A5008825793- Autoimmune and Inflammatory Disorders Research
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Rheumatoid Arthritis Research and Therapies
- Nail Diseases and Treatments
- Sports injuries and prevention
- Cardiomyopathy and Myosin Studies
- Foot and Ankle Surgery
- Mechanical Circulatory Support Devices
- Cardiovascular Health and Disease Prevention
NHS Greater Glasgow and Clyde
2022-2025
Women's and Children's Hospital
1999
Background: Microvascular angina is associated with dysregulation of the endothelin system and impairments in myocardial blood flow, exercise capacity, health-related quality life. The G allele noncoding single nucleotide polymorphism RS9349379 enhances expression endothelin-1 gene ( EDN1 ) human vascular cells, potentially increasing circulating concentrations Endothelin-1 (ET-1). Whether zibotentan, an oral ET-A receptor selective antagonist, efficacious safe for treatment microvascular...
Background People with rheumatoid arthritis experience foot and lower limb pain due to active synovitis, resulting in impaired function. Earlier intervention may help prevention of functional decline. The aims this research were develop evaluate a new gait rehabilitation for people early arthritis, its feasibility, test whether or not plus usual care is more clinically cost-effective than alone. Design methods We undertook single-arm, repeated-measures, pre- post-intervention, mixed-methods...
Foot impairments in early rheumatoid arthritis are common and lead to progressive deterioration of lower limb function. A gait rehabilitation programme underpinned by psychological techniques improve adherence, may preserve This study evaluated the feasibility a novel intervention (GREAT Strides) future trial. was mixed methods with embedded qualitative components. People (< 2 years) (RA) foot pain were eligible. Intervention acceptability using questionnaire. Adherence Exercise Rating Scale...
Abstract Microvascular angina, linked to endothelin system dysregulation, was the focus of this double-blind, placebo-controlled, randomized, sequential crossover trial (NCT04097314). The compared zibotentan, an oral A receptor selective antagonist, with placebo in 118 patients microvascular angina. Over 12 weeks, participants received either 10 mg daily zibotentan or placebo, primary outcome treadmill exercise duration. study found no significant difference duration (-4.26 seconds; 95% CI:...
Abstract Background Foot impairments in early rheumatoid arthritis are common and lead to progressive deterioration of lower limb function. A gait rehabilitation programme underpinned by psychological techniques improve adherence, may preserve This study evaluated the feasibility a novel intervention (GREAT Strides) future trial. Methods was mixed methods with embedded qualitative components. People (<2 years) (RA) foot pain were eligible. Intervention acceptability using questionnaire....