A5002375093- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Nitric Oxide and Endothelin Effects
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Zebrafish Biomedical Research Applications
- Neuroscience of respiration and sleep
- Neuroscience, Education and Cognitive Function
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Memory Processes and Influences
- Olfactory and Sensory Function Studies
- Regulation of Appetite and Obesity
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Ion channel regulation and function
- Epilepsy research and treatment
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
University of Edinburgh
2016-2025
Simons Foundation
2025
Instituto de Neurociencias
2015-2023
Discovery Centre
2022
National Centre for Biological Sciences
2022
Tata Institute of Fundamental Research
2022
Institut des Sciences Cognitives Marc Jeannerod
2022
Simons Initiative for the Developing Brain
2021
University of Bristol
1977-2020
Institute for Stem Cell Biology and Regenerative Medicine
2016-2018
Memory encoding occurs rapidly, but the consolidation of memory in neocortex has long been held to be a more gradual process. We now report, however, that systems can occur extremely quickly if an associative "schema" into which new information is incorporated previously created. In experiments using hippocampal-dependent paired-associate task for rats, flavor-place associations became persistent over time as putative neocortical schema gradually developed. New traces, trained only one...
We have determined the volume and location of hippocampal tissue required for normal acquisition a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions 20-100% volume. Even small transverse block (minislab) hippocampus (down 26% total) could support learning in water maze, provided it at septal (dorsal) pole hippocampus. Lesions pole, leaving 60% hippocampi intact, caused deficit, although electrophysiological responses, synaptic plasticity, preserved...
The generality of the place-learning impairment associated with hippocampal system damage was challenged using methods training that permitted subjects to form an individual association between place escape and a particular navigational route in open-field water maze. Both normal rats fornix lesions (FX rats) acquired this task rapidly, although FX were slightly slower achieving minimum latencies. In postcriterion testing, occasionally made near misses but, more often, their performance...
This paper reports a series of 5 experiments concerned with possible role for N-methyl-D-aspartate (NMDA) receptors in certain types learning. The results show that chronic intraventricular infusion the NMDA receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (D,L- AP5) caused an impairment spatial but not visual discrimination learning rats. Such selectivity occurred despite widespread distribution drug throughout CNS. AP5 sometimes disturbance sensorimotor function during learning,...
Abstract This study examined the effects of ibotenic acid‐induced lesions hippocampus, subiculum and hippocampus ± upon capacity rats to learn perform a series allocentric spatial learning tasks in an open‐field water maze. The were made by infusing small volumes neurotoxin at total 26 (hippocampus) or 20 (subiculum) sites intended achieve complete target cell loss but minimal extratarget damage. regional extent axon‐sparing nature these was evaluated using both cresyl violet Fink – Heimer...
When new learning occurs against the background of established prior knowledge, relevant information can be assimilated into a schema and thereby expand knowledge base. An animal model this important component memory consolidation reveals that systems very fast. In experiments with rats, we found hippocampal-dependent paired associates is associated striking up-regulation immediate early genes in prelimbic region medial prefrontal cortex, pharmacological interventions targeted at area...
We investigated the role of NMDA receptors in memory encoding and retrieval. A delayed matching-to-place (DMP) paradigm watermaze was used to examine 1-trial spatial rats. Over periods up 21 days, 4 daily trials were given an escape platform hidden a new location each day, with interval (ITI) varying from 15 sec 2 hours between 1 2, but always at for remaining ITIs. Using chronic i.c.v. infusions D-AP5, acute intrahippocampal infusions, ibotenate hippocampus + dentate lesions relevant aCSF...
This series of experiments investigated whether the NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) could induce impairments spatial learning across a dose range comparable to its impairment hippocampal long-term potentiation (LTP) in vivo. Estimations extracellular concentration D-AP5 hippocampus using microdialysis were also made compare these occur at concentrations similar those required impair LTP vitro slice. Rats chronically infused with into lateral ventricle (0-50...