A5032674395- Multiple Sclerosis Research Studies
- Metabolism, Diabetes, and Cancer
- Bone health and osteoporosis research
- Rheumatoid Arthritis Research and Therapies
- Bone health and treatments
- Cancer Risks and Factors
- Spondyloarthritis Studies and Treatments
- Pancreatic and Hepatic Oncology Research
- Inflammatory mediators and NSAID effects
- Autoimmune and Inflammatory Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Orthopaedic implants and arthroplasty
- Cancer-related Molecular Pathways
- Bladder and Urothelial Cancer Treatments
- Bariatric Surgery and Outcomes
- Pharmacovigilance and Adverse Drug Reactions
- Diabetes Treatment and Management
- Advanced Causal Inference Techniques
- Hip and Femur Fractures
- Sarcoidosis and Beryllium Toxicity Research
- Pharmaceutical Practices and Patient Outcomes
- Parkinson's Disease and Spinal Disorders
- Statistical Methods in Clinical Trials
Utrecht University
2015-2025
Pharmo Institute
2010-2021
Maastricht University Medical Centre
2012-2013
University of Applied Sciences Utrecht
2013
NIHR Oxford Musculoskeletal Biomedical Research Centre
2012
Amsterdam UMC Location Vrije Universiteit Amsterdam
2012
MRC Lifecourse Epidemiology Unit
2012
University of Southampton
2012
University of Oxford
2012
Aarhus University Hospital
2012
<b>Objectives</b> To estimate fracture risk in patients receiving bariatric surgery versus matched controls. <b>Design</b> Population based, retrospective cohort study. <b>Setting</b> Use of records from the United Kingdom General Practice Research Database, now known as Clinical Datalink (from January 1987 to December 2010). <b>Participants</b> Patients with a body mass index at least 30, record (n=2079), and controls without (n=10 442). Each patient was up six by age, sex, practice, year,...
OBJECTIVE To assess the risk of colorectal cancer associated with type 2 diabetes, as compared a nondiabetic reference population, and to study additional associations between treatment stage duration obesity risk. RESEARCH DESIGN AND METHODS We conducted an observational population-based cohort within Clinical Practice Research Datalink (1987–2012). All patients (≥18 years) at least one prescription for antidiabetic drug (n = 300,039) were matched (1:1) by birth year, sex, practice...
Objective To assess the incidence and risks of common extra-articular manifestations (EAMs), that is, acute anterior uveitis (AAU), psoriasis inflammatory bowel disease (IBD), in patients with ankylosing spondylitis (AS) compared population-based controls. Methods All incident AS (n=4101) from UK Clinical Practice Research Datalink (1987–2012) were matched up to seven control subjects without by year birth, sex practice (n=28 591). Incidence rates, cumulative rates adjusted (adj) HRs for...
Abstract Patients with multiple sclerosis (MS) may be at an increased risk of fracture owing to a greater falling and decreased bone mineral density when compared the general population. This study was designed estimate relative absolute in patients MS. We conducted population-based cohort using data from UK General Practice Research Database linked National Hospital Registry (1997–2008). Incident MS (n = 5565) were matched 1:6 by year birth, sex, practice without (controls). Cox...
Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes death. We conducted a population-based cohort study using the General Practice Research Database, Hospital Episode Statistics, national death certificates (January 2001 through March 2008). To each patient MS (n = 1270), up to six referent subjects without were matched by age, gender, practice. Cox...
Different studies have reported an association between HIV infection, antiretroviral therapies, and impaired bone metabolism, but data on their impact fracture risk are scarce. We studied the a clinical diagnosis of infection risk.We conducted case-control study using from Danish National Health Service registries, including 124,655 cases 373,962 age- gender-matched controls. Odds ratios (ORs) 95% confidence intervals (CIs) were estimated conditional logistic regression.A total 50...
To investigate the incidence and risk of ischaemic heart disease (IHD) acute myocardial infarction (AMI), including role non-steroidal anti-inflammatory drugs (NSAID), in patients with ankylosing spondylitis (AS) compared population controls.All newly diagnosed AS (n=3809) from British Clinical Practice Research Datalink (1987-2012) were matched up to seven persons without by year birth, gender practice (n=26 197). Incidence rate ratios (IRR) HRs for development IHD AMI calculated. Stepwise...
