A5114374743- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Photoreceptor and optogenetics research
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Molecular Sensors and Ion Detection
- Nuclear Receptors and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Stress, Anesthesia, and Immune Response
- Genetics and Neurodevelopmental Disorders
- Alcoholism and Thiamine Deficiency
- Neonatal and fetal brain pathology
- Melanoma and MAPK Pathways
- Photochromic and Fluorescence Chemistry
- Neurogenesis and neuroplasticity mechanisms
- S100 Proteins and Annexins
- Genetics, Aging, and Longevity in Model Organisms
- Diabetes and associated disorders
- Stress Responses and Cortisol
Centre National de la Recherche Scientifique
2007-2024
Inserm
2013-2024
Neurosciences Paris-Seine
2014-2024
Sorbonne Université
2010-2024
Institut de Biologie Paris-Seine
2014-2024
Université Paris-Seine
2006-2024
Université Sorbonne Nouvelle
2022-2024
University of Edinburgh
2008-2017
Centre Hospitalier Universitaire Amiens-Picardie
2017
Université de Rouen Normandie
2017
Studies on human and animals shed light the unique hippocampus contributions to relational memory. However, particular role of each hippocampal subregion in memory processing is still not clear. Hippocampal computational models theories have emphasized a function for subregion, with CA3 area acting as an autoassociative network CA1 critical output structure. In order understand respective roles CA3- CA1-hippocampal areas formation contextual memory, we studied effects reversible inactivation...
Mild traumatic brain injury (TBI) accounts for up to 80% of clinical TBI and can result in cognitive impairment white matter damage that may develop persist over several years. Clinically relevant models mild investigation neurobiological changes the development therapeutic strategies are poorly developed. In this study we investigated temporal profile axonal somal contribute impairments a mouse model TBI. Neuronal perikaryal (hematoxylin eosin Fluoro-Jade C), myelin integrity (myelin basic...
Abstract Synaptic loss, plaques and neurofibrillary tangles are viewed as hallmarks of Alzheimer’s disease (AD). This study investigated synaptic markers in neocortical Brodmann area 9 (BA9) samples from 171 subjects with without AD at different levels cognitive impairment. The expression vesicular glutamate transporters (VGLUT1&2), uptake site (EAAT2), post-synaptic density protein 95 kD (PSD95), GABA/glycine transporter (VIAAT), somatostatin (som), synaptophysin choline acetyl...
Hippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses GABA/glycine vesicular transporters (VIAAT) atypical type III glutamate transporter (VGLUT3); therefore, these have ability signal with both glutamate. transmission by has been extensively characterized but nothing is known about functional implications VGLUT3-dependent released cells. Here, using...
Abstract Lesion studies have demonstrated the prominent role of hippocampus in spatial and contextual learning. To better understand how information is processed CA3 region during learning, we focused on autoassociative network hypothesis. We took advantage a particularity mossy fibre (MF) synapses, i.e. their high zinc concentration, to reversibly disrupt afferent MF pathway by microinfusions an intracellular (DEDTC) or extracellular (CaEDTA) chelator into area dorsal mice. Disruption...
Abstract Cholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3 (VGLUT3) which allows them to regulate network with and acetylcholine (ACh). In addition, VGLUT3-dependent increases ACh stores through synergy. A missense polymorphism, VGLUT3-p.T8I, was identified in patients substance use disorders (SUDs) eating (EDs). mouse line generated understand neurochemical behavioral impact of p.T8I variant. VGLUT3 T8I/T8I male mice, signaling unchanged but synergy...
Two experiments were conducted to investigate the possibility of faster forgetting by PDAPP mice (a well-established model Alzheimer’s disease as reported Games and colleagues in an earlier paper). Experiment 1, using aged 13–16 mo, confirmed presence a deficit spatial reference memory task water maze hemizygous relative littermate controls. However, after overtraining criterion equivalent navigational performance, series retention tests revealed group. Very limited retraining was sufficient...
