A5057031090- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Axon Guidance and Neuronal Signaling
- Photoreceptor and optogenetics research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Visual perception and processing mechanisms
- Olfactory and Sensory Function Studies
- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Epilepsy research and treatment
- Neuroscience of respiration and sleep
- Advanced MRI Techniques and Applications
- Primate Behavior and Ecology
- Nicotinic Acetylcholine Receptors Study
- MicroRNA in disease regulation
- Neuroscience and Neural Engineering
Norwegian University of Science and Technology
2016-2025
Tohoku University
2021-2025
Kavli Institute for Systems Neuroscience
2011-2025
University of Ottawa
2025
University of Oxford
2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2000-2016
University of Science and Technology
2013
Center for Neurosciences
2000-2009
University Medical Center
2009
University Hospital and Clinics
2009
Grid cells in the medial entorhinal cortex (MEC) are part of an environment-independent spatial coordinate system. To determine how information about location, direction, and distance is integrated grid-cell network, we recorded from each principal cell layer MEC rats that explored two-dimensional environments. Whereas II was predominated by grid cells, colocalized with head-direction conjunctive x deeper layers. All types were modulated running speed. The conjunction positional,...
As the interface between hippocampus and neocortex, entorhinal cortex is likely to play a pivotal role in memory. To determine how information represented this area, we measured spatial modulation of neural activity layers medial projecting hippocampus. Close postrhinal-entorhinal border, neurons had stable discrete multipeaked place fields, predicting rat's location as accurately cells Precise positional was not observed more ventromedially or upstream postrhinal cortex, suggesting that...
Memory encoding occurs rapidly, but the consolidation of memory in neocortex has long been held to be a more gradual process. We now report, however, that systems can occur extremely quickly if an associative "schema" into which new information is incorporated previously created. In experiments using hippocampal-dependent paired-associate task for rats, flavor-place associations became persistent over time as putative neocortical schema gradually developed. New traces, trained only one...
Tauopathy in the brain of patients with Alzheimer's disease starts entorhinal cortex (EC) and spreads anatomically a defined pattern. To test whether pathology initiating EC through along synaptically connected circuits, we have generated transgenic mouse model that differentially expresses pathological human tau examined distribution at different timepoints. In relatively young mice (10-11 months old), was present some cell bodies, but it mostly observed axons within superficial layers...
Abstract Projections of the hippocampal formation to prefrontal cortex were visualized in rat by means anterograde tracer Phaseolus vulgaris ‐leucoagglutinin. These projections distribute only prelimbic and medial orbital cortices arise exclusively from restricted portions field CA1 Ammon's horn subiculum. The most dorsal portion does not contribute fibers this projection. In subiculum, its origin is proximal half, i.e., that directly borders CA1. Fibers subiculum have comparable...
To determine how spatial scale is represented in the pyramidal cell population of hippocampus, we recorded neural activity at multiple longitudinal levels this brain area while rats ran back and forth on an 18-meter-long linear track. CA3 cells had well-defined place fields all levels. The representation increased almost linearly from <1 meter dorsal pole to approximately 10 meters ventral pole. results suggest that place-cell map includes entire hippocampus environments are a...
In the adult brain, space and orientation are represented by an elaborate hippocampal-parahippocampal circuit consisting of head-direction cells, place grid cells. We report that a rudimentary map is already present when 2 1/2-week-old rat pups explore open environment outside nest for first time. Head-direction cells in pre- parasubiculum have adultlike properties from beginning. Place also but evolve more gradually. Grid show slowest development. The gradual refinement spatial...
Place cells in hippocampal area CA1 may receive positional information from the intrahippocampal associative network CA3 or directly entorhinal cortex. To determine whether direct connections support spatial firing and memory, we removed all input areas to CA1, thus isolating area. Pyramidal isolated developed sharp stable place fields. Rats with an showed normal acquisition of hippocampal-dependent recognition task. Spatial recall was impaired. These results suggest that hippocampus...
The topographic and laminar organization of entorhinal projections to the dentate gyrus, hippocampus, subicular complex was investigated in Macaca fascicularis monkey. Injections 3H-amino acids were placed at various positions within cortex distribution anterogradely labeled fibers terminals other fields hippocampal formation determined. retrograde tracers Fast blue, Diamidino yellow, wheat germ agglutinin-horseradish peroxidase (WGA-HRP) also into complex, retrogradely cells plotted using a...
The origins and terminations of entorhinal cortical projections in the rat were analyzed detail with retrograde anterograde tracing techniques. Retrograde fluorescent tracers injected different portions olfactory, medial frontal (infralimbic prelimbic areas), lateral (motor area), temporal (auditory), parietal (somatosensory), occipital (visual), cingulate, retrosplenial, insular, perirhinal cortices. Anterograde tracer injections placed various parts cortex to demonstrate laminar...