A5035800669- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Hormonal Regulation and Hypertension
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Cardiovascular Issues in Pregnancy
- Atrial Fibrillation Management and Outcomes
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- COVID-19 Clinical Research Studies
- Blood Pressure and Hypertension Studies
- Cardiac Fibrosis and Remodeling
- Advanced MRI Techniques and Applications
- Diabetes Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Ion channel regulation and function
- Long-Term Effects of COVID-19
- Cardiovascular Disease and Adiposity
- Cardiovascular Effects of Exercise
- Adrenal and Paraganglionic Tumors
- Signaling Pathways in Disease
National Health Service
2023-2024
Hairmyres Hospital
2014-2024
Golden Jubilee National Hospital
2023
NHS Lanarkshire
2020
Pfizer (United Kingdom)
2014
Monklands Hospital
2011-2013
Western Infirmary
2005-2013
University of Glasgow
2008-2013
National Institute for Health Research
2013
Leicester Royal Infirmary
2013
BACKGROUND: Community acquired pneumonia remains an important cause of hospital admission and carries appreciable mortality. Criteria for the assessment severity during have been developed by British Thoracic Society (BTS). A study was performed to determine sensitivity specificity a rule based on modification BTS prognostic rules applied admission, compare as assessed medical staff with modified rule, microbiological community in Christchurch. METHODS: 12 month all adults admitted...
Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed determine whether improves major outcomes in ischaemic heart disease.ALL-HEART was multicentre, prospective, randomised, open-label, blinded-endpoint trial done 18 regional centres England and Scotland, recruited from 424 primary care practices. Eligible were aged 60 years or older, disease...
Abstract Background and Aims To examine the decongestive effect of sodium-glucose cotransporter 2 inhibitor dapagliflozin compared to thiazide-like diuretic metolazone in patients hospitalized for heart failure resistant treatment with intravenous furosemide. Methods results A multi-centre, open-label, randomized, active-comparator trial. Patients were randomized 10 mg once daily or 5–10 a 3-day period, follow-up primary secondary endpoints until day 5 (96 h). The endpoint was effect,...
We aimed to assess the impact of eplerenone on cardiovascular (CV) outcomes in STEMI without known heart failure, when initiated within 24 h symptom onset. In this randomized, placebo-controlled, double-blind trial, we assigned 1012 patients with acute and a history failure receive either (25–50 mg once daily) or placebo addition standard therapy. The primary endpoint was composite CV mortality, re-hospitalization, or, extended initial hospital stay, due diagnosis HF, sustained ventricular...
<h3>Importance</h3> Microvascular obstruction commonly affects patients with acute ST-segment elevation myocardial infarction (STEMI) and is associated adverse outcomes. <h3>Objective</h3> To determine whether a therapeutic strategy involving low-dose intracoronary fibrinolytic therapy alteplase infused early after coronary reperfusion will reduce microvascular obstruction. <h3>Design, Setting, Participants</h3> Between March 17, 2016, December 21, 2017, 440 presenting at 11 hospitals in the...
Abstract The pathophysiology and trajectory of post-Coronavirus Disease 2019 (COVID-19) syndrome is uncertain. To clarify multisystem involvement, we undertook a prospective cohort study including patients who had been hospitalized with COVID-19 (ClinicalTrials.gov ID NCT04403607 ). Serial blood biomarkers, digital electrocardiography patient-reported outcome measures were obtained in-hospital at 28–60 days post-discharge when imaging using chest computed tomography pulmonary coronary...
The epidemiology of peripartum cardiomyopathy (PPCM) in Europe is poorly understood and data on long-term outcomes are lacking. A retrospective, observational, population-level study validated cases PPCM Scotland from 1998 to 2017 was conducted.Women hospitalized with presumed de novo left ventricular systolic dysfunction around the time pregnancy no clear alternative cause were included. Each case matched 10 controls. Incidence risk factors identified. Morbidity mortality examined mothers...
Background— Galectin-3 is a biomarker associated with inflammation and fibrosis that predicts adverse outcome relates to biomarkers of extracellular matrix turnover in patients heart failure, particularly when left ventricular (LV) systolic function preserved. Whether galectin-3 related LV remodeling after acute myocardial infarction unknown. Methods Results— Circulating various were measured 100 (age, 58.9±12.0 years; 77% men) admitted dysfunction, at baseline (mean 46 hours) 24 weeks,...
Primary aldosteronism (PA) is common and associates with excess cardiovascular morbidity independent of blood pressure. Exposure to aldosterone sodium leads cardiac fibrosis hypertrophy in humans animals possibly mediated by inflammation oxidative stress. We aimed clarify the effects on myocardial structure composition human subjects PA essential hypertension using contrast-enhanced magnetic resonance imaging as well explore mechanistic basis for any observed differences.Twenty-seven...
Microvascular obstruction (MO) is associated with large acute myocardial infarction and lower left ventricular (LV) ejection fraction predicts greater remodeling, but whether this effect abolished by contemporary antiremodeling therapies subject to debate. We examined the influence of several infarct characteristics, including MO, on LV remodeling in an optimally treated post-acute cohort, using contrast-enhanced cardiac magnetic resonance.One hundred patients (mean age, 58.9+/-12 years,...
Background: Microvascular angina is associated with dysregulation of the endothelin system and impairments in myocardial blood flow, exercise capacity, health-related quality life. The G allele noncoding single nucleotide polymorphism RS9349379 enhances expression endothelin-1 gene ( EDN1 ) human vascular cells, potentially increasing circulating concentrations Endothelin-1 (ET-1). Whether zibotentan, an oral ET-A receptor selective antagonist, efficacious safe for treatment microvascular...