Elucidating the functional properties of dentate gyrus (DG), CA3, and CA1 areas is critical for understanding role dorsal hippocampus in contextual fear memory processing. In order to specifically disrupt various hippocampal inputs, we used region-specific infusions DCG-IV, metabotropic glutamate receptor agonist, which selectively disrupts entorhinal outputs as well mossy fiber transmission hippocampus. The consequences these injections were studied using a conditioning (CFC) paradigm....
We studied the role of testosterone, mediated by androgen receptor (AR), in modulating temporal order memory for visual objects. For this purpose, we used male mice lacking AR specifically nervous system. Control and mutant males were gonadectomized at adulthood supplemented with equivalent amounts testosterone to normalize their hormonal levels. found that neural deletion selectively impaired processing information objects, without affecting classical object recognition or anxiety-like...
We investigated the specific role of zinc present in large amounts synaptic vesicles mossy fibers and coreleased with glutamate CA3 region. In previous studies, we have shown that blockade after release has no effect on consolidation spatial learning, while is required for contextual fear conditioning. Although both are hippocampo-dependent processes, conditioning to context implies a strong emotional burden. To verify hypothesis could play enabling sustainable memorization single event...
Abstract The later stages of long-term potentiation (LTP) in vitro and spatial memory vivo are believed to depend upon gene transcription. Accordingly, considerable attempts have been made identify both the mechanisms by which transcription is regulated indeed products themselves. Previous studies shown that deletion one regulator transcription, mitogen- stress-activated kinase 1 (MSK1), causes an impairment memory. Given ability MSK1 regulate expression via phosphorylation cAMP response...
One peculiarity of the hippocampal CA3 mossy fiber terminals is co-release zinc and glutamate upon synaptic transmission. How these two players act on hippocampal-dependent memories still unclear. To decipher their respective involvement in memory consolidation, a pharmacological approach was chosen. Using behavioral paradigms (water maze contextual fear conditioning) we now report that at synapses necessary sufficient for spatial learning consolidation process, whereas released by fibers...
Several subtypes of modulatory neurons co-express vesicular glutamate transporters (VGLUTs) in addition to their cognate transporters. These are believed establish new forms neuronal communication. The atypical VGLUT3 is particular interest since the striatum this subtype found tonically active cholinergic interneurons (TANs) and a subset 5-HT fibers. plays major role psychomotor effects induced by amphetamine. Whether how VGLUT3-operated glutamate/ACh or glutamate/5HT co-transmissions...
The atypical vesicular glutamate transporter type 3 (VGLUT3) is expressed by subpopulations of neurons using acetylcholine, GABA, or serotonin as neurotransmitters. In addition, VGLUT3 in the inner hair cells auditory system. A mutation (p.A211V) gene that encodes responsible for progressive deafness two unrelated families. this study, we investigated consequences p.A211V cell cultures and CNS a mutant mouse. substantially decreased expression (-70%). We measured VGLUT3-p.A211V activity...
Abstract Earlier diagnosis and treatment of Alzheimer’s disease would greatly benefit from the identification biomarkers at prodromal stage. Using a prominent animal model aspects disease, we here show using clinically relevant methodologies that very young, pre-pathological PDAPP mice, which overexpress mutant human amyloid precursor protein in brain, exhibit two cryptic deficits are normally undetected standard methods assessment. Despite learning spatial memory task displaying normal...
Magnesium sulfate (MgSO4) administration to mothers at risk of preterm delivery is proposed as a neuroprotective strategy against neurological alterations such cerebral palsy in newborns. However, long-term beneficial or adverse effects MgSO4 and sex-specific sensitivity remain be investigated. We conducted behavioral neurochemical studies males females, from the perinatal period adolescence mouse model neonatal lesion. The lesion was produced 5-day-old (P5) pups by ibotenate intracortical...