A5046131924- Hair Growth and Disorders
- melanin and skin pigmentation
- Skin Protection and Aging
- Retinoids in leukemia and cellular processes
- Herpesvirus Infections and Treatments
- RNA regulation and disease
- Biotin and Related Studies
- Dermatologic Treatments and Research
- Vitamin C and Antioxidants Research
- Virus-based gene therapy research
- Biochemical Analysis and Sensing Techniques
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
Cold Spring Harbor Laboratory
2024
Stony Brook University
2024
Harvard University
2020-2021
Harvard Stem Cell Institute
2020-2021
Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk. However, whether pro-oxidants protect from PC remained unclear. In this work, we show that a pro-oxidant K precursor [menadione sodium bisulfite (MSB)] suppresses progression in mice, killing cells through an oxidative cell death: MSB antagonizes the essential class III phosphatidylinositol (PI) 3-kinase VPS34-the regulator of endosome identity and sorting-through oxidation key cysteines, pointing to redox...
Abstract Stress is a risk factor for many skin conditions, but the cellular and molecular mechanisms of its impacts have only begun to be revealed. In mice, acute stress induces loss melanocyte stem cells (MeSCs) premature hair greying. Our previous work demonstrated that MeSCs upon caused by hyperactivation sympathetic nervous system. also secretion hormones from hypothalamic–pituitary–adrenal (HPA) axis; however, whether are involved in greying process has not been fully examined....
These authors report that in mice the stress hormone corticosterone (the rodent equivalent of cortisol humans) acts on dermal papillae to suppress expression Gas6 (encoding growth arrest specific 6) and thereby cause hair follicle stem cell (HFSC) quiescence reduced growth. They show chronic stress, high levels prolong HFSC maintain follicles an extended resting phase.