A5023675541- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Cardiovascular Effects of Exercise
- Cardiovascular and exercise physiology
- Forensic Toxicology and Drug Analysis
- Pharmaceutical Economics and Policy
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Frailty in Older Adults
- Venous Thromboembolism Diagnosis and Management
- Ultrasound in Clinical Applications
- Cardiac Health and Mental Health
- Lipoproteins and Cardiovascular Health
- Hemodynamic Monitoring and Therapy
United Lincolnshire Hospitals NHS Trust
2024
Northumbria Healthcare NHS Foundation Trust
2024
Freeman Hospital
2024
Newcastle University
2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2024
University of Liverpool
2011-2024
Blackpool Teaching Hospitals NHS Foundation Trust
2017-2024
Blackpool Victoria Hospital
2011-2024
Royal Free London NHS Foundation Trust
2023
Aalborg University
2021-2022
BackgroundWhether a conservative strategy of medical therapy alone or plus invasive treatment is more beneficial in older adults with non–ST-segment elevation myocardial infarction (NSTEMI) remains unclear.MethodsWe conducted prospective, multicenter, randomized trial involving patients 75 years age NSTEMI at 48 sites the United Kingdom. The were assigned 1:1 ratio to best available an coronary angiography and revascularization therapy. Patients who frail had high burden coexisting...
Aims To define the N-terminal pro-brain natriuretic peptide (NTpBNP) normal range, assessing its cardiovascular screening characteristics in general population and higher risk subjects.
Microvascular angina is caused by cardiac small vessel disease, and dysregulation of the endothelin system implicated. The minor G allele non-coding single nucleotide polymorphism (SNP) rs9349379 enhances expression 1 gene in human vascular cells, increasing circulating concentrations ET-1. prevalence this higher patients with ischemic heart disease. Zibotentan a potent, selective inhibitor ET
Background: Microvascular angina is associated with dysregulation of the endothelin system and impairments in myocardial blood flow, exercise capacity, health-related quality life. The G allele noncoding single nucleotide polymorphism RS9349379 enhances expression endothelin-1 gene ( EDN1 ) human vascular cells, potentially increasing circulating concentrations Endothelin-1 (ET-1). Whether zibotentan, an oral ET-A receptor selective antagonist, efficacious safe for treatment microvascular...
Aims To assess the screening characteristics and cost-effectiveness of for left ventricular systolic dysfunction (LVSD) in community subjects.
<h3>OBJECTIVE</h3> To characterise echocardiographic wall motion score index (WMSI) as a surrogate measure of left ventricular ejection fraction (EF) following acute myocardial infarction (AMI) and to compare its prognostic value with that EF measured by radionuclide ventriculography (RNV). <h3>DESIGN</h3> A prospective study baseline WMSI RNV in consecutive patients thrombolysed for AMI, both performed on the same day before discharge, their relative values predicting cardiac events....
Aims: Heart failure is placing an increasing burden on society. This has led to calls for echocardiographicbased programmes screen left ventricular systolic dysfunction and other cardiac abnormalities. Echocardiography using new fully portable echocardiography devices would allow community-based cost-effective screening once validated. study was undertaken evaluate this further in both high low-risk subjects.
As life expectancy increases, the population of older individuals with coronary artery disease and frailty is growing. We aimed to assess impact patient-reported on treatment prognosis elderly early survivors non-ST-elevation acute syndrome (NSTE-ACS).
Background: N-terminal pro-B type natriuretic peptide (NTpBNP) is a potential marker of cardiac failure. Methods: The Roche Elecsys TM 1010 and 2010 assays for NTpBNP were evaluated precision, sample stability, correlation between types with other peptides. Samples from 290 individuals aged 45-89 years no cardiovascular risk factors, renal failure, electrocardiogram changes, evidence structural abnormalities, or wall motion abnormalities on echocardiography an ejection fraction >50% used...
<h3>Abstract</h3> We examined copper accumulation in the hemolymph, gills and hepatopancreas, hemolymph osmolality, Na<sup>+</sup> Cl<sup>-</sup> concentrations, together with gill Na<sup>+</sup>/K<sup>+</sup>-ATPase carbonic anhydrase activities, after dietary delivery (0, 100 or 500 µg Cu/g) for 12 days a fiddler crab, <i>Minuca rapax</i>. In contaminated crabs, concentration decreased but increased gills. Hemolymph osmolality activity while [Na<sup>+</sup>] [Cl<sup>-</sup>] decreased....
