A5038973736- Gout, Hyperuricemia, Uric Acid
- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Cancer, Lipids, and Metabolism
- Veterinary medicine and infectious diseases
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Nutrition and Health in Aging
- Lung Cancer Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cardiovascular Issues in Pregnancy
- Pneumocystis jirovecii pneumonia detection and treatment
- Case Reports on Hematomas
- Inflammatory Biomarkers in Disease Prognosis
- Inflammasome and immune disorders
- Heart Failure Treatment and Management
Zhengzhou University
2023
Henan Provincial People's Hospital
2023
Henan University
2023
University College London
2022
Fujian Medical University
2022
Union Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2020
Third Affiliated Hospital of Guangzhou Medical University
2019-2020
Guangzhou Medical University
2019-2020
University of Glasgow
2016
Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed determine whether improves major outcomes in ischaemic heart disease.ALL-HEART was multicentre, prospective, randomised, open-label, blinded-endpoint trial done 18 regional centres England and Scotland, recruited from 424 primary care practices. Eligible were aged 60 years or older, disease...
Introduction Ischaemic heart disease (IHD) is one of the most common causes death in UK and treatment patients with IHD costs National Health System (NHS) billions pounds each year. Allopurinol a xanthine oxidase inhibitor used to prevent gout that also has several positive effects on cardiovascular system. The ALL-HEART study aims determine whether allopurinol improves outcomes IHD. Methods analysis multicentre, controlled, prospective, randomised, open-label blinded end point (PROBE) trial...
To characterize patients with urate measurements by urate-lowering therapy (ULT) use and to study the impact of allopurinol treatment on cardiovascular mortality outcomes.A cohort using a record-linkage database. The included 7135 aged ≥60 years between 2000 2002 followed up until 2007. A Cox regression model was used. association levels, dispensed hospitalization determined.Six thousand forty-two were not taking ULT 45.9% those (2774 6042) had concentrations ≤6 mg dl(-1) . Among 1035 users,...
Aims: The aim of the study was to explore long-term effect allopurinol on mortality and cardiovascular hospitalisations in heart failure (HF) patients. Methods: This is a population-based cohort using record-linkage database Tayside, Scotland. A total 4785 HF patients (4260 non-users, 267 incident users 258 prevalent users) were studied between 1993 2002. Results: Compared with low-dose group had significant increased risk all-cause mortality, recurrence (adjusted HR, 1.60, 95%CI 1.26–2.03;...
Objective: To investigate the association between total cholesterol (TC) and primary liver cancer in Chinese males. Methods: Since May 2006, all male workers, including employees retirees Kailuan Group were recruited dynamic cohort study. Information about demographics, medical history TC levels was collected at baseline interview, as well information on newly-diagnosed cases during follow-up period. A of 110 612 males by 31 December 2015. divided into four categories quartile (<4.27,...
Objectives Chronic obstructive pulmonary disease (COPD) is becoming a leading cause of morbidity and mortality in China. In the IMPACT trial, fluticasone furoate[FF]/umeclidinium[UMEC]/vilanterol[VI] single-inhaler triple therapy demonstrated lower rates moderate/severe exacerbations than dual with FF/VI or UMEC/VI patients symptomatic COPD history exacerbations. This analysis investigates China cohort its consistency overall ITT population.Methods 10,355 were randomized 2:2:1 to once-daily...
Objective: To investigate the association between anthropometry and colorectal cancer risk in Chinese males. Methods: Anthropometry incident cases were collected on a biennial basis starting May 2006 among males Kailuan Cohort (2006-2014). In addition, electronic database of hospitals affiliated to Community, Insurance System Community Tangshan also searched for supplementary information. Cox proportional hazards regression models linear used evaluate baseline Results: A total 106 786...
Objective: To investigate whether elevated levels of high sensitivity C-Reactive Protein (hsCRP) and neutrophil (NE) at baseline are associated with an increased risk colorectal cancer in Kailuan male cohort. Methods: Since May 2006, males from cohort were included this study. Information on demographics, medical history, anthropometry, hsCRP NE collectedat for all subjects. Multivariable Cox proportional hazards regression models used to calculate hazard ratios (HR) association between...
Background. Anoikis, a form of programed cell death, plays pivotal role in the invasion and metastasis various tumors, including lung squamous carcinoma (LUSC). This study aims to construct prognostic model for LUSC, leveraging anoikis-related genes (ARGs). Methods. A total 357 ARGs were extracted from GeneCards database Harmonizome portals. Subsequently, influencing LUSC patients’ prognosis identified using univariate Cox regression analysis. Unsupervised clustering analysis was carried out...
Abstract Background In the Phase III InforMing PAthway of COPD Treatment (IMPACT) trial, fluticasone furoate [FF]/umeclidinium [UMEC]/vilanterol [VI] single-inhaler triple therapy resulted in lower rates moderate/severe exacerbations than dual with FF/VI or UMEC/VI patients symptomatic chronic obstructive pulmonary disease (COPD) and a history exacerbations. Here we present result subpopulation enrolled China. Methods The IMPACT trial was 52-week, randomized, double-blind, parallel-group,...