A5010238135- Traumatic Brain Injury Research
- Neuroscience and Neuropharmacology Research
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced MRI Techniques and Applications
- S100 Proteins and Annexins
- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Advanced NMR Techniques and Applications
University of Sheffield
2015
Medical Research Council
2015
Cancer Research UK
2015
University of Oxford
2015
University of Edinburgh
2009-2010
Mild traumatic brain injury (TBI) accounts for up to 80% of clinical TBI and can result in cognitive impairment white matter damage that may develop persist over several years. Clinically relevant models mild investigation neurobiological changes the development therapeutic strategies are poorly developed. In this study we investigated temporal profile axonal somal contribute impairments a mouse model TBI. Neuronal perikaryal (hematoxylin eosin Fluoro-Jade C), myelin integrity (myelin basic...
The development of pharmacological magnetic resonance imaging (phMRI) has presented the opportunity for investigation neurophysiological effects drugs in vivo. Psilocin, a hallucinogen metabolised from psilocybin, was recently reported to evoke brain region-specific, phMRI signal changes humans. present study investigated psilocin rat model using and then probed relationship between neuronal haemodynamic responses multimodal measurement preparation. Psilocin (2 mg/kg or 0.03 i.v.) vehicle...
Cerebrovascular risk factors contribute to the development of white matter changes associated with cognitive impairment in elderly. Moreover cerebrovascular dysfunction, due chronic hypoperfusion, may and pathogenesis Alzheimer's disease. We hypothesise that hypoperfusion is a cause dysfunction accelerated decline this additionally precipitates Alzheimer pathology. have developed an experimental mouse model cerebral test firstly characterised structural pathology behavioural wild-type mice....
Traumatic brain injury (TBI) is one of the most robust risk factors for development Alzheimer's Disease with epidemiological studies reporting a threefold increased (Fleminger et al, 2003). Furthermore, neuropathological link has been demonstrated extracellular β-amyloid plaques reported in approximately 30% individuals who died following severe head (Graham 1996; Ikonomovic 2004). However, there increasing evidence that intraneuronal amyloid likely to be an early pathogenic event AD. We...
Widespread damage and dysfunction of axons myelin tracts that comprise white matter in Alzheimer's disease (AD) has been demonstrated by numerous neuropathological, imaging biochemical studies. The relationship changes to the development pathological AD brain are characteristic (plaques, tangles memory loss) underlying mechanisms yet be defined. Head injury is major environmental risk factor for can result persistent cognitive deficits humans. We developed a rodent model head examine between...