A5077645715- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Renal Diseases and Glomerulopathies
- Metabolism and Genetic Disorders
- Organ Donation and Transplantation
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Social Sciences and Governance
- French Urban and Social Studies
- Health, Medicine and Society
- Stress Responses and Cortisol
- Healthcare Systems and Practices
- Neuroinflammation and Neurodegeneration Mechanisms
- Education, sociology, and vocational training
- Pharmacogenetics and Drug Metabolism
- Receptor Mechanisms and Signaling
- Renal Transplantation Outcomes and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Drug Transport and Resistance Mechanisms
- Tissue Engineering and Regenerative Medicine
- Human Health and Disease
- Urinary Tract Infections Management
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Multiculturalism, Politics, Migration, Gender
Inserm
2010-2025
Université de Montpellier
2023-2025
Institut de Génomique Fonctionnelle
2022-2025
Centre National de la Recherche Scientifique
1985-2025
Massachusetts General Hospital
2013-2024
Harvard University
2013-2024
Harvard Stem Cell Institute
2017-2024
Broad Institute
2017-2024
Sorbonne Université
2010-2020
Hôpital Saint-Antoine
2020
Oxytocin receptor (Oxtr) signaling in neural circuits mediating discrimination of social stimuli and affiliation or avoidance behavior is thought to guide recognition. Remarkably, the physiological functions Oxtrs hippocampus are not known. Here we demonstrate using genetic pharmacological approaches that anterior dentate gyrus (aDG) CA2/CA3 (aCA2/CA3) mice necessary for social, but non-social, stimuli. Further, aCA2/CA3 neurons recruit a population-based coding mechanism mediate...
Adult-born dentate granule neurons contribute to memory encoding functions of the gyrus (DG) such as pattern separation. However, local circuit-mechanisms by which adult-born partake in this process are poorly understood. Computational, neuroanatomical and electrophysiological studies suggest that sparseness activation cell layer (GCL) is conducive for A sparse coding scheme thought facilitate distribution similar entorhinal inputs across GCL decorrelate overlapping representations minimize...
The ternary complex factor (TCF) Elk-1 is a transcription that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site. associated with dimer of (SRF) at SRE site, and its phosphorylation occurs specific residues in to mitogen-activated protein kinases (MAPKs), including c-Jun-N terminal kinase (JNK), p38/MAPK, extracellular-signal regulated (ERK). This event critical for triggering SRE-dependent transcription. Although MAPKs are fundamental...
Hepatocytes isolated from adult fasted rats and cultured in the presence of thyroid hormones, glucocorticoids, a serum-free medium conserve essentials their differentiated function hormonal sensitivity for at least 1 week. In these cells, gene L-type pyruvate kinase is expressed only when glucose insulin are present together, each them being inactive by itself. Inhibition expression which occurs and/or removed culture not associated with accumulation phosphoenolpyruvate carboxykinase mRNA,...
The histone deacetylase SIRT6 promotes DNA repair, but its activity declines with age a concomitant accumulation of damage. Furthermore, knockout mice exhibit an accelerated aging phenotype and die prematurely. Here, we report that brain-specific SIRT6-deficient survive present behavioral defects major learning impairments by 4 months age. Moreover, the brains these show increased signs damage, cell death, hyperphosphorylated Tau—a critical mark in several neurodegenerative diseases....
The dentate gyrus (DG) of mammals harbors neural stem cells that generate new granule (DGCs) throughout life. Behavioral studies using the contextual fear discrimination paradigm have found selectively augmenting or blocking adult hippocampal neurogenesis enhances impairs under conditions high, but not low, interference suggestive a role in pattern separation. Although engages population-based coding mechanisms underlying separation such as global remapping DG and CA3, how modulates is...
Considerable work emphasizes a role for hippocampal circuits in governing contextual fear discrimination. However, the intra- and extrahippocampal pathways that route information to cortical subcortical guide adaptive behavioral responses are poorly understood. Using terminal-specific optogenetic silencing discrimination learning paradigm, we identify opposing roles dorsal CA3-CA1 (dCA3-dCA1) projections CA3-dorsolateral septum (dCA3-DLS) calibrating certain ambiguous threats, respectively....
Nervous system injury is a frequent result of cancer therapy involving cranial irradiation, leaving patients with marked memory and other neurobehavioral disabilities. Here, we report an unanticipated link between bone marrow brain in the setting radiation injury. Specifically, demonstrate that marrow-derived monocytes macrophages are essential for structural functional repair mechanisms, including regeneration cerebral white matter improvement neurocognitive function. Using...
Activation of the extracellular signal-regulated kinase (ERK) signaling pathway in striatum is crucial for molecular adaptations and long-term behavioral alterations induced by cocaine. In response to cocaine, ERK controls phosphorylation levels both mitogen stress-activated protein 1 (MSK-1), a nuclear involved histone H3 (Ser10) cAMP element binding phosphorylation, Elk-1, transcription factor serum (SRE)-driven gene regulations. We recently characterized phenotype msk-1 knock-out mice...