2 diabetes, as compared a nondiabetic reference population, and to study additional associations between treatment stage duration obesity risk. RESEARCH DESIGN AND METHODS We conducted an observational population-based cohort within Clinical Practice Research Datalink (1987–2012). All patients (≥18 years) at least one prescription for antidiabetic drug (n = 300,039) were matched (1:1) by birth year, sex, practice...
Stroke increases the risk of hip/femur fracture, as seen in several studies, although time course this increased remains unclear. Therefore, our purpose is to evaluate and investigate any elevated risk.We conducted a case-control study using Dutch PHARMO Record Linkage System database. Cases (n=6763) were patients with first fracture; controls matched by age, sex, region. Odds ratio (OR) for fracture was derived conditional logistic regression analysis, adjusted disease drug history.An...
Objective To assess the incidence and risks of common extra-articular manifestations (EAMs), that is, acute anterior uveitis (AAU), psoriasis inflammatory bowel disease (IBD), in patients with ankylosing spondylitis (AS) compared population-based controls. Methods All incident AS (n=4101) from UK Clinical Practice Research Datalink (1987–2012) were matched up to seven control subjects without by year birth, sex practice (n=28 591). Incidence rates, cumulative rates adjusted (adj) HRs for...
OBJECTIVE The objective of this study was to determine whether treatment with metformin in patients renal impairment is associated a higher risk lactic acidosis or elevated lactate concentrations compared users noninsulin antidiabetic drug (NIAD) who had never used metformin. RESEARCH DESIGN AND METHODS A cohort 223,968 and 34,571 diabetic were identified from the Clinical Practice Research Datalink (CPRD).The primary outcome defined as either CPRD READ code record plasma concentration...
Abstract Purpose Defining a study population and creating an analytic dataset from longitudinal healthcare databases involves many decisions. Our objective was to catalogue scientific decisions underpinning execution that should be reported facilitate replication enable assessment of validity studies conducted in large databases. Methods We reviewed key investigator required operate sample macros software tools designed create analyze cohorts streams data. A panel academic, regulatory,...
Abstract Background We evaluated the risk of pelvic inflammatory disease (PID), ectopic pregnancy, and infertility in women with a previous Chlamydia trachomatis (CT) diagnosis compared who tested negative for CT untested women, considering both targeted incidental (ie, prescribed another indication) use CT-effective antibiotics. Methods This was retrospective study aged 12–25 years at start follow-up within Clinical Practice Research Datalink GOLD database linked to index multiple...
Studies on drug utilization usually do not allow direct cross-national comparisons because of differences in the respective applied methods. This study aimed to compare time trends BZDs prescribing by applying a common protocol and analyses plan seven European electronic healthcare databases.Crude standardized prevalence rates from 2001-2009 were calculated databases Spain, United Kingdon (UK), The Netherlands, Germany Denmark. Prevalence was stratified age, sex, BZD type [(using ATC codes),...
Abstract Patients with multiple sclerosis (MS) may be at an increased risk of fracture owing to a greater falling and decreased bone mineral density when compared the general population. This study was designed estimate relative absolute in patients MS. We conducted population-based cohort using data from UK General Practice Research Database linked National Hospital Registry (1997–2008). Incident MS (n = 5565) were matched 1:6 by year birth, sex, practice without (controls). Cox...
Defining a study population and creating an analytic dataset from longitudinal healthcare databases involves many decisions. Our objective was to catalogue scientific decisions underpinning execution that should be reported facilitate replication enable assessment of validity studies conducted in large databases.We reviewed key investigator required operate sample macros software tools designed create analyze cohorts streams data. A panel academic, regulatory, industry experts database...
To our knowledge, an observational study on the remission of type 2 diabetes mellitus (T2DM) after different types bariatric surgery based data from general practice has not been carried out.To assess effect in patients with T2DM compared matched control patients, and improvement glycemic related clinical parameters.A retrospective cohort conducted May 2013 to 2014 within Clinical Practice Research Datalink involving 2978 a record (2005-2012) body mass index (calculated as weight kilograms...
Abstract Objectives We wanted to estimate the magnitude of risk from all-cause, cause-specific and sex-specific mortality in patients with SLE relative risks compared matched controls evaluate influence exposure medication on SLE. Methods conducted a population-based cohort study using Clinical Practice Research Datalink, Hospital Episode Statistics national death certificates (from 1987 2012). Each patient (n = 4343) was up six 21 780) by age sex. Cox proportional hazards models were used...
The use of inhaled corticosteroids has been associated with a dose-related increased risk fracture. This may be related to systemic absorption. However, several studies have found that patients more severe reductions in pulmonary function had reduced bone mineral density, independent corticosteroids. objective this study was evaluate the relationship between disease severity and fracture risk. A large case–control (108,754 cases) conducted using data from UK General Practice Research...
Previous studies evaluated the association between proton pump inhibitor (PPI) use and subsequent fracture risk, but they showed ambiguous results. Therefore, objective was to evaluate this in a different study population. Our findings show that there is probably no causal relationship PPI hip risk. To further test these conflicting results, of PPIs risk hip/femur A case-control conducted using data from Dutch PHARMO record linkage system. The population included 6,763 cases aged 18 years...