To ascertain the level of psychological distress, using validated psychology tools, among British National healthcare workers (HCW) during first wave Covid-19 crisis.A multi-centre, anonymized, all-comer staff survey across 3 hospitals in Lancashire, England (April to June 2020), consisting Patient Health Questionnaire (PHQ-9), Perceived Stress Scale-10 (PSS-10), Generalized Anxiety Disorder-7 (GAD-7), and Impact Events Scale (IES-6).Among 1113 HCW, median (IQR) PHQ-9, GAD-7, PSS-10, IES-6...
Background In the GLOBAL LEADERS trial, ticagrelor monotherapy beyond 1 month compared with standard antiplatelet regimens after coronary stent implantation did not improve outcomes at intention‐to‐treat analysis. Considerable differences in treatment adherence between experimental and control groups may have affected results. this reanalysis of we strategies a per‐protocol analysis patients who deviate from study protocol. Methods Results Baseline postrandomization information were used to...
A 45-year-old previously healthy man with minimal coronary artery disease on imaging presented an acute MI after sustaining a wasp sting following previous non-eventful exposures throughout his life. This is the first case of Kounis syndrome optical coherence tomography and proven IgE venom hypersensitivity. The Hymenoptera composed allergenic proteins vasoactive amines which are responsible for toxicity. patient also has history atopy giving predisposition developing IgE-mediated allergic...
Heart failure is placing an increasing burden on society. This has led to calls for echocardiographic-based programmes screen left ventricular systolic dysfunction and other cardiac abnormalities. Echocardiography using new fully portable echocardiography devices would allow community-based cost-effective screening once validated. study was undertaken evaluate this further in both high low-risk subjects.562 consecutive subjects attending a heart programme, some at high-risk of abnormalities,...
Acute heart failure (AHF) hospitalisation is associated with 10% mortality. Outpatient based management (OPM) of AHF appeared effective in observational studies. We conducted a pilot randomised controlled trial (RCT) comparing OPM standard inpatient care (IPM).We patients AHF, considered to need IV diuretic treatment for ≥2 days, IPM or OPM. recorded all-cause mortality, and the number days alive out-of-hospital (DAOH). Quality life, mental well-being Hope scores were assessed. Mean NHS cost...
To investigate the impact of different anti-platelet strategies on outcomes after percutaneous coronary intervention (PCI) in patients with established cardiovascular disease (CVD).GLOBAL LEADERS was a randomized, superiority, all-comers trial comparing one-month dual therapy (DAPT) ticagrelor and aspirin followed by 23-month monotherapy (experimental treatment) standard 12-month DAPT (reference treated biolimus A9-eluting stent. Established CVD defined as ≥1 prior myocardial infarction,...
In percutaneous coronary interventions, use of the radial artery may be limited by vascular anatomy or complications, such as spasm, dissection perforation. The balloon-assisted tracking (BAT) technique is a novel and innovative method to successfully perform transradial procedures in patients with difficult anatomy, severe tortuosity spasm. addition, BAT can serve bail-out when complications perforation occur.We analysed data all intervention whom was undertaken daily practice report acute...
This is the case of a 53-year-old man with known coronary artery disease who underwent two exercise treadmill tests (ETT). The first test, which yielded an abnormal result, was undertaken shortly after he had drunk cans Red Bull, popular energy drink (ED). A second ETT 1 week later by same team without EDs on board and test result normal. suggests that drinking prior to could lead false positive should be discouraged testing.
This registry assessed the impact of conservative and invasive strategies on major adverse clinical events (MACE) in elderly patients with non-ST-elevation myocardial infarction (NSTEMI). Patients aged ≥75 years NSTEMI were prospectively registered from European centers followed up for one year. Outcomes compared between groups overall population a propensity score-matched (PSM) cohort. MACE included cardiovascular death, acute coronary syndrome, stroke. The study 1190 (median age 80 years,...
A 58 year old man was admitted to his local emergency department in electromechanical dissociation (EMD), having collapsed at home. Cardiac output soon returned following an adrenaline bolus. His pupils were normal size and reacting, there no neck stiffness, he moved right leg spontaneously. diagnosis of acute …
<b>Objective:</b> To assess the accuracy of echocardiography with Simpson's apical biplane method in screening for left ventricular systolic dysfunction (LVSD) patients six months after acute myocardial infarction (AMI) as compared radionuclide ventriculography by assessing proportion clinically significant errors that occur echocardiography. <b>Design:</b> Comparison results and ejection fraction among AMI. <b>Setting:</b> District general hospital. <b>Patients:</b> 86 thrombolysed AMI at...