The aim of this work was to investigate the relationship between use certain insulins and risk for cancer, when addressing limitations biases involved in previous studies.National Health Registries from Denmark (1996-2010), Finland (1996-2011), Norway (2005-2010) Sweden (2007-2012) UK Clinical Practice Research Datalink database (1987-2013) were used conduct a cohort study on new insulin users (N = 327,112). By using common data model semi-aggregate approach, we pooled individual-level...
<h3>Objective:</h3> To examine the risk of fracture in patients with multiple sclerosis (MS) compared population-based controls. <h3>Methods:</h3> A cohort study was performed Dutch PHARMO Record Linkage System (1998–2008). Patients MS (n = 2,415) were matched by year birth, sex, and practice to up 6 without (controls). We used Cox proportional hazards models estimate hazard ratio (HR) MS. Time-dependent adjustments made for age, history disease, drug use. <h3>Results:</h3> During follow-up,...
Real-world evidence (RWE) is increasingly used for medical regulatory decisions, yet concerns persist regarding its reproducibility and hence validity. This study addresses challenges associated with diversity across real-world data sources (RWDS) repurposed secondary use in pharmacoepidemiologic studies. Our aims were to identify, describe characterize practices, recommendations tools collecting reporting RWDSs, explore how leveraging could improve the quality of evidence.
The use of thiazolidinediones (TZDs) has been associated with increased fracture risks. Our aim was to estimate the risk TZDs in three different healthcare registries, using exactly same study design, and perform an individual patient data meta-analysis these studies.Population-based cohort studies were performed utilizing British General Practice Research Database (GPRD), Dutch PHARMO Record Linkage System (RLS), Danish National Health Registers. In all databases, exposed consisted patients...
This study was set out to determine whether metformin use influences survival in breast cancer patients treated with antidiabetic drugs as compared non-users.We used data from the Danish national registries (1996-2008) identify adult female diagnosed who were prescribed medication. We performed multivariate Coxproportional hazard regression assess all-cause and cancer-specific mortality risks associated exposure. In a secondary analysis, we stratified of according cumulative number...
Background: Patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis. Objective: To estimate incidence rates fractures in MS patients, stratified by type, sex age, compare these controls. Methods: The case population consisted all patients an accepted diagnosis the Danish Registry (1949–2007). Data were linked National Hospital Discharge Register (1977–2007). ( n = 11,157) 1:6 matched year birth, gender, calendar time region persons without...
To investigate the association between use of incretin agents and risk pancreatic cancer.A retrospective population-based cohort study, using data from Clinical Practice Research Datalink, 2007-2012, was conducted. Patients (n = 182 428) with at least one non-insulin antidiabetic drug (NIAD) prescription aged ≥18 years during collection, were matched one-to-one to control patients without diabetes. Multivariable Cox proportional hazards models a new user design used estimate hazard ratio...
Background: Patients with multiple sclerosis (MS) may be at increased risk of fractures owing to osteoporosis and falling. Objective: To evaluate the fracture in incident MS patients drawn from a dedicated registry compared population-based controls. Methods: We conducted cohort study (1996–2007) utilising Danish National Health Registers that were linked Registry Treatment Registry. Incident (2963 cases) 1:6 matched by year birth, gender, calendar time region persons without (controls). Cox...
<h3>Objective:</h3> To derive a simple score for estimating the long-term risk of osteoporotic and hip fracture in individual patients with MS. <h3>Methods:</h3> Using UK General Practice Research Database linked to National Hospital Registry (1997–2008), we identified incident MS (n = 5,494). They were matched 1:6 by year birth, sex, practice without (control subjects). Cox proportional hazards models used calculate fracture. We fitted regression model general specific factors, final was...
Clinical and observational studies suggest that use of thiazolidinediones (TZDs) is associated with an increased fracture risk. In addition, type 2 diabetes mellitus (T2DM) a risk factor for osteoporotic fracture. Our aim was to estimate risks in TZD users other antidiabetic drugs, classified according proxies disease severity.We conducted population-based cohort study utilizing the Dutch PHARMO database (1998-2008). links pharmacy-dispensing data National Hospital Registry. Oral (n =...
The use of thiazolidinediones (TZDs) has been associated with an increased fracture risk. In addition, type 2 diabetes mellitus (T2DM) linked fracture. We evaluated to what extent the association between TZD and risk is related drug or underlying disease. conducted a population-based cohort study using Danish National Health Registers (1996-2007), which link pharmacy data national hospital registry. Oral antidiabetic users (n = 180,049) were matched 1:3 by year birth sex nonusers. Cox...