E. Douglas Rooke

ORCID: 0000-0002-9174-777X
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About
Contact & Profiles
Research Areas
  • Migraine and Headache Studies
  • Gout, Hyperuricemia, Uric Acid
  • Case Reports on Hematomas
  • Myasthenia Gravis and Thymoma
  • Salivary Gland Tumors Diagnosis and Treatment
  • Cardiovascular Issues in Pregnancy
  • Dementia and Cognitive Impairment Research
  • Gastrointestinal Bleeding Diagnosis and Treatment
  • Gastrointestinal motility and disorders
  • Blood Pressure and Hypertension Studies
  • Meningioma and schwannoma management
  • Abdominal vascular conditions and treatments
  • Autism Spectrum Disorder Research
  • SARS-CoV-2 and COVID-19 Research
  • Health Services Management and Policy
  • Healthcare Systems and Challenges
  • Alcoholism and Thiamine Deficiency
  • Ophthalmology and Eye Disorders
  • Esophageal and GI Pathology
  • Body Contouring and Surgery
  • Behavioral and Psychological Studies
  • Healthcare cost, quality, practices
  • Neurological Disorders and Treatments
  • Cardiovascular Syncope and Autonomic Disorders
  • Cancer Treatment and Pharmacology

University of Dundee
2020-2024

Ninewells Hospital
2020

Edinburgh Royal Infirmary
2011

University of Edinburgh
2011

Mayo Clinic
1956-1962

University of Minnesota
1956

Mayo Clinic in Arizona
1956

Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed determine whether improves major outcomes in ischaemic heart disease.ALL-HEART was multicentre, prospective, randomised, open-label, blinded-endpoint trial done 18 regional centres England and Scotland, recruited from 424 primary care practices. Eligible were aged 60 years or older, disease...

10.1016/s0140-6736(22)01657-9 article EN cc-by The Lancet 2022-10-01

Disturbances of gastrointestinal function have frequently been observed in association with diabetes mellitus. The disorders which reported include gastric atony and dilatation, postprandial abdominal cramping, severe constipation, intractable diarrhea characterized by watery stools, nocturnal exacerbations fecal incontinence. These disturbances attributed many investigators to alterations motility secondary visceral diabetic neuropathy. purpose the present report is call attention a group...

10.2337/diab.5.1.25 article EN Diabetes 1956-01-01

10.1007/978-3-540-29805-2_1466 article EN Springer eBooks 2006-11-02

10.1111/j.1526-4610.1962.hed0203147.x article EN Headache The Journal of Head and Face Pain 1962-10-01

Objectives To describe the incidence of adverse events (AEs), reactogenicity symptoms, menstrual changes and overall self-rated improvement in health well-being after COVID-19 vaccination. Design VAC4COVID is an ongoing prospective, active observational, post-authorisation cohort safety study (PASS) UK-approved vaccines for disease. Setting The conducted through a secure website ( www.vac4covid.com ) by MEMO Research, University Dundee, UK. Participants 16 265 adult (18 years or older) UK...

10.1136/bmjopen-2021-060583 article EN cc-by-nc BMJ Open 2022-06-01

Abstract Background Allopurinol is a xanthine oxidase inhibitor that lowers serum uric acid and used to prevent acute gout flares in patients with gout. Observational small interventional studies have suggested beneficial cardiovascular effects of allopurinol. Objective To determine whether allopurinol improves major outcomes ischaemic heart disease. Design Prospective, randomised, open-label, blinded endpoint multicentre clinical trial. Setting Four hundred twenty-four UK primary care...

10.3310/attm4092 article EN publisher-specific-oa Health Technology Assessment 2024-03-01

<h3>To the Editor.—</h3> I have followed with interest letters concerning use (or lack of it) patient package inserts in March 8 (235:1003,1976) and previous issues of<i>JAMA</i>. In issue, was struck by timely ring Dr Aring's quotation Justice Cardozo his commentary (p 1013)—coming as it did, just a few pages after "insert" discussion: "Justice said that there is an accuracy defeats itself overemphasis details, one must permit oneself, quite advisedly deliberately, certain margin...

10.1001/jama.1976.03270020015013 article EN JAMA 1976-07-12
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