A5060534192- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- S100 Proteins and Annexins
- Traumatic Brain Injury Research
- Respiratory Support and Mechanisms
- Neurosurgical Procedures and Complications
- Neonatal and fetal brain pathology
- Trauma and Emergency Care Studies
- Immune Response and Inflammation
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Climate Change and Health Impacts
- Mitochondrial Function and Pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Acute Ischemic Stroke Management
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Cardiac Ischemia and Reperfusion
- Exercise and Physiological Responses
- Musculoskeletal pain and rehabilitation
- Mechanical Circulatory Support Devices
Western General Hospital
2008-2024
Edinburgh Royal Infirmary
2021-2024
University of Edinburgh
2012-2024
Turku University Hospital
2024
Antwerp University Hospital
2024
University of Basel
2024
Brescia University
2024
NHS Lothian
2015-2024
Edinburgh College
2024
University of Glasgow
2020
In patients with traumatic brain injury, hypothermia can reduce intracranial hypertension. The benefit of on functional outcome is unclear.We randomly assigned adults an pressure more than 20 mm Hg despite stage 1 treatments (including mechanical ventilation and sedation management) to standard care (control group) or (32 35°C) plus care. the control group, 2 (e.g., osmotherapy) were added as needed pressure. only if failed both groups, 3 (barbiturates decompressive craniectomy) used all...
The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because differences in the distribution underlying cerebral small vessel diseases. Therefore, we investigated incidence, characteristics, and outcome lobar nonlobar ICH.In a population-based, prospective inception cohort study ICH, used multiple overlapping sources case ascertainment follow-up to identify validate diagnoses 2010 2011 an adult population 695 335.There were 128 participants with first-ever primary...
Mild traumatic brain injury (TBI) accounts for up to 80% of clinical TBI and can result in cognitive impairment white matter damage that may develop persist over several years. Clinically relevant models mild investigation neurobiological changes the development therapeutic strategies are poorly developed. In this study we investigated temporal profile axonal somal contribute impairments a mouse model TBI. Neuronal perikaryal (hematoxylin eosin Fluoro-Jade C), myelin integrity (myelin basic...
Current understanding of in vivo human brown adipose tissue (BAT) physiology is limited by a reliance on positron emission tomography (PET)/computed (CT) scanning, which has measured exogenous glucose and fatty acid uptake but not quantified endogenous substrate utilization BAT. Six lean, healthy men underwent 18fluorodeoxyglucose-PET/CT scanning to localize BAT so microdialysis catheters could be inserted supraclavicular under CT guidance abdominal subcutaneous white (WAT). Arterial...
Abstract Patients undergo interventions to achieve a ‘normal’ brain temperature; parameter that remains undefined for humans. The profound sensitivity of neuronal function temperature implies the should be isothermal, but observations from patients and non-human primates suggest significant spatiotemporal variation. We aimed determine clinical relevance in by establishing how much it varies healthy adults. retrospectively screened data all recruited Collaborative European NeuroTrauma...
The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and moderate TBI who deteriorate require admission the intensive care unit for intracranial pressure (ICP) management.
Abstract Background Targeted temperature management (TTM) of 32 to 34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 indicated benefit on survival and neurological outcome. In 2013, a trial showed no difference outcome between TTM 33 36 °C. this meta-analysis, we investigate evidence animal models arrest. Methods We searched PubMed EMBASE adult studies using as different or global brain ischemia which reported neurobehavioural outcome,...
There is a lack of consistent, evidence-based guidelines for the management patients with fever after brain injury. The aim was to update previously published consensus recommendations on targeted temperature intracerebral haemorrhage, aneurysmal subarachnoid and acute ischaemic stroke in who require admission critical care.A modified Delphi consensus, Neuroprotective Therapy Consensus Review (NTCR), included 19 international neuro-intensive care experts subspecialty interest stroke. An...
The expression of the neutrophil chemokine macrophage inflammatory protein-2 (MIP-2/CXCL2) and monocyte chemotactic protein-1 (MCP-1/CCL2) have been described in glial cells vitro but their origin following TBI has not established. Furthermore, little is known modulation these chemokines. Chemokine was investigated male Sprague-Dawley rats moderate lateral fluid percussion injury (LFPI). At 0, 4, 8, 12, 24 h after injury, brains were harvested MIP-2/CXCL2 MCP-1/CCL2 levels measured by ELISA....
Background Traumatic brain injury (TBI) is a major cause of disability and death in young adults worldwide. It results around 1 million hospital admissions annually the European Union (EU), causes majority 50,000 deaths from road traffic accidents leaves further ≈10,000 people severely disabled. Objective The Eurotherm3235 Trial was pragmatic trial examining effectiveness hypothermia (32–35 °C) to reduce raised intracranial pressure (ICP) following severe TBI morbidity mortality 6 months...
Traumatic brain injury (TBI) is a significant cause of disability and death huge economic burden throughout the world. Much morbidity associated with TBI attributed to secondary injuries resulting in hypoxia ischemia after initial trauma. Intracranial hypertension decreased partial oxygen tension (PbtO2) are targeted as potentially avoidable causes morbidity. Therapeutic hypothermia (TH) may be an effective intervention reduce intracranial pressure (ICP), but could also affect cerebral blood...
This study sought to determine the bio-availability of recombinant human erythropoietin (EPO) in brain and blood its effects on cerebral concentrations inflammatory mediators interleukin-1beta (IL-1beta) macrophage-inflammation protein-2 (MIP-2) following lateral fluid percussion injury (FPI) rat. After induction moderate FPI (1.6-1.8 atm), EPO was injected intraperitoneally (IP) or intravenously (IV) at doses 1000-5000 U/kg a randomized blinded manner. Animals were then sacrificed time...
There is good evidence that pupil reactivity useful for prognostication in acute head injuries. Despite this, most assessments are subjective and performed by physicians who may not be experts. They can therefore unreliable. We present a case of patient with seemingly irreversible demise from an traumatic subdural haematoma. This was determined assessment his pupils, which were non-reactive to light at the time arrival neurosurgical theatre. He transferred neurointensive care brainstem death...
Clinical trials in traumatic brain injury (TBI) are challenging. Previous of complex interventions were conducted high-income countries, reported long lead times for site setup and low screened-to-recruitment rates. In this report we evaluate the internal pilot phase an international, multicentre TBI trial a intervention to assess: design implementation online case form; feasibility recruitment (sites patients); effectiveness delivery protocol. All aspects as main trial. The had oversight by...
Background: Cerebral contusions contain numerous leukocytes, and a temporal relationship exists among cerebral chemokine expression, leukocyte recruitment, contusion enlargement. This would suggest role for chemokines in development. However, it has not been established if serum concentrations of such as interleukin-8 (IL-8) or monocyte chemoattractant protein-1 (MCP-1) change with Methods: Eighteen adult patients severe contusional traumatic brain injury, on computerized tomography, were...
Objectives: Hypothermia reduces intracranial hypertension in patients with traumatic brain injury but was associated harm the Eurotherm3235Trial. We stratified trial by International Mission for Prognosis and Analysis of Clinical Trials [Traumatic Brain Injury] (IMPACT) extended model sum scores to determine where balance risks lay intervention. Design: The Eurotherm3235Trial a randomized controlled trial, standardized blinded outcome assessment. Patients were split into risk tertiles IMPACT...