A5051231925- Bone health and osteoporosis research
- Diabetes Treatment and Management
- Bone health and treatments
- Bone and Joint Diseases
- Hip and Femur Fractures
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metabolism, Diabetes, and Cancer
- Lung Cancer Treatments and Mutations
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gastroesophageal reflux and treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Peptidase Inhibition and Analysis
- Asthma and respiratory diseases
- Rheumatoid Arthritis Research and Therapies
- Respiratory Support and Mechanisms
- Pharmaceutical Practices and Patient Outcomes
- Neuroendocrine Tumor Research Advances
- Parkinson's Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Pelvic and Acetabular Injuries
- Medication Adherence and Compliance
- Scoliosis diagnosis and treatment
- Systemic Lupus Erythematosus Research
- Medical Imaging Techniques and Applications
Pharmo Institute
2015-2024
Utrecht University
2015-2024
Maastricht University
2013-2024
Maastricht University Medical Centre
2015-2024
University Medical Center
2017-2024
Cardiovascular Institute Hospital
2020
Pharmac
2020
University Hospital and Clinics
2017-2020
Zorginstituut Nederland
2015-2016
University Medical Center Utrecht
2015
Abstract Background We evaluated the risk of pelvic inflammatory disease (PID), ectopic pregnancy, and infertility in women with a previous Chlamydia trachomatis (CT) diagnosis compared who tested negative for CT untested women, considering both targeted incidental (ie, prescribed another indication) use CT-effective antibiotics. Methods This was retrospective study aged 12–25 years at start follow-up within Clinical Practice Research Datalink GOLD database linked to index multiple...
<b>Objective</b> To determine the association between use of sulphonylureas and risk hypoglycaemia in relation to renal function sulphonylurea metabolic group compared with metformin. <b>Design</b> Population based cohort study using routinely collected data from general practices England. <b>Setting</b> Clinical Practice Research Datalink (CPRD) database, 2004-12. <b>Participants</b> 120 803 new users a non-insulin antidiabetic agent at least one prescription aged 18...
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a new class of drugs that might have potential beneficial effect on bone metabolism. Data the GLP-1 RAs and fracture risk lacking. The aim present study was to investigate association between use fracture. A case-control performed using Danish National Health Service data. Cases were those who sustained controls without during period (2007-2011), all aged 18 years above. Conditional logistic regression estimated odds ratios (OR) with...
Glucagon-like Peptide-1 receptor agonists (GLP1-ra) are a relatively new class of anti-hyperglycemic drugs which may positively affect bone metabolism and thereby decrease (osteoporotic) fracture risk. Data on the effect GLP1-ra risk scarce limited to clinical trial data only. The aim this study was investigate, in population-based cohort, association between use We conducted cohort study, with from Clinical Practice Research Datalink (CPRD) database (2007–2012). population (N = 216,816)...
We examined the effect of cumulative exposure to high doses oral glucocorticoids on fracture risk. Compared short-course users (daily dose ≥ 15 mg + < 1 g), heavy g) had highest risk fracture. These patients should be monitored for management strategies. The daily remains debated. therefore aimed examine hip associated with short courses and use high-dosed glucocorticoids. conducted a population-based case-control study using Danish National Health Service data, 1996–2011. Cases were those...
Patients with rheumatoid arthritis (RA) commonly use oral glucocorticoids (GCs) and proton pump inhibitors (PPIs), both associated osteoporotic fractures. We investigated the association between concomitant of GCs PPIs risk fractures among patients RA.This was a cohort study including RA aged 50+ years from Clinical Practice Research Datalink 1997 2017. Exposure to stratified by most recent prescription as current (<6 months), (7-12 months) past (>1 year); average daily cumulative dose;...
Abstract Background Numerous studies have investigated the potential association of sodium-glucose co-transporter-2 inhibitors (SGLT2-Is) with an increased risk lower limb amputations (LLAs), but produced conflicting results. Particularly comparing SGLT2-Is to glucagon-like peptide-1 receptor agonists (GLP1-RAs) seem find a higher LLA SGLT2-I use. This raises question whether results are driven by protective GLP1-RA-effect rather than harmful SGLT2-I-effect. GLP1-RAs could promote wound...
In the present study, we used national health care databases to estimate fracture incidence rates (IRs) and compared these IRs based on imputed data. We showed that imputation could lead both over- underestimation of IRs, future research should therefore focus how improve those imputations. Osteoporosis is a major public burden through associated (osteoporotic) fractures. Denmark, hip are widely available. However, there limited data about other sites. A recent report only provide although...
To investigate the association between long-term dipeptidyl peptidase-4 (DPP-4) inhibitor use and risk of fracture among people with type 2 diabetes mellitus (T2DM).A retrospective population-based cohort study, using data from Clinical Practice Research Datalink database (2007-2015), was conducted. All those (N = 328 254) at least one prescription for a non-insulin antidiabetic drug (NIAD), aged ≥18 years time collection, were included. Cox proportional hazards models used to estimate...
We investigated the incidence trend in all major osteoporotic fractures for whole country of Denmark between 1995 and 2010. Hip other declined general population especially among women. But, we observed some increasing men which needs more attention. The is varied across globe, there no updated information case (MOF). Thus, rates (IRs) MOF 50+ adults over period 1995–2010. A series cross-sectional analyses was done using Danish National Health Service Register. Participants were full with a...
To investigate the association between use of incretin agents and risk pancreatic cancer.A retrospective population-based cohort study, using data from Clinical Practice Research Datalink, 2007-2012, was conducted. Patients (n = 182 428) with at least one non-insulin antidiabetic drug (NIAD) prescription aged ≥18 years during collection, were matched one-to-one to control patients without diabetes. Multivariable Cox proportional hazards models a new user design used estimate hazard ratio...
Clinical trials have shown that low-dose glucocorticoid therapy in patients with RA reduces bone loss hands or hip, but the effect on osteoporotic fractures is not yet clear. Therefore, we investigated use of oral glucocorticoids and risk among RA.
Abstract Aims/hypothesis Type 2 diabetes is a highly heterogeneous disease for which new subgroups (‘clusters’) have been proposed based on severity: moderate age-related (MARD), obesity-related (MOD), severe insulin-deficient (SIDD) and insulin-resistant (SIRD). It unknown how severity reflected in terms of quality life these clusters. Therefore, we aimed to investigate the cluster characteristics cluster-wise evolution previously defined clusters type diabetes. Methods We included...
Androgen Deprivation Therapy (ADT) increases long-term fracture risk in prostate cancer. Our study showed a higher within six months of ADT use, and current use was associated with fragility fractures. Attention is needed for the prevention fractures at start ADT.
The relationship between type 2 diabetes and gout is complex. objective of this study was to understand the role itself its comorbidities within association gout.We conducted a retrospective cohort using UK Clinical Practice Research Datalink (CPRD) GOLD. Persons with were identified as persons on noninsulin antidiabetic drug (NIAD) 2004 2012, matched 1 control based age, sex, general practice. We estimated risk in NIAD users Cox regression analysis. All analyses stratified for sex.In total,...
Dipeptidyl peptidase-4 inhibitors (DPP4-Is) are a new class of anti-hyperglycemic drugs which might have potential beneficial effect on bone metabolism. Data the DPP4-I use and fracture risk is limited conflicting. The aim present study was to investigate association between DPP4-Is risk.A case-control conducted using data from Danish National Health Service. Cases were those who sustained fracture, controls without during period (2007-2011), all aged 18 years older. Conditional logistic...
To determine the association between use of incretin agents (dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists) for treatment type 2 diabetes mellitus (T2DM) risk any, acute chronic pancreatitis.A population-based cohort study was conducted using data from UK Clinical Practice Research Datalink (CPRD 2007-2012). A total 182 428 adult patients with ≥1 non-insulin antidiabetic drug (NIAD) prescription were matched to control subjects without diabetes. Cox...
To investigate the risk of various types infections (pneumonia and urinary tract infection (UTI)), infection-related mortality in patients with gout compared population-based controls. A retrospective cohort study was conducted using data from UK Clinical Practice Research Datalink (CPRD). All a first diagnosis aged >40 years between January 1987-July 2014, were included matched up to two Time-varying Cox proportional hazards models used estimate mortality. 131,565 252,763 controls (mean...